YRC Public Data Repository - Protein Structure Prediction

Protein:	IDND_ECOLI
Organism:	Escherichia coli
Length:	343 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IDND_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|157278309, gi... - gi\|42412381\|gb\|AAS15570.1\| class III alcohol dehydrogenase [Oryzias latipes], gi\|157278309\|ref\|NP_00...	308.0	[0..3]	[343..8]
gi\|238727202, gi... - gi\|77978816\|ref\|ZP_00834240.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia int...	308.0	[0..3]	[343..4]
gi\|238715026, gi... - gi\|77958654\|ref\|ZP_00822684.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia ber...	307.0	[0..3]	[343..4]
gi\|83845254, gi\|... - gi\|83944007\|ref\|ZP_00956464.1\| zinc-binding dehydrogenase [Sulfitobacter sp. EE-36], gi\|83845254\|gb\|...	307.0	[0..3]	[343..5]
gi\|40795502 - gi\|40795502\|gb\|AAR91477.1\| thermostable alcohol dehydrogenase [Geobacillus sp. M10EXG]	306.0	[0..5]	[343..1]
gi\|160861160, gi... - gi\|160875638\|ref\|YP_001554954.1\| S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydr... gi\|68542288, gi\|... - gi\|68542288\|ref\|ZP_00582021.1\| Zinc-containing alcohol dehydrogenase superfamily [Shewanella baltica... gi\|77816052, gi\|... - gi\|77816052\|ref\|ZP_00815261.1\| Zinc-containing alcohol dehydrogenase superfamily [Shewanella putrefa... gi\|153000927, gi... - gi\|153000927\|ref\|YP_001366608.1\| S-(hydroxymethyl)glutathione dehydrogenase [Shewanella baltica OS18... gi\|146863790, gi... - gi\|217973117\|ref\|YP_002357868.1\| S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydr...	305.0	[0..3]	[343..9]
gi\|88860103, gi\|... - gi\|88860103\|ref\|ZP_01134742.1\| alcohol dehydrogenase class III [Pseudoalteromonas tunicata D2], gi\|8...	305.0	[0..3]	[343..6]
SO2054 - alcohol dehydrogenase class III gi\|24347949, gi\|... - gi\|24373614\|ref\|NP_717657.1\| alcohol dehydrogenase class III [Shewanella oneidensis MR-1], gi\|243479...	305.0	[0..3]	[343..9]
gi\|88797687, gi\|... - gi\|88797687\|ref\|ZP_01113275.1\| zinc-binding dehydrogenase [Reinekea sp. MED297], gi\|88779364\|gb\|EAR1...	304.0	[0..2]	[343..5]
gi\|54308673, gi\|... - gi\|54308673\|ref\|YP_129693.1\| putative alcohol dehydrogenase class III [Photobacterium profundum SS9]...	304.0	[0..3]	[343..6]

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Predicted Domain #1

Region A:
Residues: [1-343]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVKTQSCVV AGKKTVAVTE QTIDWNNNGT LVQITRGGIC GSDLHYYQEG KVGNFMIKAP  60
   61 MVLGHEVIGK VIHSDSSELH EGQTVAINPS KPCGHCKYCI EHNENQCTDM RFFGSAMYFP 120
  121 HVDGGFTRYK MVETSQCVPY PAKADEKVMA FAEPLAVAIH AAHQAGELQG KRVFISGVGP 180
  181 IGCLIVSAVK TLGAAEIVCA DVSPRSLSLG KEMGADVLVN PQNDDMDHWK AEKGYFDVSF 240
  241 EVSGHPSSVN TCLEVTRARG VMVQVGMGGA MAEFPMMTLI GKEISLRGSF RFTSEFNTAV 300
  301 SWLANGVINP LPLLSAEYPF TDLEEALRFA GDKTQAAKVQ LVF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.69897
Match:	1e3jA
Description:	Ketose reductase (sorbitol dehydrogenase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ethanol binding	4.47659026306883	bayes_pls_golite062009
NAD or NADH binding	4.35058438816264	bayes_pls_golite062009
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	3.00103406168296	bayes_pls_golite062009
alcohol binding	2.97042200128883	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
all-trans retinal binding	2.84803957533249	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
retinoid binding	1.54383322726845	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
isoprenoid binding	1.42961392805059	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.38219425408212	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07006097264025	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.527946013169731	bayes_pls_golite062009
chaperone binding	0.522820098665177	bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity	0.382131941157781	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
binding	0.355184540089764	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.320177384202291	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.250698007650211	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: