YRC Public Data Repository - Protein Structure Prediction

Protein:	KUP_ECOLI
Organism:	Escherichia coli
Length:	622 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KUP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115376911, gi... - gi\|115376911\|ref\|ZP_01464132.1\| K+ potassium transporter [Stigmatella aurantiaca DW4/3-1], gi\|115366...	614.0	[0..4]	[622..32]
KUP_MYXXD - Probable potassium transport system protein kup OS=Myxococcus xanthus (strain DK 1622) GN=kup PE=3 S...	613.0	[0..4]	[622..31]
KUP2_CHRVO - Probable potassium transport system protein kup 2 OS=Chromobacterium violaceum GN=kup2 PE=3 SV=1 KUP2_CHRVO - Probable potassium transport system protein kup 2 OS=Chromobacterium violaceum (strain ATCC 12472 / ...	606.0	[0..1]	[622..1]
gi\|23016322 - gi\|23016322\|ref\|ZP_00056079.1\| COG3158: K+ transporter [Magnetospirillum magnetotacticum MS-1]	605.0	[0..2]	[622..7]
KUP1_GEOSL - Probable potassium transport system protein kup 1 OS=Geobacter sulfurreducens (strain ATCC 51573 / D... KUP1_GEOSL - Probable potassium transport system protein kup 1 OS=Geobacter sulfurreducens GN=kup1 PE=3 SV=1	601.0	[0..7]	[622..13]
KUP_AROAE - Probable potassium transport system protein kup OS=Aromatoleum aromaticum (strain EbN1) GN=kup PE=3 ...	601.0	[0..6]	[622..23]
KUP_ZYMMO - Probable potassium transport system protein kup OS=Zymomonas mobilis subsp. mobilis (strain ATCC 318... KUP_ZYMMO - Probable potassium transport system protein kup OS=Zymomonas mobilis GN=kup PE=3 SV=1	598.0	[0..3]	[622..27]
KUP1_MAGSA - Probable potassium transport system protein kup 1 OS=Magnetospirillum magneticum (strain AMB-1 / ATC...	596.0	[0..7]	[622..22]
KUP_BDEBA - Probable potassium transport system protein kup OS=Bdellovibrio bacteriovorus GN=kup PE=3 SV=1 KUP_BDEBA - Probable potassium transport system protein kup OS=Bdellovibrio bacteriovorus (strain ATCC 15356 / D...	593.0	[0..3]	[622..41]
KUP_YERP3 - Low affinity potassium transport system protein kup OS=Yersinia pseudotuberculosis serotype O:1b (st... KUP_YERPS - Low affinity potassium transport system protein kup OS=Yersinia pseudotuberculosis serotype I (strai... KUP_YERPS - Low affinity potassium transport system protein kup OS=Yersinia pseudotuberculosis GN=kup PE=3 SV=1 KUP_YERPB - Low affinity potassium transport system protein kup OS=Yersinia pseudotuberculosis serotype IB (stra... KUP_YERPY - Low affinity potassium transport system protein kup OS=Yersinia pseudotuberculosis serotype O:3 (str...	592.0	[0..1]	[622..1]

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Predicted Domain #1

Region A:
Residues: [1-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTDNKQSLP AITLAAIGVV YGDIGTSPLY TLRECLSGQF GFGVERDAVF GFLSLIFWLL  60
   61 IFVVSIKYLT FVMRADNAGE GGILTLMSLA GRNTSARTTS MLVIMGLIGG SFFYGEVVIT 120
  121 PAISVMSAIE GLEIVAPQLD TWIVPLSIIV LTLLFMIQKH GTAMVGKLFA PIMLTWFLIL 180
  181 AGLGLRSIIA NPEVLHALNP MWAVHFFLEY KTVSFIALGA VVLSITGVEA LYADMGHFGK 240
  241 FPIRLAWFTV VLPSLTLNYF GQGALLLKNP EAIKNPFFLL APDWALIPLL IIAALATVIA 300
  301 SQAVISGVFS LTRQAVRLGY LSPMRIIHTS EMESGQIYIP FVNWMLYVAV VIVIVSFEHS 360
  361 SNLAAAYGIA VTGTMVLTSI LSTTVARQNW HWNKYFVALI LIAFLCVDIP LFTANLDKLL 420
  421 SGGWLPLSLG TVMFIVMTTW KSERFRLLRR MHEH

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.21
Match:	2a65A
Description:	Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	4.88630622071834	bayes_pls_golite062009
cation transmembrane transporter activity	4.32521787992483	bayes_pls_golite062009
ion transmembrane transporter activity	4.27255146158842	bayes_pls_golite062009
transporter activity	3.46503611631839	bayes_pls_golite062009
transmembrane transporter activity	3.34431027577801	bayes_pls_golite062009
substrate-specific transporter activity	3.08398439124803	bayes_pls_golite062009
active transmembrane transporter activity	2.98812190037621	bayes_pls_golite062009
amine transmembrane transporter activity	1.84089435211537	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.37015067735708	bayes_pls_golite062009
symporter activity	1.31198147603118	bayes_pls_golite062009
solute:cation symporter activity	1.31198147603118	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.20549091362469	bayes_pls_golite062009
solute:sodium symporter activity	0.868753445363102	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.716334764204393	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	0.627257208878789	bayes_pls_golite062009
organic acid transmembrane transporter activity	0.625686018130389	bayes_pls_golite062009
amino acid transmembrane transporter activity	0.455036513774109	bayes_pls_golite062009
binding	0.299468111884938	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.260067997236861	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [455-622]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNSLEAMIAS LEKSPPVRVP GTAVYMSRAI NVIPFALMHN LKHNKVLHER VILLTLRTED  60
   61 APYVHNVRRV QIEQLSPTFW RVVASYGWRE TPNVEEVFHR CGLEGLSCRM METSFFMSHE 120
  121 SLILGKRPWY LRLRGKLYLL LQRNALRAPD QFEIPPNRVI ELGTQVEI

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	3.853872
Match:	PF02705.7
Description:	No description for PF02705.7 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: