YRC Public Data Repository - Protein Structure Prediction

Protein:	FADA_ECOLI, THIK...
Organism:	Escherichia coli
Length:	387 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FADA_ECOLI, THIK....

Description	E-value	Query Range	Subject Range
gi\|59710631, gi\|... - gi\|59710631\|ref\|YP_203407.1\| acetyl-CoA acetyltransferase [Vibrio fischeri ES114], gi\|59478732\|gb\|AA...	392.0	[0..1]	[386..23]
gi\|90413717, gi\|... - gi\|90413717\|ref\|ZP_01221705.1\| acetyl-CoA acetyltransferase [Photobacterium profundum 3TCK], gi\|9032...	386.0	[0..1]	[387..1]
FADA_PHOPR - 3-ketoacyl-CoA thiolase OS=Photobacterium profundum GN=fadA PE=3 SV=1 FADA_PHOPR - 3-ketoacyl-CoA thiolase OS=Photobacterium profundum (strain SS9) GN=fadA PE=3 SV=1	385.0	[0..1]	[387..1]
FADA_IDILO - 3-ketoacyl-CoA thiolase OS=Idiomarina loihiensis GN=fadA PE=3 SV=1 FADA_IDILO - 3-ketoacyl-CoA thiolase OS=Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) GN=fadA P...	383.0	[0..1]	[387..1]
gi\|77996685, gi\|... - gi\|78044570\|ref\|YP_360188.1\| acetyl-CoA acetyltransferase [Carboxydothermus hydrogenoformans Z-2901]...	383.0	[0..1]	[387..1]
gi\|238790599, gi... - gi\|77973703\|ref\|ZP_00829249.1\| COG0183: Acetyl-CoA acetyltransferase [Yersinia frederiksenii ATCC 33...	378.0	[0..1]	[387..1]
gi\|85711012, gi\|... - gi\|85711012\|ref\|ZP_01042073.1\| acetyl-CoA acetyltransferase [Idiomarina baltica OS145], gi\|85695416\|...	377.0	[0..1]	[387..1]
gi\|90437631, gi\|... - gi\|90581110\|ref\|ZP_01236909.1\| acetyl-CoA acetyltransferase [Vibrio angustum S14], gi\|90437631\|gb\|EA...	377.0	[0..1]	[387..1]
gi\|89074688, gi\|... - gi\|89074688\|ref\|ZP_01161146.1\| acetyl-CoA acetyltransferase [Photobacterium sp. SKA34], gi\|89049452\|...	377.0	[0..1]	[387..1]

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Predicted Domain #1

Region A:
Residues: [1-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQVVIVDAI RTPMGRSKGG AFRNVRAEDL SAHLMRSLLA RNPALEAAAL DDIYWGCVQQ  60
   61 TLEQGFNIAR NAALLAEVPH SVPAVTVNRL CGSSMQALHD AARMIMTGDA QACLVGGVEH 120
  121 MGHVPMSHGV DFHPGLSRNV AKAAGMMGLT AEMLARMHGI SREMQDAFAA RSHARAWAAT 180
  181 QSAAFKNEII PTGGHDADGV LKQFNYDEVI RPETTVEALA TLRPAFDPVN GMVTAGTSSA 240
  241 LSDGAAAMLV MSESRAHELG LKPRARVRSM AVVGCDPSIM GYGPVPASKL ALKKAGLSAS 300
  301 DIGVFEMNEA FAAQILPCIK DLGLIEQIDE KINLNGGAIA LGHPLGCSGA RISTTLLNLM 360
  361 ERKDVQFGLA TMCIGLGQGI ATVFERV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	103.0
Match:	1wdkC
Description:	fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form I (native2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetyl-CoA C-acyltransferase activity	8.08119341370748	bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity	7.45371477074071	bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity	5.63866392580915	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.96408928512745	bayes_pls_golite062009
fatty acid synthase activity	3.79121338118181	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] synthase activity	3.71249191203055	bayes_pls_golite062009
C-acyltransferase activity	3.27532895419051	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.14957464437124	bayes_pls_golite062009
acyltransferase activity	3.06879684191353	bayes_pls_golite062009
transferase activity	2.15834234036431	bayes_pls_golite062009
catalytic activity	2.14505178497871	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.87304265492939	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	1.77798276950874	bayes_pls_golite062009
acetyl-CoA C-acetyltransferase activity	1.50839304016514	bayes_pls_golite062009
C-acetyltransferase activity	1.19264084089277	bayes_pls_golite062009
hydroxymethylglutaryl-CoA synthase activity	1.16785899347652	bayes_pls_golite062009
acetyltransferase activity	0.6519546920419	bayes_pls_golite062009
binding	0.415385255550741	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.21899828831708	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: