YRC Public Data Repository - Protein Structure Prediction

Protein:	MAO2_ECOLI
Organism:	Escherichia coli
Length:	759 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAO2_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77977000, gi\|... - gi\|77977000\|ref\|ZP_00832462.1\| COG0281: Malic enzyme [Yersinia intermedia ATCC 29909], gi\|238792065\|...	887.0	[0..1]	[759..1]
gi\|227887499, gi... - gi\|227887499\|ref\|ZP_04005304.1\| malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) [Esche... gi\|226901343, gi... - gi\|237704977\|ref\|ZP_04535458.1\| malic enzyme [Escherichia sp. 3_2_53FAA], gi\|226901343\|gb\|EEH87602.1... gi\|218366167, gi... - gi\|218559398\|ref\|YP_002392311.1\| malic enzyme [Escherichia coli S88], gi\|218366167\|emb\|CAR03913.1\| p... gi\|115513783, gi... - gi\|117624659\|ref\|YP_853572.1\| malic enzyme [Escherichia coli APEC O1], gi\|115513783\|gb\|ABJ01858.1\| N... gi\|91211792, gi\|... - gi\|91211792\|ref\|YP_541778.1\| malic enzyme [Escherichia coli UTI89], gi\|91073366\|gb\|ABE08247.1\| NADP-... gi\|26248830, gi\|... - gi\|26248830\|ref\|NP_754870.1\| malic enzyme [Escherichia coli CFT073], gi\|26109236\|gb\|AAN81438.1\|AE016...	886.0	[0..1]	[759..1]
gi\|168748488, gi... - gi\|188017098\|gb\|EDU55220.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4113], gi\|16874848... gi\|189356564, gi... - gi\|189356564\|gb\|EDU74983.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4401], gi\|16875622... gi\|189368375, gi... - gi\|189368375\|gb\|EDU86791.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4501], gi\|16876106... gi\|189362223, gi... - gi\|189362223\|gb\|EDU80642.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4486], gi\|16876854... gi\|168773633, gi... - gi\|187770568\|gb\|EDU34412.1\| malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) [Escherich... gi\|189003269, gi... - gi\|189003269\|gb\|EDU72255.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4076], gi\|16877842... gi\|13362795, gi\|... - gi\|15832579\|ref\|NP_311352.1\| malic enzyme [Escherichia coli O157:H7 str. Sakai], gi\|13362795\|dbj\|BAB... gi\|217327774, gi... - gi\|217327774\|ref\|ZP_03443857.1\| NADP-dependent malic enzyme [Escherichia coli O157:H7 str. TW14588],... gi\|218370905, gi... - gi\|218700919\|ref\|YP_002408548.1\| malic enzyme [Escherichia coli IAI39], gi\|218370905\|emb\|CAR18724.1\|... gi\|218705961, gi... - gi\|218705961\|ref\|YP_002413480.1\| malic enzyme [Escherichia coli UMN026], gi\|218433058\|emb\|CAR13953.1... gi\|13362795, gi\|... - gi\|15832579\|ref\|NP_311352.1\| phosphate acetyltransferase [Escherichia coli O157:H7], gi\|13362795\|dbj... gi\|209763848, gi... - pir\|\|E91044 probable multimodular enzyme [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|189372279, gi... - gi\|189372279\|gb\|EDU90695.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC869], gi\|168787800... gi\|168798825, gi... - gi\|189378538\|gb\|EDU96954.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC508], gi\|168798825... gi\|82777840, gi\|... - gi\|82777840\|ref\|YP_404189.1\| malic enzyme [Shigella dysenteriae Sd197], gi\|81241988\|gb\|ABB62698.1\| p... gi\|170517469, gi... - gi\|170679751\|ref\|YP_001744645.1\| malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) [Esch... gi\|195936604 - gi\|195936604\|ref\|ZP_03081986.1\| malic enzyme [Escherichia coli O157:H7 str. EC4024] gi\|208728397, gi... - gi\|208808596\|ref\|ZP_03250933.1\| NADP-dependent malic enzyme [Escherichia coli O157:H7 str. EC4206], ... gi\|208813174, gi... - gi\|208813174\|ref\|ZP_03254503.1\| NADP-dependent malic enzyme [Escherichia coli O157:H7 str. EC4045], ... gi\|208742015, gi... - gi\|208821892\|ref\|ZP_03262212.1\| NADP-dependent malic enzyme [Escherichia coli O157:H7 str. EC4042], ... gi\|209159466, gi... - gi\|209398066\|ref\|YP_002271931.1\| NADP-dependent malic enzyme [Escherichia coli O157:H7 str. EC4115],... gi\|190906796, gi... - gi\|75240112\|ref\|ZP_00724071.1\| COG0281: Malic enzyme [Escherichia coli F11], gi\|191172932\|ref\|ZP_030... gi\|74312988, gi\|... - gi\|74312988\|ref\|YP_311407.1\| malic enzyme [Shigella sonnei Ss046], gi\|73856465\|gb\|AAZ89172.1\| putati... gi\|193068428, gi... - gi\|75237794\|ref\|ZP_00721810.1\| COG0281: Malic enzyme [Escherichia coli E110019], gi\|193068428\|ref\|ZP... gi\|254593807, gi... - gi\|254794407\|ref\|YP_003079244.1\| malic enzyme predicted oxidoreductase and predicted phosphotransace...	886.0	[0..1]	[759..1]
gi\|218554986, gi... - gi\|218554986\|ref\|YP_002387899.1\| malic enzyme [Escherichia coli IAI1], gi\|218361754\|emb\|CAQ99351.1\| ... gi\|218352821, gi... - gi\|218696089\|ref\|YP_002403756.1\| malic enzyme [Escherichia coli 55989], gi\|218352821\|emb\|CAU98609.1\|... gi\|209913194, gi... - gi\|209919935\|ref\|YP_002294019.1\| malic enzyme [Escherichia coli SE11], gi\|209913194\|dbj\|BAG78268.1\| ... gi\|75211424, gi\|... - gi\|75211424\|ref\|ZP_00711514.1\| COG0281: Malic enzyme [Escherichia coli B171], gi\|194427294\|ref\|ZP_03... gi\|75229215, gi\|... - gi\|75229215\|ref\|ZP_00715783.1\| COG0281: Malic enzyme [Escherichia coli B7A], gi\|191167620\|ref\|ZP_030... gi\|157078504, gi... - gi\|75187207\|ref\|ZP_00700474.1\| COG0281: Malic enzyme [Escherichia coli E24377A], gi\|157156474\|ref\|YP... gi\|192927600, gi... - gi\|75257266\|ref\|ZP_00728790.1\| COG0281: Malic enzyme [Escherichia coli E22], gi\|193064717\|ref\|ZP_030... gi\|82544912, gi\|... - gi\|82544912\|ref\|YP_408859.1\| malic enzyme [Shigella boydii Sb227], gi\|81246323\|gb\|ABB67031.1\| putati...	886.0	[0..1]	[759..1]
gi\|238799203, gi... - gi\|77960159\|ref\|ZP_00824047.1\| COG0281: Malic enzyme [Yersinia mollaretii ATCC 43969], gi\|238799203\|...	886.0	[0..1]	[759..1]
gi\|110344227, gi... - gi\|110642635\|ref\|YP_670365.1\| malic enzyme [Escherichia coli 536], gi\|110344227\|gb\|ABG70464.1\| NADP-...	886.0	[0..1]	[759..1]
gi\|77974595, gi\|... - gi\|77974595\|ref\|ZP_00830134.1\| COG0281: Malic enzyme [Yersinia frederiksenii ATCC 33641], gi\|2387880...	886.0	[0..1]	[759..1]
gi\|194432085, gi... - gi\|83570677\|ref\|ZP_00922120.1\| COG0281: Malic enzyme [Shigella dysenteriae 1012], gi\|194432085\|ref\|Z...	885.0	[0..1]	[759..1]
gi\|24113792, gi\|... - gi\|24113792\|ref\|NP_708302.1\| malic enzyme [Shigella flexneri 2a str. 301], gi\|24052874\|gb\|AAN44009.1... gi\|110806396, gi... - gi\|110806396\|ref\|YP_689916.1\| malic enzyme [Shigella flexneri 5 str. 8401], gi\|110615944\|gb\|ABF04611... gi\|30042098, gi\|... - gi\|30063843\|ref\|NP_838014.1\| malic enzyme [Shigella flexneri 2a str. 2457T], gi\|30042098\|gb\|AAP17824...	885.0	[0..1]	[759..1]
gi\|15802985, gi\|... - gi\|15802985\|ref\|NP_289015.1\| malic enzyme [Escherichia coli O157:H7 EDL933], gi\|12516838\|gb\|AAG57572... gi\|25501122 - pir\|\|H85888 probable multimodular enzyme Z3719 [imported] - Escherichia coli (strain O157:H7, substr...	885.0	[0..1]	[759..1]

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Predicted Domain #1

Region A:
Residues: [1-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDQLKQSAL DFHEFPVPGK IQVSPTKPLA TQRDLALAYS PGVAAPCLEI EKDPLKAYKY  60
   61 TARGNLVAVI SNGTAVLGLG NIGALAGKPV MEGKGVLFKK FAGIDVFDIE VDELDPDKFI 120
  121 EVVAALEPTF GGINLEDIKA PECFYIEQKL RERMNIPVFH DDQHGTAIIS TAAILNGLRV 180
  181 VEKNISDVRM VVSGAGAAAI ACMNLLVALG LQKHNIVVCD SKGVIYQGRE PNMAETKAAY 240
  241 AVVDDGKRTL DDVIEGADIF LGCSGPKVLT QEMVKKMARA PMILALANPE PEILPPLAKE 300
  301 VRPDAIICTG RSDYPNQVNN VLCFPFIFRG ALDVGATAIN EEMKLAAVRA IAELAHAEQS 360
  361 EVVASAYGDQ DLSFGPEYII PKPFDPRLIV KIAPAVAKAA MESGVATRPI ADFDVYIDKL 420
  421 TEFVYKTNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.0
Match:	1ww8A
Description:	No description for 1ww8A was found.

Predicted Domain #2

Region A:
Residues: [430-759]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FMKPIFSQAR KAPKRVVLPE GEEARVLHAT QELVTLGLAK PILIGRPNVI EMRIQKLGLQ  60
   61 IKAGVDFEIV NNESDPRFKE YWTEYFQIMK RRGVTQEQAQ RALISNPTVI GAIMVQRGEA 120
  121 DAMICGTVGD YHEHFSVVKN VFGYRDGVHT AGAMNALLLP SGNTFIADTY VNDEPDAEEL 180
  181 AEITLMAAET VRRFGIEPRV ALLSHSNFGS SDCPSSSKMR QALELVRERA PELMIDGEMH 240
  241 GDAALVEAIR NDRMPDSSLK GSANILVMPN MEAARISYNL LRVSSSEGVT VGPVLMGVAK 300
  301 PVHVLTPIAS VRRIVNMVAL AVVEAQTQPL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.69897
Match:	1r5jA
Description:	Crystal Structure of a Phosphotransacetylase from Streptococcus pyogenes
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
isocitrate dehydrogenase activity	4.33689457213697	bayes_pls_golite062009
isocitrate dehydrogenase (NAD+) activity	3.02706047421851	bayes_pls_golite062009
catalytic activity	2.71251959637136	bayes_pls_golite062009
isocitrate dehydrogenase (NADP+) activity	2.58800454678946	bayes_pls_golite062009
malate dehydrogenase activity	2.5212640632502	bayes_pls_golite062009
oxidoreductase activity	1.34383793575786	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.23338300186555	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.23134321553105	bayes_pls_golite062009
acetyltransferase activity	0.475874744828042	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: