YRC Public Data Repository - Protein Structure Prediction

Protein:	NLPA_ECOLI
Organism:	Escherichia coli
Length:	272 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NLPA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|74474895 - gi\|74474895\|dbj\|BAE44432.1\| antigenic protein Et 28 [Edwardsiella tarda]	241.0	[0..4]	[272..3]
gi\|56126775, gi\|... - gi\|56412518\|ref\|YP_149593.1\| DL-methionine transporter substrate-binding subunit [Salmonella enteric... gi\|197361453, gi... - gi\|197361453\|ref\|YP_002141089.1\| DL-methionine transporter substrate-binding subunit [Salmonella ent...	239.0	[0..1]	[272..1]
METQ_SALTY - D-methionine-binding lipoprotein metQ OS=Salmonella typhimurium GN=metQ PE=3 SV=1 gi\|224466619, gi... - gi\|224582092\|ref\|YP_002635890.1\| putative lipoprotein precursor [Salmonella enterica subsp. enterica... gi\|204927300, gi... - gi\|204927300\|ref\|ZP_03218502.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipop... gi\|199604040, gi... - gi\|200386942\|ref\|ZP_03213554.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipop... gi\|207855763, gi... - gi\|207855763\|ref\|YP_002242414.1\| DL-methionine transporter substrate-binding subunit [Salmonella ent... gi\|205271363, gi... - gi\|205351582\|ref\|YP_002225383.1\| DL-methionine transporter substrate-binding subunit [Salmonella ent... gi\|62178814, gi\|... - gi\|62178814\|ref\|YP_215231.1\| DL-methionine transporter substrate-binding subunit [Salmonella enteric... METQ_SALTY - D-methionine-binding lipoprotein MetQ OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720... gi\|197213623, gi... - gi\|197249920\|ref\|YP_002145250.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipo... gi\|194736374, gi... - gi\|194736374\|ref\|YP_002113268.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipo... gi\|197940543, gi... - gi\|198246027\|ref\|YP_002214206.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipo... gi\|197240061, gi... - gi\|197261806\|ref\|ZP_03161880.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipop... gi\|194444076, gi... - gi\|194444076\|ref\|YP_002039485.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipo... gi\|168823083, gi... - gi\|205340616\|gb\|EDZ27380.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote... gi\|194469222, gi... - gi\|194469222\|ref\|ZP_03075206.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipop... gi\|194408651, gi... - gi\|194450347\|ref\|YP_002044235.1\| DL-methionine transporter substrate-binding subunit [Salmonella ent... gi\|238911311 - gi\|238911311\|ref\|ZP_04655148.1\| DL-methionine transporter substrate-binding subunit [Salmonella ente... lcl\|NC_016856.1_... - [gene=metQ] [protein=DL-methionine transporter substrate-binding subunit] [protein_id=YP_005235916.1... gi\|205336226, gi... - gi\|205336226\|gb\|EDZ22990.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote... gi\|197291660, gi... - gi\|197291660\|gb\|EDY31010.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote... gi\|195632682, gi... - gi\|195632682\|gb\|EDX51136.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote... gi\|205346915, gi... - gi\|205346915\|gb\|EDZ33546.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote... METQ_SALTY - D-methionine-binding lipoprotein metQ OS=Salmonella typhimurium GN=metQ PE=3 SV=1 gi\|167553339, gi... - gi\|205322180\|gb\|EDZ10019.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote... gi\|161361984, gi... - gi\|161612620\|ref\|YP_001586585.1\| DL-methionine transporter substrate-binding subunit [Salmonella ent... gi\|205335212, gi... - gi\|205335212\|gb\|EDZ21976.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote... gi\|205331324, gi... - gi\|205331324\|gb\|EDZ18088.1\| D-methionine ABC transporter, periplasmic D-methionine-binding lipoprote...	238.0	[0..1]	[272..1]
METQ_SALTI - D-methionine-binding lipoprotein MetQ OS=Salmonella typhi GN=metQ PE=3 SV=1 gi\|213615740 - gi\|213615740\|ref\|ZP_03371566.1\| DL-methionine transporter substrate-binding subunit [Salmonella ente... gi\|213865225 - gi\|213865225\|ref\|ZP_03387344.1\| DL-methionine transporter substrate-binding subunit [Salmonella ente... gi\|29136410, gi\|... - gi\|29140786\|ref\|NP_804128.1\| DL-methionine transporter substrate-binding subunit [Salmonella enteric... gi\|214003515 - gi\|214003515\|ref\|ZP_03414250.1\| DL-methionine transporter substrate-binding subunit [Salmonella ente... gi\|16759237 - gi\|16759237\|ref\|NP_454854.1\| DL-methionine transporter substrate-binding subunit [Salmonella enteric... METQ_SALTI - D-methionine-binding lipoprotein metQ OS=Salmonella typhi GN=metQ PE=3 SV=1 gi\|213051825 - gi\|213051825\|ref\|ZP_03344703.1\| DL-methionine transporter substrate-binding subunit [Salmonella ente...	237.0	[0..1]	[272..1]
gi\|36784121, gi\|... - gi\|37524696\|ref\|NP_928040.1\| DL-methionine transporter substrate-binding subunit [Photorhabdus lumin...	237.0	[0..1]	[272..1]
gi\|77977719, gi\|... - gi\|77977719\|ref\|ZP_00833160.1\| COG1464: ABC-type metal ion transport system, periplasmic component/s...	237.0	[0..1]	[272..1]
gi\|238787206, gi... - gi\|77972740\|ref\|ZP_00828299.1\| COG1464: ABC-type metal ion transport system, periplasmic component/s...	237.0	[0..1]	[272..1]
gi\|238784907, gi... - gi\|77957717\|ref\|ZP_00821766.1\| COG1464: ABC-type metal ion transport system, periplasmic component/s...	237.0	[0..1]	[272..1]
gi\|149290541, gi... - gi\|149366927\|ref\|ZP_01888960.1\| putative lipoprotein [Yersinia pestis CA88-4125], gi\|149290541\|gb\|ED... gi\|229837779, gi... - gi\|229837779\|ref\|ZP_04457939.1\| putative lipoprotein [Yersinia pestis Pestoides A], gi\|229704156\|gb\|... gi\|145210618, gi... - gi\|145598922\|ref\|YP_001162998.1\| DL-methionine transporter substrate-binding subunit [Yersinia pesti... gi\|229841001, gi... - gi\|229841001\|ref\|ZP_04461160.1\| putative lipoprotein [Yersinia pestis biovar Orientalis str. PEXU2],... gi\|229843102, gi... - gi\|229843102\|ref\|ZP_04463252.1\| putative lipoprotein [Yersinia pestis biovar Orientalis str. India 1... gi\|165921021, gi... - gi\|165927125\|ref\|ZP_02222957.1\| D-methionine ABC transporter, periplasmic D-methionine-binding prote... METQ_YERPE - D-methionine-binding lipoprotein MetQ OS=Yersinia pestis GN=metQ PE=3 SV=1 gi\|45442546, gi\|... - gi\|45442546\|ref\|NP_994085.1\| DL-methionine transporter substrate-binding subunit [Yersinia pestis bi... gi\|21960026, gi\|... - gi\|22126982\|ref\|NP_670405.1\| DL-methionine transporter substrate-binding subunit [Yersinia pestis KI... gi\|218928240, gi... - gi\|218928240\|ref\|YP_002346115.1\| DL-methionine transporter substrate-binding subunit [Yersinia pesti... gi\|77633966, gi\|... - gi\|77633966\|ref\|ZP_00796078.1\| COG1464: ABC-type metal ion transport system, periplasmic component/s... gi\|108776736, gi... - gi\|229903531\|ref\|ZP_04518644.1\| putative lipoprotein [Yersinia pestis Nepal516], gi\|229679301\|gb\|EEO... gi\|166211644, gi... - gi\|166211644\|ref\|ZP_02237679.1\| D-methionine ABC transporter, periplasmic D-methionine-binding prote... gi\|166011933, gi... - gi\|166011933\|ref\|ZP_02232831.1\| D-methionine ABC transporter, periplasmic D-methionine-binding prote... gi\|167419837, gi... - gi\|167419837\|ref\|ZP_02311590.1\| D-methionine ABC transporter, periplasmic D-methionine-binding prote... gi\|167050758, gi... - gi\|167400050\|ref\|ZP_02305568.1\| D-methionine ABC transporter, periplasmic D-methionine-binding prote... gi\|167470136 - gi\|167470136\|ref\|ZP_02334840.1\| D-methionine ABC transporter, periplasmic D-methionine-binding prote... gi\|167055668, gi... - gi\|167425268\|ref\|ZP_02317021.1\| D-methionine ABC transporter, periplasmic D-methionine-binding prote... gi\|165912227, gi... - gi\|89105162\|ref\|ZP_01177687.1\| COG1464: ABC-type metal ion transport system, periplasmic component/s... gi\|108806545, gi... - gi\|108806545\|ref\|YP_650461.1\| DL-methionine transporter substrate-binding subunit [Yersinia pestis A...	236.0	[0..1]	[272..1]
gi\|152958756, gi... - gi\|77630009\|ref\|ZP_00792595.1\| COG1464: ABC-type metal ion transport system, periplasmic component/s...	236.0	[0..1]	[272..1]

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Predicted Domain #1

Region A:
Residues: [1-272]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLTTHHLRT GAALLLAGIL LAGCDQSSSD AKHIKVGVIN GAEQDVAEVA KKVAKEKYGL  60
   61 DVELVGFSGS LLPNDATNHG ELDANVFQHR PFLEQDNQAH GYKLVAVGNT FVFPMAGYSK 120
  121 KIKTVAQIKE GATVAIPNDP TNLGRALLLL QKEKLITLKE GKGLLPTALD ITDNPRHLQI 180
  181 MELEGAQLPR VLDDPKVDVA IISTTYIQQT GLSPVHDSVF IEDKNSPYVN ILVAREDNKN 240
  241 AENVKEFLQS YQSPEVAKAA ETIFNGGAVP GW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.09691
Match:	1xs5A
Description:	The Crystal Structure of Lipoprotein Tp32 from Treponema pallidum
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	3.92658561501282	bayes_pls_golite062009
transmembrane transporter activity	3.71430307970333	bayes_pls_golite062009
active transmembrane transporter activity	3.25041295044206	bayes_pls_golite062009
primary active transmembrane transporter activity	3.11737631998936	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	3.11705111590472	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	3.10446376809293	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	3.10446376809293	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	3.10218613709054	bayes_pls_golite062009
substrate-specific transporter activity	3.08939958030684	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.51750037542166	bayes_pls_golite062009
ATPase activity, coupled	2.46598025840834	bayes_pls_golite062009
ATPase activity	2.22107983126774	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.16305304794278	bayes_pls_golite062009
pyrophosphatase activity	2.08989799392446	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.06979125310099	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.06762097920234	bayes_pls_golite062009
ion transmembrane transporter activity	1.57698908250492	bayes_pls_golite062009
binding	1.54172013140566	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	0.88623763826001	bayes_pls_golite062009
hydrolase activity	0.770701934726697	bayes_pls_golite062009
anion transmembrane transporter activity	0.55229829618114	bayes_pls_golite062009
amine transmembrane transporter activity	0.372828805396439	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.204574649410409	bayes_pls_golite062009
cation transmembrane transporter activity	0.067986302221225	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: