YRC Public Data Repository - Protein Structure Prediction

Protein:	TTUC_ECOLI
Organism:	Escherichia coli
Length:	361 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TTUC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91691280, gi\|... - gi\|91778620\|ref\|YP_553828.1\| tartrate dehydrogenase [Burkholderia xenovorans LB400], gi\|91691280\|gb\|...	458.0	[0..1]	[360..1]
gi\|74311888, gi\|... - gi\|74311888\|ref\|YP_310307.1\| putative tartrate dehydrogenase [Shigella sonnei Ss046], gi\|73855365\|gb...	452.0	[0..1]	[361..1]
gi\|193066367, gi... - gi\|75255573\|ref\|ZP_00727360.1\| COG0473: Isocitrate/isopropylmalate dehydrogenase [Escherichia coli E... gi\|218554372, gi... - gi\|218554372\|ref\|YP_002387285.1\| putative tartrate dehydrogenase [Escherichia coli IAI1], gi\|2183611...	452.0	[0..1]	[361..1]
gi\|15802213, gi\|... - gi\|15802213\|ref\|NP_288236.1\| putative tartrate dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|1... gi\|217328808, gi... - gi\|217328808\|ref\|ZP_03444889.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. ... gi\|13361976, gi\|... - gi\|15831763\|ref\|NP_310536.1\| putative tartrate dehydrogenase [Escherichia coli O157:H7], gi\|13361976... gi\|209160402, gi... - gi\|209399002\|ref\|YP_002270877.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str.... gi\|208818309, gi... - gi\|208818309\|ref\|ZP_03258629.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. ... gi\|13361976, gi\|... - gi\|15831763\|ref\|NP_310536.1\| putative tartrate dehydrogenase [Escherichia coli O157:H7 str. Sakai], ... gi\|208816862, gi... - gi\|208816862\|ref\|ZP_03257982.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. ... gi\|189000252, gi... - gi\|189000252\|gb\|EDU69238.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC40... gi\|254592822, gi... - gi\|254793422\|ref\|YP_003078259.1\| predicted dehydrogenase [Escherichia coli O157:H7 str. TW14359], gi... gi\|168774885, gi... - gi\|187769379\|gb\|EDU33223.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC41... gi\|189360388, gi... - gi\|189360388\|gb\|EDU78807.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC44... gi\|189365716, gi... - gi\|189365716\|gb\|EDU84132.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC45... gi\|208725282, gi... - gi\|208810766\|ref\|ZP_03252642.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. ... gi\|195937488 - gi\|195937488\|ref\|ZP_03082870.1\| putative tartrate dehydrogenase [Escherichia coli O157:H7 str. EC402... gi\|189376709, gi... - gi\|189376709\|gb\|EDU95125.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC50... gi\|189372077, gi... - gi\|189372077\|gb\|EDU90493.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC86... gi\|189355046, gi... - gi\|189355046\|gb\|EDU73465.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC44... gi\|188016263, gi... - gi\|188016263\|gb\|EDU54385.1\| tartrate dehydrogenase/decarboxylase [Escherichia coli O157:H7 str. EC41... gi\|25283815, gi\|... - pir\|\|A85791 probable tartrate dehydrogenase yeaU [imported] - Escherichia coli (strain O157:H7, subs...	451.0	[0..1]	[361..1]
gi\|75177273, gi\|... - gi\|75177273\|ref\|ZP_00697362.1\| COG0473: Isocitrate/isopropylmalate dehydrogenase [Shigella boydii BS...	450.0	[0..1]	[361..1]
gi\|81241112, gi\|... - gi\|82776964\|ref\|YP_403313.1\| putative tartrate dehydrogenase [Shigella dysenteriae Sd197], gi\|812411...	450.0	[0..1]	[361..1]
gi\|75208732, gi\|... - gi\|75208732\|ref\|ZP_00709024.1\| COG0473: Isocitrate/isopropylmalate dehydrogenase [Escherichia coli B...	449.0	[0..1]	[361..1]
gi\|254288647, gi... - gi\|254288647\|ref\|YP_003054395.1\| predicted dehydrogenase [Escherichia coli BL21(DE3)], gi\|253977954\|... gi\|242377521, gi... - gi\|251785248\|ref\|YP_002999552.1\| hypothetical protein B21_01758 [Escherichia coli BL21], gi\|24237752... gi\|254161859, gi... - gi\|254161859\|ref\|YP_003044967.1\| predicted dehydrogenase [Escherichia coli B str. REL606], gi\|253973... gi\|194439632, gi... - gi\|83584985\|ref\|ZP_00923640.1\| COG0473: Isocitrate/isopropylmalate dehydrogenase [Escherichia coli 1...	449.0	[0..1]	[361..1]
gi\|17432087 - gi\|17432087\|emb\|CAD18763.1\| probable tartrate dehydrogenase oxidoreductase protein [Ralstonia solana... gi\|17549831 - gi\|17549831\|ref\|NP_523171.1\| tartrate dehydrogenase oxidoreductase protein [Ralstonia solanacearum G...	447.0	[0..3]	[360..4]
gi\|82543797, gi\|... - gi\|82543797\|ref\|YP_407744.1\| putative tartrate dehydrogenase [Shigella boydii Sb227], gi\|81245208\|gb...	447.0	[0..1]	[361..1]

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Predicted Domain #1

Region A:
Residues: [1-361]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKTMRIAAI PGDGIGKEVL PEGIRVLQAA AERWGFALSF EQMEWASCEY YSHHGKMMPD  60
   61 DWHEQLSRFD AIYFGAVGWP DTVPDHISLW GSLLKFRREF DQYVNLRPVR LFPGVPCPLA 120
  121 GKQPGDIDFY VVRENTEGEY SSLGGRVNEG TEHEVVIQES VFTRRGVDRI LRYAFELAQS 180
  181 RPRKTLTSAT KSNGLAISMP YWDERVEAMA ENYPEIRWDK QHIDILCARF VMQPERFDVV 240
  241 VASNLFGDIL SDLGPACTGT IGIAPSANLN PERTFPSLFE PVHGSAPDIY GKNIANPIAT 300
  301 IWAGAMMLDF LGNGDERFQQ AHNGILAAIE EVIAHGPKTP DMKGNATTPQ VADAICKIIL 360
  361 R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	115.0
Match:	1cnzA
Description:	3-isopropylmalate dehydrogenase, IPMDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
isocitrate dehydrogenase (NAD+) activity	5.9567768649084	bayes_pls_golite062009
isocitrate dehydrogenase activity	5.76817846591752	bayes_pls_golite062009
3-isopropylmalate dehydrogenase activity	4.43187390953534	bayes_pls_golite062009
isocitrate dehydrogenase (NADP+) activity	3.47645456015586	bayes_pls_golite062009
malate dehydrogenase activity	3.17013707624362	bayes_pls_golite062009
oxidoreductase activity	2.74237430402883	bayes_pls_golite062009
catalytic activity	2.71251959637136	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.46799258909805	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.38235863668553	bayes_pls_golite062009
binding	1.19820115767498	bayes_pls_golite062009
malic enzyme activity	0.483776792839856	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.466038297142601	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: