YRC Public Data Repository - Protein Structure Prediction

Protein:	THIP_ECOLI
Organism:	Escherichia coli
Length:	536 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THIP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|187428994, gi... - gi\|75175625\|ref\|ZP_00695833.1\| COG1178: ABC-type Fe3+ transport system, permease component [Shigella... gi\|82542671, gi\|... - gi\|82542671\|ref\|YP_406618.1\| thiamine transporter membrane protein [Shigella boydii Sb227], gi\|81244...	239.0	[0..1]	[536..1]
gi\|110613679, gi... - gi\|110804131\|ref\|YP_687651.1\| thiamine transporter membrane protein [Shigella flexneri 5 str. 8401],...	239.0	[0..1]	[536..1]
gi\|75234306, gi\|... - gi\|75234306\|ref\|ZP_00718684.1\| COG1178: ABC-type Fe3+ transport system, permease component [Escheric...	238.0	[0..1]	[536..1]
gi\|75194286, gi\|... - gi\|75194286\|ref\|ZP_00704356.1\| COG1178: ABC-type Fe3+ transport system, permease component [Escheric...	238.0	[0..1]	[536..1]
gi\|218359418, gi... - gi\|218552650\|ref\|YP_002385563.1\| thiamine transporter membrane protein [Escherichia coli IAI1], gi\|2... gi\|194429380, gi... - gi\|75209411\|ref\|ZP_00709643.1\| COG1178: ABC-type Fe3+ transport system, permease component [Escheric... gi\|30039874, gi\|... - gi\|30061632\|ref\|NP_835803.1\| thiamine transporter membrane protein [Shigella flexneri 2a str. 2457T]... gi\|24111510, gi\|... - gi\|24111510\|ref\|NP_706020.1\| thiamine transporter membrane protein [Shigella flexneri 2a str. 301], ... gi\|209917258, gi... - gi\|209917258\|ref\|YP_002291342.1\| thiamine transporter membrane protein [Escherichia coli SE11], gi\|2...	238.0	[0..1]	[536..1]
gi\|188487634, gi... - gi\|75511709\|ref\|ZP_00734347.1\| COG1178: ABC-type Fe3+ transport system, permease component [Escheric...	238.0	[0..1]	[536..1]
gi\|254160190, gi... - gi\|254160190\|ref\|YP_003043298.1\| thiamin ABC transporter membrane protein [Escherichia coli B str. R... gi\|238899469, gi... - gi\|238899469\|ref\|YP_002925265.1\| fused thiamin transporter subunits of ABC superfamily: membrane com... gi\|194439389, gi... - gi\|83585209\|ref\|ZP_00923859.1\| COG1178: ABC-type Fe3+ transport system, permease component [Escheric... gi\|254286993, gi... - gi\|254286993\|ref\|YP_003052741.1\| thiamin ABC transporter membrane protein [Escherichia coli BL21(DE3... gi\|242375904, gi... - gi\|251783631\|ref\|YP_002997935.1\| hypothetical protein B21_00068 [Escherichia coli BL21], gi\|24237590...	237.0	[0..1]	[536..1]
gi\|157079520, gi... - gi\|75189169\|ref\|ZP_00702436.1\| COG1178: ABC-type Fe3+ transport system, permease component [Escheric...	237.0	[0..1]	[536..1]
gi\|73854161, gi\|... - gi\|74310684\|ref\|YP_309103.1\| thiamine transporter membrane protein [Shigella sonnei Ss046], gi\|73854...	237.0	[0..1]	[536..1]
gi\|208805801, gi... - gi\|208805801\|ref\|ZP_03248138.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [E... gi\|208733523, gi... - gi\|208812246\|ref\|ZP_03253575.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [E... gi\|208821811, gi... - gi\|208821811\|ref\|ZP_03262131.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [E... gi\|209159694, gi... - gi\|209398294\|ref\|YP_002268675.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [... gi\|209746768, gi... - pir\|\|G90637 probable transport system permease protein ECs0071 [imported] - Escherichia coli (strain... gi\|15829325, gi\|... - gi\|15829325\|ref\|NP_308098.1\| thiamine transporter membrane protein [Escherichia coli O157:H7 str. Sa... gi\|189000380, gi... - gi\|189000380\|gb\|EDU69366.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|168789592, gi... - gi\|189370835\|gb\|EDU89251.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|15799751, gi\|... - gi\|15799751\|ref\|NP_285763.1\| thiamine transporter membrane protein [Escherichia coli O157:H7 EDL933]... gi\|189376369, gi... - gi\|189376369\|gb\|EDU94785.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|15829325, gi\|... - gi\|15829325\|ref\|NP_308098.1\| thiamin ABC transporter membrane component [Escherichia coli O157:H7], ... gi\|195939283 - gi\|195939283\|ref\|ZP_03084665.1\| thiamine transporter membrane protein [Escherichia coli O157:H7 str.... gi\|168755673, gi... - gi\|189357095\|gb\|EDU75514.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|189365888, gi... - gi\|189365888\|gb\|EDU84304.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|189359904, gi... - gi\|189359904\|gb\|EDU78323.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|187767756, gi... - gi\|187767756\|gb\|EDU31600.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|168751425, gi... - gi\|188014539\|gb\|EDU52661.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [Esche... gi\|254791205, gi... - gi\|254791205\|ref\|YP_003076042.1\| membrane component of thiamin ABC transporter [Escherichia coli O15... gi\|217326577, gi... - gi\|217326577\|ref\|ZP_03442661.1\| thiamine/thiamine pyrophosphate ABC transporter, permease protein [E...	236.0	[0..1]	[536..1]

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Predicted Domain #1

Region A:
Residues: [1-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRRQPLIP GWLIPGVSAT TLVVAVALAA FLALWWNAPQ DDWVAVWQDS YLWHVVRFSF  60
   61 WQAFLSALLS VIPAIFLARA LYRRRFPGRL ALLRLCAMTL ILPVLVAVFG ILSVYGRQGW 120
  121 LATLCQSLGL EWTFSPYGLQ GILLAHVFFN LPMASRLLLQ ALENIPGEQR QLAAQLGMRS 180
  181 WHFFRFVEWP WLRRQIPPVA ALIFMLCFAS FATVLSLGGG PQATTIELAI YQALSYDYDP 240
  241 ARAAMLALLQ MVCCLGLVLL SQRLSKAIA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	7.61
Match:	2onkC
Description:	No description for 2onkC was found.

Predicted functions:

Term	Confidence	Notes
sulfate transmembrane transporter activity	10.5410256198788	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	8.29749837106188	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	7.61517440483825	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	7.61475955752567	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	7.61475955752567	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	7.60261285611608	bayes_pls_golite062009
primary active transmembrane transporter activity	7.59280303111267	bayes_pls_golite062009
active transmembrane transporter activity	7.51217805691059	bayes_pls_golite062009
ATPase activity, coupled	6.95724531600418	bayes_pls_golite062009
ATPase activity	6.62620720611918	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.31173441402571	bayes_pls_golite062009
pyrophosphatase activity	6.23822548232138	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.21828378422716	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.21791205758921	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.46058403247103	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	5.44734032398062	bayes_pls_golite062009
ion transmembrane transporter activity	4.84048533553771	bayes_pls_golite062009
hydrolase activity	4.5940497987178	bayes_pls_golite062009
anion transmembrane transporter activity	4.24238019900305	bayes_pls_golite062009
transporter activity	4.16850252614298	bayes_pls_golite062009
transmembrane transporter activity	4.07281957844021	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	3.94646473062144	bayes_pls_golite062009
cation transmembrane transporter activity	3.74189499327501	bayes_pls_golite062009
substrate-specific transporter activity	3.61142533583701	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	2.76198656053365	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	2.76198656053365	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.19359047382598	bayes_pls_golite062009
sugar transmembrane transporter activity	2.147054904918	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.96050114748502	bayes_pls_golite062009
maltose-transporting ATPase activity	1.62768691451517	bayes_pls_golite062009
oligosaccharide-transporting ATPase activity	1.62768691451517	bayes_pls_golite062009
oligosaccharide transmembrane transporter activity	1.62768691451517	bayes_pls_golite062009
disaccharide transmembrane transporter activity	1.5877861023737	bayes_pls_golite062009
alpha-glucoside transmembrane transporter activity	1.5877861023737	bayes_pls_golite062009
maltose transmembrane transporter activity	1.5877861023737	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.58031187867436	bayes_pls_golite062009
glucoside transmembrane transporter activity	1.54998466398412	bayes_pls_golite062009
iron ion transmembrane transporter activity	0.635517449756608	bayes_pls_golite062009
secondary active transmembrane transporter activity	0.634824157502542	bayes_pls_golite062009
catalytic activity	0.350058049038907	bayes_pls_golite062009
solute:cation symporter activity	0.0914244193736007	bayes_pls_golite062009
symporter activity	0.0914244193736007	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [270-536]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGTTLLQGWR DPDDRLHSRI CDTVLIVLAL LLLLPPLLAV IVDGVNRQLP EVLAQPVLWQ  60
   61 ALWTSLRIAL AAGVLCVVLT MMLLWSSREL RARQKMLAGQ VLEMSGMLIL AMPGIVLATG 120
  121 FFLLLNNTIG LPQSADGIVI FTNALMAIPY ALKVLENPMR DITARYSMLC QSLGIEGWSR 180
  181 LKVVELRALK RPLAQALAFA CVLSIGDFGV VALFGNDDFR TLPFYLYQQI GSYRSQDGAV 240
  241 TALILLLLCF LLFTVIEKLP GRNVKTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.30103
Match:	2onkC
Description:	No description for 2onkC was found.

Predicted functions:

Term	Confidence	Notes
sulfate transmembrane transporter activity	10.9565051799528	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	8.73635781369483	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	7.98776119907207	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	7.98726234902655	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	7.98726234902655	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	7.97287417765536	bayes_pls_golite062009
primary active transmembrane transporter activity	7.96249144456164	bayes_pls_golite062009
active transmembrane transporter activity	7.8678894318504	bayes_pls_golite062009
ATPase activity, coupled	7.29227234008448	bayes_pls_golite062009
ATPase activity	6.94069583578738	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.59903874016214	bayes_pls_golite062009
pyrophosphatase activity	6.52169210550643	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.50067149801529	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.5003333073452	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	5.79272438461837	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.78398318541319	bayes_pls_golite062009
ion transmembrane transporter activity	5.07829337366931	bayes_pls_golite062009
hydrolase activity	4.78607811092587	bayes_pls_golite062009
anion transmembrane transporter activity	4.52297088726018	bayes_pls_golite062009
transporter activity	4.47791794099048	bayes_pls_golite062009
transmembrane transporter activity	4.39634414867723	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	4.26804338154829	bayes_pls_golite062009
substrate-specific transporter activity	3.91409799494188	bayes_pls_golite062009
cation transmembrane transporter activity	3.91336745536039	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	2.9609821483404	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	2.9609821483404	bayes_pls_golite062009
sugar transmembrane transporter activity	2.67115360425434	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.42763030383098	bayes_pls_golite062009
maltose-transporting ATPase activity	2.14010989459818	bayes_pls_golite062009
oligosaccharide-transporting ATPase activity	2.14010989459818	bayes_pls_golite062009
oligosaccharide transmembrane transporter activity	2.14010989459818	bayes_pls_golite062009
alpha-glucoside transmembrane transporter activity	2.09224118357857	bayes_pls_golite062009
maltose transmembrane transporter activity	2.09224118357857	bayes_pls_golite062009
disaccharide transmembrane transporter activity	2.09224118357857	bayes_pls_golite062009
glucoside transmembrane transporter activity	2.04706530621258	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.98807799932923	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.59729360434602	bayes_pls_golite062009
secondary active transmembrane transporter activity	0.96228415837358	bayes_pls_golite062009
iron ion transmembrane transporter activity	0.75761030349885	bayes_pls_golite062009
symporter activity	0.483541714040201	bayes_pls_golite062009
solute:cation symporter activity	0.483541714040201	bayes_pls_golite062009
catalytic activity	0.427775057748038	bayes_pls_golite062009
maltooligosaccharide-importing ATPase activity	0.16532450344344	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.0291867591868584	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	0.0202682073710961	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: