YRC Public Data Repository - Protein Structure Prediction

Protein:	IDH_ECOLI
Organism:	Escherichia coli
Length:	416 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IDH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|209772816, gi... - pir\|\|H90829 isocitrate dehydrogenase [imported] - Escherichia coli (strain O157:H7, substrain RIMD ... gi\|254591996, gi... - gi\|254792596\|ref\|YP_003077433.1\| isocitrate dehydrogenase, specific for NADP+ [Escherichia coli O157... gi\|12514790, gi\|... - gi\|15801333\|ref\|NP_287350.1\| isocitrate dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|12514790... gi\|15830862, gi\|... - gi\|15830862\|ref\|NP_309635.1\| isocitrate dehydrogenase [Escherichia coli O157:H7], gi\|13361072\|dbj\|BA... gi\|209161150, gi... - gi\|209399750\|ref\|YP_002270054.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 ... gi\|217318692, gi... - gi\|217328265\|ref\|ZP_03444347.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 s... gi\|195938768 - gi\|195938768\|ref\|ZP_03084150.1\| isocitrate dehydrogenase [Escherichia coli O157:H7 str. EC4024] gi\|208806739, gi... - gi\|208806739\|ref\|ZP_03249076.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 s... gi\|208733096, gi... - gi\|208816448\|ref\|ZP_03257627.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 s... gi\|208822384, gi... - gi\|208822384\|ref\|ZP_03262703.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 s... gi\|168776051, gi... - gi\|187768512\|gb\|EDU32356.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ... gi\|188999974, gi... - gi\|188999974\|gb\|EDU68960.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ... gi\|168787612, gi... - gi\|189372428\|gb\|EDU90844.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ... gi\|15830862, gi\|... - gi\|15830862\|ref\|NP_309635.1\| isocitrate dehydrogenase [Escherichia coli O157:H7 str. Sakai], gi\|1336... gi\|189377227, gi... - gi\|189377227\|gb\|EDU95643.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ... gi\|188015980, gi... - gi\|188015980\|gb\|EDU54102.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ... gi\|189356331, gi... - gi\|189356331\|gb\|EDU74750.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ... gi\|189367150, gi... - gi\|189367150\|gb\|EDU85566.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ... gi\|189360164, gi... - gi\|189360164\|gb\|EDU78583.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli O157:H7 str. ...	501.0	[0..1]	[416..1]
gi\|157831249, gi... - gi\|157831249\|pdb\|1GRP\|A Chain A, Regulatory And Catalytic Mechanisms In Escherichia Coli Isocitrate ...	501.0	[0..1]	[416..1]
gi\|194711150, gi... - gi\|194735648\|ref\|YP_002114245.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp... gi\|213428086 - gi\|213428086\|ref\|ZP_03360836.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serova... gi\|213580468 - gi\|213580468\|ref\|ZP_03362294.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serova... gi\|213613159 - gi\|213613159\|ref\|ZP_03370985.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serova... gi\|16502407, gi\|... - gi\|25528244\|pir\|\|AG0647 isocitrate dehydrogenase [imported] - Salmonella enterica subsp. enterica se... gi\|29142116, gi\|... - gi\|29142116\|ref\|NP_805458.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serovar T... gi\|168239145, gi... - gi\|197288130\|gb\|EDY27517.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp. ent... gi\|205336804, gi... - gi\|205336804\|gb\|EDZ23568.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp. ent... gi\|194449522, gi... - gi\|194449522\|ref\|YP_002045240.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serov... gi\|16760113 - gi\|16760113\|ref\|NP_455730.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serovar T... gi\|213850124 - gi\|213850124\|ref\|ZP_03381022.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serova... gi\|214002199 - gi\|214002199\|ref\|ZP_03412934.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serova...	500.0	[0..1]	[416..1]
gi\|117623321, gi... - gi\|117623321\|ref\|YP_852234.1\| isocitrate dehydrogenase [Escherichia coli APEC O1], gi\|115512445\|gb\|A... gi\|194418084, gi... - gi\|83569543\|ref\|ZP_00920995.1\| COG0538: Isocitrate dehydrogenases [Shigella dysenteriae 1012], gi\|19... gi\|209911652, gi... - gi\|209918393\|ref\|YP_002292477.1\| isocitrate dehydrogenase [Escherichia coli SE11], gi\|209911652\|dbj\|... gi\|194424100, gi... - gi\|83587308\|ref\|ZP_00925936.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli 101-1], gi\|19443... gi\|170679954, gi... - gi\|170679954\|ref\|YP_001744041.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli SMS-3-5]... gi\|157155568, gi... - gi\|75190222\|ref\|ZP_00703489.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli E24377A], gi\|157... gi\|218360482, gi... - gi\|218553714\|ref\|YP_002386627.1\| isocitrate dehydrogenase [Escherichia coli IAI1], gi\|218360482\|emb\|... gi\|75209216, gi\|... - gi\|75209216\|ref\|ZP_00709463.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli B171], gi\|194429... gi\|218356682, gi... - gi\|218549141\|ref\|YP_002382932.1\| isocitrate dehydrogenase [Escherichia fergusonii ATCC 35469], gi\|21... gi\|192954977, gi... - gi\|75214683\|ref\|ZP_00713194.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli E110019], gi\|193... gi\|218426653, gi... - gi\|218689089\|ref\|YP_002397301.1\| isocitrate dehydrogenase [Escherichia coli ED1a], gi\|218426653\|emb\|... gi\|75228452, gi\|... - gi\|75228452\|ref\|ZP_00715092.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli B7A], gi\|1911683... gi\|218364787, gi... - gi\|218558018\|ref\|YP_002390931.1\| isocitrate dehydrogenase [Escherichia coli S88], gi\|218364787\|emb\|C... gi\|227886507, gi... - gi\|227886507\|ref\|ZP_04004312.1\| isocitrate dehydrogenase [Escherichia coli 83972], gi\|227836711\|gb\|E... gi\|75239634, gi\|... - gi\|75239634\|ref\|ZP_00723601.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli F11], gi\|1911730... gi\|218431707, gi... - gi\|218704610\|ref\|YP_002412129.1\| isocitrate dehydrogenase [Escherichia coli UMN026], gi\|218431707\|em... gi\|237706878, gi... - gi\|237706878\|ref\|ZP_04537359.1\| isocitrate dehydrogenase [Escherichia sp. 3_2_53FAA], gi\|226898088\|g... gi\|193066250, gi... - gi\|75255660\|ref\|ZP_00727432.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli E22], gi\|1930662... gi\|218370322, gi... - gi\|218700336\|ref\|YP_002407965.1\| isocitrate dehydrogenase [Escherichia coli IAI39], gi\|218370322\|emb... gi\|242376938, gi... - gi\|251784665\|ref\|YP_002998969.1\| hypothetical protein B21_01142 [Escherichia coli BL21], gi\|24237693... gi\|253324884, gi... - gi\|254288051\|ref\|YP_003053799.1\| isocitrate dehydrogenase [Escherichia coli BL21(DE3)], gi\|253977358... gi\|253973144, gi... - gi\|254161243\|ref\|YP_003044351.1\| isocitrate dehydrogenase [Escherichia coli B str. REL606], gi\|25397... gi\|30062683, gi\|... - gi\|30062683\|ref\|NP_836854.1\| isocitrate dehydrogenase [Shigella flexneri 2a str. 2457T], gi\|30040931... gi\|14624985 - gi\|14624985\|dbj\|BAB61874.1\| isocitrate dehydrogenase [Escherichia coli] gi\|24112555, gi\|... - gi\|24112555\|ref\|NP_707065.1\| isocitrate dehydrogenase [Shigella flexneri 2a str. 301], gi\|24051450\|g... gi\|26247386, gi\|... - gi\|26247386\|ref\|NP_753426.1\| isocitrate dehydrogenase [Escherichia coli CFT073], gi\|26107787\|gb\|AAN7... gi\|91210293, gi\|... - gi\|91210293\|ref\|YP_540279.1\| isocitrate dehydrogenase [Escherichia coli UTI89], gi\|91071867\|gb\|ABE06... gi\|110342905, gi... - gi\|110641313\|ref\|YP_669043.1\| isocitrate dehydrogenase [Escherichia coli 536], gi\|110342905\|gb\|ABG69... gi\|110805164, gi... - gi\|110805164\|ref\|YP_688684.1\| isocitrate dehydrogenase [Shigella flexneri 5 str. 8401], gi\|110614712...	500.0	[0..1]	[416..1]
gi\|205353028, gi... - gi\|205353028\|ref\|YP_002226829.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serov... gi\|206709058, gi... - gi\|207857255\|ref\|YP_002243906.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serov... gi\|238910943 - gi\|238910943\|ref\|ZP_04654780.1\| isocitrate dehydrogenase [Salmonella enterica subsp. enterica serova... gi\|198245823, gi... - gi\|198245823\|ref\|YP_002215897.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp... gi\|199602197, gi... - gi\|200389752\|ref\|ZP_03216363.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp.... gi\|194446384, gi... - gi\|194446384\|ref\|YP_002040494.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp... gi\|16419757, gi\|... - gi\|16764593\|ref\|NP_460208.1\| isocitrate dehydrogenase [Salmonella typhimurium LT2], gi\|16419757\|gb\|A... gi\|194470122, gi... - gi\|194470122\|ref\|ZP_03076106.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp.... gi\|205332631, gi... - gi\|205332631\|gb\|EDZ19395.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp. ent... gi\|205347242, gi... - gi\|205347242\|gb\|EDZ33873.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp. ent... gi\|205329724, gi... - gi\|205329724\|gb\|EDZ16488.1\| isocitrate dehydrogenase, NADP-dependent [Salmonella enterica subsp. ent...	499.0	[0..1]	[416..1]
gi\|169755399, gi... - gi\|170020471\|ref\|YP_001725425.1\| isocitrate dehydrogenase [Escherichia coli ATCC 8739], gi\|169755399... gi\|238900390, gi... - gi\|238900390\|ref\|YP_002926186.1\| e14 prophage; isocitrate dehydrogenase, specific for NADP+ [Escheri... gi\|187428445, gi... - gi\|75179242\|ref\|ZP_00699260.1\| COG0538: Isocitrate dehydrogenases [Shigella boydii BS512], gi\|187731... gi\|169888622, gi... - gi\|170080787\|ref\|YP_001730107.1\| isocitrate dehydrogenase, specific for NADP+ [Escherichia coli str.... gi\|73855172, gi\|... - gi\|74311695\|ref\|YP_310114.1\| isocitrate dehydrogenase [Shigella sonnei Ss046], gi\|73855172\|gb\|AAZ878... gi\|81245788, gi\|... - gi\|82544377\|ref\|YP_408324.1\| isocitrate dehydrogenase [Shigella boydii Sb227], gi\|81245788\|gb\|ABB664... gi\|75195317, gi\|... - gi\|75195317\|ref\|ZP_00705387.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli HS], gi\|15716066... gi\|188491528, gi... - gi\|75511656\|ref\|ZP_00734303.1\| COG0538: Isocitrate dehydrogenases [Escherichia coli 53638], gi\|18849... tr\|A0A0G3HI88\|A0... - Isocitrate dehydrogenase [NADP] OS=Escherichia coli (strain K12) GN=icd PE=3 SV=1 gi\|124499589, gi... - gi\|124529881\|ref\|ZP_01700725.1\| isocitrate dehydrogenase, NADP-dependent [Escherichia coli B], gi\|12...	499.0	[0..1]	[416..1]

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Predicted Domain #1

Region A:
Residues: [1-416]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESKVVVPAQ GKKITLQNGK LNVPENPIIP YIEGDGIGVD VTPAMLKVVD AAVEKAYKGE  60
   61 RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIREYRVAIK GPLTTPVGGG IRSLNVALRQ 120
  121 ELDLYICLRP VRYYQGTPSP VKHPELTDMV IFRENSEDIY AGIEWKADSA DAEKVIKFLR 180
  181 EEMGVKKIRF PEHCGIGIKP CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA 240
  241 FKDWGYQLAR EEFGGELIDG GPWLKVKNPN TGKEIVIKDV IADAFLQQIL LRPAEYDVIA 300
  301 CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK VNPGSIILSA 360
  361 EMMLRHMGWT EAADLIVKGM EGAINAKTVT YDFERLMDGA KLLKCSEFGD AIIENM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	143.0
Match:	1isoA
Description:	ISOCITRATE DEHYDROGENASE: STRUCTURE OF AN ENGINEERED NADP+--> NAD+ SPECIFICITY-REVERSAL MUTANT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
isocitrate dehydrogenase (NAD+) activity	5.9567768649084	bayes_pls_golite062009
isocitrate dehydrogenase activity	5.76817846591752	bayes_pls_golite062009
3-isopropylmalate dehydrogenase activity	4.43187390953534	bayes_pls_golite062009
isocitrate dehydrogenase (NADP+) activity	3.47645456015586	bayes_pls_golite062009
malate dehydrogenase activity	3.17013707624362	bayes_pls_golite062009
oxidoreductase activity	2.74237430402883	bayes_pls_golite062009
catalytic activity	2.71251959637136	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.46799258909805	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.38235863668553	bayes_pls_golite062009
binding	0.768867938429375	bayes_pls_golite062009
malic enzyme activity	0.483776792839856	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.466038297142601	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: