YRC Public Data Repository - Protein Structure Prediction

Protein:	YEHZ_ECOLI
Organism:	Escherichia coli
Length:	305 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEHZ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|167039848, gi... - gi\|167039848\|ref\|YP_001662833.1\| substrate-binding region of ABC-type glycine betaine transport syst... gi\|242256263, gi... - gi\|242256263\|ref\|ZP_04801157.1\| Substrate-binding region of ABC-type glycine betaine transport syste...	264.0	[0..1]	[304..1]
gi\|42737300, gi\|... - gi\|42781378\|ref\|NP_978625.1\| glycine betaine/L-proline ABC transporter, permease protein, putative [...	257.0	[0..2]	[305..210]
gi\|56418850, gi\|... - gi\|56418850\|ref\|YP_146168.1\| hypothetical protein GK0315 [Geobacillus kaustophilus HTA426], gi\|56378...	256.0	[0..1]	[304..1]
gi\|83573435, gi\|... - gi\|83590521\|ref\|YP_430530.1\| substrate-binding region of ABC-type glycine betaine transport system [...	256.0	[0..2]	[305..10]
gi\|89205566, gi\|... - gi\|89205566\|ref\|ZP_01184135.1\| Binding-protein-dependent transport systems inner membrane component:...	256.0	[0..2]	[305..210]
gi\|47557274, gi\|... - gi\|47565638\|ref\|ZP_00236678.1\| MW0685 [Bacillus cereus G9241], gi\|47557274\|gb\|EAL15602.1\| MW0685 [Ba...	254.0	[0..2]	[305..210]
gi\|195993503, gi... - gi\|196033823\|ref\|ZP_03101234.1\| glycine betaine/L-proline ABC transporter, permease and substrate-bi... gi\|229121836, gi... - gi\|229121836\|ref\|ZP_04251056.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|228692038, gi... - gi\|229091272\|ref\|ZP_04222490.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|49477588, gi\|... - gi\|49477588\|ref\|YP_036392.1\| glycine betaine/choline ABC transporter, ATP-binding protein [Bacillus ... gi\|228813776, gi... - gi\|228945902\|ref\|ZP_04108245.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|228927351, gi... - gi\|228927351\|ref\|ZP_04090408.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/...	254.0	[0..2]	[305..210]
gi\|126168719, gi... - gi\|84319452\|ref\|ZP_00967849.1\| COG1732: Periplasmic glycine betaine/choline-binding (lipo)protein of... gi\|107103405 - gi\|107103405\|ref\|ZP_01367323.1\| hypothetical protein PaerPA_01004475 [Pseudomonas aeruginosa PACS2]	254.0	[0..1]	[304..1]
gi\|228632996, gi... - gi\|229150503\|ref\|ZP_04278719.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|218160565, gi... - gi\|218232608\|ref\|YP_002366980.1\| glycine betaine/L-proline ABC transporter, permease and substrate-b... gi\|229044025, gi... - gi\|229044025\|ref\|ZP_04191714.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|228958548, gi... - gi\|228958548\|ref\|ZP_04120268.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|228807087, gi... - gi\|228952621\|ref\|ZP_04114697.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|228638595, gi... - gi\|229144873\|ref\|ZP_04273270.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|229127677, gi... - gi\|229127677\|ref\|ZP_04256666.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|30020367, gi\|... - gi\|30020367\|ref\|NP_831998.1\| glycine betaine transport system permease protein / glycine betaine-bin... gi\|229109720, gi... - gi\|229109720\|ref\|ZP_04239306.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/... gi\|229079450, gi... - gi\|229079450\|ref\|ZP_04211990.1\| Glycine betaine/L-proline ABC transporter, permease/glycine betaine/...	253.0	[0..2]	[305..210]
gi\|49085406 - gi\|49085406\|gb\|AAT51275.1\| PA3889 [synthetic construct]	253.0	[0..1]	[304..1]

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Predicted Domain #1

Region A:
Residues: [1-305]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLLKLWAGS LVMLAAVSLP LQAASPVKVG SKIDTEGALL GNIILQVLES HGVPTVNKVQ  60
   61 LGTTPVVRGA ITSGELDIYP EYTGNGAFFF KDENDAAWKN AQQGYEKVKK LDSEHNKLIW 120
  121 LTPAPANNTW TIAVRQDVAE KNKLTSLADL SRYLQEGGTF KLAASAEFIE RADALPAFEK 180
  181 AYGFKLGQDQ LLSLAGGDTA VTIKAAAQQT SGVNAAMAYG TDGPVAALGL QTLSDPQGVQ 240
  241 PIYAPAPVVR ESVLREYPQM AQWLQPVFAS LDAKTLQQLN ASIAVEGLDA KKVAADYLKQ 300
  301 KGWTK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.30103
Match:	1sw2A
Description:	Crystal structure of ProX from Archeoglobus fulgidus in complex with glycine betaine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
amine transmembrane transporter activity	2.8505643526173	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.80786841862036	bayes_pls_golite062009
transporter activity	2.37767937786605	bayes_pls_golite062009
ion transmembrane transporter activity	2.19564149972908	bayes_pls_golite062009
transmembrane transporter activity	2.14027396604232	bayes_pls_golite062009
active transmembrane transporter activity	1.98824826924235	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.92247368464925	bayes_pls_golite062009
primary active transmembrane transporter activity	1.91778402126342	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.91458600392598	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.91458600392598	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.91424996753266	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.88446253507704	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.68289701302071	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.65555448677681	bayes_pls_golite062009
ATPase activity, coupled	1.59154512845516	bayes_pls_golite062009
substrate-specific transporter activity	1.51716707550629	bayes_pls_golite062009
ATPase activity	1.44327228942016	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.36989838880058	bayes_pls_golite062009
pyrophosphatase activity	1.33033652028872	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.31993399326424	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.31926578892427	bayes_pls_golite062009
amine-transporting ATPase activity	1.26059419028501	bayes_pls_golite062009
amino acid-transporting ATPase activity	1.25084210844339	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.06410714245	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	1.06102061998642	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	0.919969356414241	bayes_pls_golite062009
anion transmembrane transporter activity	0.89537702998218	bayes_pls_golite062009
binding	0.841985743602294	bayes_pls_golite062009
polyamine transmembrane transporter activity	0.82443378583023	bayes_pls_golite062009
cation transmembrane transporter activity	0.799357659531325	bayes_pls_golite062009
polyamine-transporting ATPase activity	0.605434747769831	bayes_pls_golite062009
hydrolase activity	0.52200036125335	bayes_pls_golite062009
amine binding	0.48583609326514	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.301206065600289	bayes_pls_golite062009
catalytic activity	0.278324746769832	bayes_pls_golite062009
quaternary-ammonium-compound-transporting ATPase activity	0.276782479687659	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.202264690255979	bayes_pls_golite062009
amino acid binding	0.0252217029836901	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: