YRC Public Data Repository - Protein Structure Prediction

Protein:	PTFAH_ECOLI, PTF...
Organism:	Escherichia coli
Length:	376 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTFAH_ECOLI, PTF....

Description	E-value	Query Range	Subject Range
gi\|91225421, gi\|... - gi\|91225421\|ref\|ZP_01260543.1\| PTS system, fructose-specific IIA/FPR component [Vibrio alginolyticus...	307.0	[0..1]	[375..1]
gi\|75242986, gi\|... - gi\|75242986\|ref\|ZP_00726692.1\| COG4668: Mannitol/fructose-specific phosphotransferase system, IIA do... gi\|110343971, gi... - gi\|110642379\|ref\|YP_670109.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia coli 5...	306.0	[0..1]	[376..1]
gi\|194539702, gi... - gi\|75857155\|ref\|ZP_00764773.1\| COG4668: Mannitol/fructose-specific phosphotransferase system, IIA do...	305.0	[0..1]	[375..1]
gi\|26248550, gi\|... - gi\|26248550\|ref\|NP_754590.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia coli CF... gi\|227835574, gi... - gi\|227887224\|ref\|ZP_04005029.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia coli...	303.0	[0..1]	[376..1]
gi\|15802725, gi\|... - gi\|15802725\|ref\|NP_288752.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia coli O1... gi\|25287867 - gi\|25287867\|pir\|\|G85855 PTS system, fructose-specific IIA/fpr component [imported] - Escherichia col...	303.0	[0..1]	[376..1]
gi\|188494908, gi... - gi\|75514492\|ref\|ZP_00736770.1\| COG4668: Mannitol/fructose-specific phosphotransferase system, IIA do... gi\|75196213, gi\|... - gi\|75196213\|ref\|ZP_00706283.1\| COG4668: Mannitol/fructose-specific phosphotransferase system, IIA do... gi\|124501802, gi... - gi\|124526746\|ref\|ZP_01698655.1\| phosphocarrier, HPr family [Escherichia coli B], gi\|124501802\|gb\|EA... gi\|169754443, gi... - gi\|170019515\|ref\|YP_001724469.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia col...	303.0	[0..1]	[376..1]
gi\|81241684, gi\|... - gi\|82777536\|ref\|YP_403885.1\| bifunctional fructose-specific PTS IIA/HPr protein [Shigella dysenteria...	303.0	[0..1]	[376..1]
gi\|73856168, gi\|... - gi\|74312691\|ref\|YP_311110.1\| bifunctional fructose-specific PTS IIA/HPr protein [Shigella sonnei Ss0...	303.0	[0..1]	[376..1]
gi\|115513492, gi... - gi\|117624368\|ref\|YP_853281.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia coli A... gi\|226901003, gi... - gi\|237704637\|ref\|ZP_04535118.1\| fused fructose-specific PTS enzyme IIA component and HPr component [... gi\|218559089, gi... - gi\|218559089\|ref\|YP_002392002.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia col... gi\|91073031, gi\|... - gi\|91211457\|ref\|YP_541443.1\| bifunctional fructose-specific PTS IIA/HPr protein [Escherichia coli UT...	302.0	[0..1]	[376..1]
gi\|77960394, gi\|... - gi\|77960394\|ref\|ZP_00824267.1\| COG4668: Mannitol/fructose-specific phosphotransferase system, IIA do...	302.0	[0..1]	[376..1]

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Predicted Domain #1

Region A:
Residues: [1-142]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQLSVQDIH PGEKAGDKEE AIRQVAAALV QAGNVAEGYV NGMLAREQQT STFLGNGIAI  60
   61 PHGTTDTRDQ VLKTGVQVFQ FPEGVTWGDG QVAYVAIGIA ASSDEHLGLL RQLTHVLSDD 120
  121 SVAEQLKSAT TAEELRALLM GE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.30103
Match:	1a3aA
Description:	Phosphotransferase IIa-mannitol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	4.89047341597444	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	3.92377913213665	bayes_pls_golite062009
transporter activity	2.16741930408232	bayes_pls_golite062009
transmembrane transporter activity	2.05879816720019	bayes_pls_golite062009
active transmembrane transporter activity	1.87457143976439	bayes_pls_golite062009
substrate-specific transporter activity	1.82451780056478	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.7251575499811	bayes_pls_golite062009
binding	0.396676636991646	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.19707628828681	bayes_pls_golite062009
ion transmembrane transporter activity	0.12881601139602	bayes_pls_golite062009
anion transmembrane transporter activity	0.10209580008722	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [143-267]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQSEQLKLDN EMLTLDIVAS DLLTLQALNA ARLKEAGAVD ATFVTKAINE QPLNLGQGIW  60
   61 LSDSAEGNLR SAIAVSRAAN AFDVDGETAA MLVSVAMNDD QPIAVLKRLA DLLLDNKADR 120
  121 LLKAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.221849
Match:	2r4qA
Description:	No description for 2r4qA was found.

Predicted Domain #3

Region A:
Residues: [268-376]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATLLALLTS DDAPTDDVLS AEFVVRNEHG LHARPGTMLV NTIKQFNSDI TVTNLDGTGK  60
   61 PANGRSLMKV VALGVKKGHR LRFTAQGADA EQALKAIGDA IAAGLGEGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.30103
Match:	1kklH
Description:	Histidine-containing phosphocarrier protein (HPr)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	5.70778264466435	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	4.7398246519874	bayes_pls_golite062009
transporter activity	1.94557075462337	bayes_pls_golite062009
transmembrane transporter activity	1.8285077384404	bayes_pls_golite062009
active transmembrane transporter activity	1.73790085561506	bayes_pls_golite062009
substrate-specific transporter activity	1.57976971135135	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.4723961195197	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.97685688328333	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.61783246115451	bayes_pls_golite062009
binding	0.569728786489819	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: