YRC Public Data Repository - Protein Structure Prediction

Protein:	HTPX_ECOLI
Organism:	Escherichia coli
Length:	293 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HTPX_ECOLI.

Description	E-value	Query Range	Subject Range
HTPX_ERWCT - Protease HtpX OS=Erwinia carotovora subsp. atroseptica GN=htpX PE=3 SV=1 HTPX_PECAS - Protease HtpX OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=htpX PE=3 SV=1	250.0	[0..1]	[293..1]
gi\|188013563, gi... - gi\|188013563\|gb\|EDU51685.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4113], gi\|1687526... gi\|168758592, gi... - gi\|189354623\|gb\|EDU73042.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4401], gi\|1687585... gi\|189360375, gi... - gi\|189360375\|gb\|EDU78794.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4486], gi\|1687708... gi\|188999448, gi... - gi\|188999448\|gb\|EDU68434.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4076], gi\|1687831... gi\|254793453, gi... - gi\|254793453\|ref\|YP_003078290.1\| predicted endopeptidase [Escherichia coli O157:H7 str. TW14359], gi... gi\|193066804, gi... - gi\|75254939\|ref\|ZP_00726891.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... HTPX_ECOLC - Protease HtpX OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=htpX PE=3 SV=1 gi\|237705781, gi... - gi\|237705781\|ref\|ZP_04536262.1\| heat shock protein HtpX [Escherichia sp. 3_2_53FAA], gi\|226900538\|gb... HTPX_SHISS - Protease HtpX OS=Shigella sonnei (strain Ss046) GN=htpX PE=3 SV=1 gi\|227885744, gi... - gi\|227885744\|ref\|ZP_04003549.1\| M48 family endopeptidase HtpX [Escherichia coli 83972], gi\|227837317... gi\|75208008, gi\|... - gi\|75208008\|ref\|ZP_00708426.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... gi\|75239751 - gi\|75239751\|ref\|ZP_00723714.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... HTPX_SHIDS - Protease HtpX OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=htpX PE=3 SV=1 HTPX_SHIBS - Protease HtpX OS=Shigella boydii serotype 4 (strain Sb227) GN=htpX PE=3 SV=1 HTPX_ECO57 - Protease HtpX OS=Escherichia coli O157:H7 GN=htpX PE=2 SV=1 gi\|217317954, gi... - gi\|217328607\|ref\|ZP_03444688.1\| M48B family peptidase [Escherichia coli O157:H7 str. TW14588], gi\|21... HTPX_ECOL6 - Protease HtpX OS=Escherichia coli O6 GN=htpX PE=3 SV=1 HTPX_ECO8A - Protease HtpX OS=Escherichia coli O8 (strain IAI1) GN=htpX PE=3 SV=1 HTPX_ECO45 - Protease HtpX OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=htpX PE=3 SV=1 HTPX_ECO81 - Protease HtpX OS=Escherichia coli O81 (strain ED1a) GN=htpX PE=3 SV=1 HTPX_ECO24 - Protease HtpX OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=htpX PE=3 SV=1 HTPX_ECO55 - Protease HtpX OS=Escherichia coli (strain 55989 / EAEC) GN=htpX PE=3 SV=1 HTPX_ECOHS - Protease HtpX OS=Escherichia coli O9:H4 (strain HS) GN=htpX PE=3 SV=1 HTPX_ECO7I - Protease HtpX OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=htpX PE=3 SV=1 HTPX_ECOLU - Protease HtpX OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=htpX PE=3 SV=1 HTPX_SHIB3 - Protease HtpX OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=htpX PE=3 SV=1 HTPX_ECOK1 - Protease HtpX OS=Escherichia coli O1:K1 / APEC GN=htpX PE=3 SV=1 HTPX_ECOSM - Protease HtpX OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=htpX PE=3 SV=1 gi\|124498872, gi... - gi\|124530977\|ref\|ZP_01701433.1\| HtpX domain protein [Escherichia coli B], gi\|124498872\|gb\|EAY46373.1... gi\|170769359, gi... - gi\|170769359\|ref\|ZP_02903812.1\| M48B family peptidase [Escherichia albertii TW07627], gi\|170121683\|g... gi\|188488604, gi... - gi\|188493405\|ref\|ZP_03000675.1\| M48B family peptidase HtpX [Escherichia coli 53638], gi\|188488604\|gb... gi\|208810633, gi... - gi\|208810633\|ref\|ZP_03252509.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4206], gi\|208... gi\|208731013, gi... - gi\|208816670\|ref\|ZP_03257790.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4045], gi\|208... gi\|208741454, gi... - gi\|208821331\|ref\|ZP_03261651.1\| M48B family peptidase [Escherichia coli O157:H7 str. EC4042], gi\|208... HTPX_ECO5E - Protease HtpX OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=htpX PE=3 SV=1 HTPX_ECOSE - Protease HtpX OS=Escherichia coli (strain SE11) GN=htpX PE=3 SV=1 HTPX_ECOUT - Protease HtpX OS=Escherichia coli (strain UTI89 / UPEC) GN=htpX PE=3 SV=1 HTPX_SHIFL - Protease HtpX OS=Shigella flexneri GN=htpX PE=3 SV=1 gi\|15831793, gi\|... - gi\|15831793\|ref\|NP_310566.1\| heat shock protein HtpX [Escherichia coli O157:H7 str. Sakai], gi\|13362... HTPX_ECOL5 - Protease HtpX OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=htpX PE=3 SV=1 HTPX_SHIF8 - Protease HtpX OS=Shigella flexneri serotype 5b (strain 8401) GN=htpX PE=3 SV=1 gi\|24112780, gi\|... - ref\|NP_707290.1\| heat shock protein HtpX [Shigella flexneri 2a str. 301], gb\|AAN42997.1\| heat shock... HTPX_ECOL6 - Protease HtpX OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=htpX PE=3 SV=1 gi\|209767788, gi... - pir\|\|C90946 heat shock protein HtpX [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0...	250.0	[0..1]	[293..1]
gi\|16760732 - gi\|16760732\|ref\|NP_456349.1\| heat shock protein HtpX [Salmonella enterica subsp. enterica serovar Ty... HTPX_SALDC - Protease HtpX OS=Salmonella dublin (strain CT_02021853) GN=htpX PE=3 SV=1 HTPX_SALPK - Protease HtpX OS=Salmonella paratyphi A (strain AKU_12601) GN=htpX PE=3 SV=1 HTPX_SALTY - Protease HtpX OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=htpX PE=3 SV=1 gi\|197241190, gi... - gi\|197262935\|ref\|ZP_03163009.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar S... gi\|29137137, gi\|... - gi\|29141510\|ref\|NP_804852.1\| heat shock protein HtpX [Salmonella enterica subsp. enterica serovar Ty... HTPX_SALA4 - Protease HtpX OS=Salmonella agona (strain SL483) GN=htpX PE=3 SV=1 HTPX_SALEP - Protease HtpX OS=Salmonella enteritidis PT4 (strain P125109) GN=htpX PE=3 SV=1 HTPX_SALG2 - Protease HtpX OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=htpX PE=3 SV=1 gi\|204931090, gi... - gi\|204931090\|ref\|ZP_03221916.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar J... gi\|199603491, gi... - gi\|200391046\|ref\|ZP_03217657.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar V... gi\|205342580, gi... - gi\|205342580\|gb\|EDZ29344.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Welte... gi\|195634383, gi... - gi\|195634383\|gb\|EDX52735.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Newpo... gi\|205350590, gi... - gi\|205350590\|gb\|EDZ37221.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Hadar... gi\|168241443, gi... - gi\|205339124\|gb\|EDZ25888.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Heide... HTPX_SALSV - Protease HtpX OS=Salmonella schwarzengrund (strain CVM19633) GN=htpX PE=3 SV=1 gi\|194470673, gi... - gi\|194470673\|ref\|ZP_03076657.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar K... HTPX_SALHS - Protease HtpX OS=Salmonella heidelberg (strain SL476) GN=htpX PE=3 SV=1 HTPX_SALNS - Protease HtpX OS=Salmonella newport (strain SL254) GN=htpX PE=3 SV=1 HTPX_SALCH - Protease HtpX OS=Salmonella choleraesuis GN=htpX PE=3 SV=1 HTPX_SALPC - Protease HtpX OS=Salmonella paratyphi C (strain RKS4594) GN=htpX PE=3 SV=1 HTPX_SALPA - Protease HtpX OS=Salmonella paratyphi A GN=htpX PE=3 SV=1 HTPX_SALTI - Protease HtpX OS=Salmonella typhi GN=htpX PE=3 SV=1 HTPX_SALCH - Probable protease htpX OS=Salmonella choleraesuis GN=htpX PE=3 SV=1 HTPX_SALTY - Protease HtpX OS=Salmonella typhimurium GN=htpX PE=3 SV=1 HTPX_SALAR - Protease HtpX OS=Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) GN=htpX PE=3 SV=1 HTPX_SALTY - Probable protease htpX OS=Salmonella typhimurium GN=htpX PE=3 SV=1 lcl\|NC_016856.1_... - [gene=htpX] [protein=heat shock protein HtpX] [protein_id=YP_005237790.1] [location=complement(19514... gi\|197288677, gi... - gi\|197288677\|gb\|EDY28052.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Schwa... HTPX_SALCH - Protease HtpX OS=Salmonella choleraesuis (strain SC-B67) GN=htpX PE=3 SV=1 gi\|168234256, gi... - gi\|205331764\|gb\|EDZ18528.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Kentu... HTPX_SALPA - Protease HtpX OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=htpX PE=3 SV=1 gi\|167993796, gi... - gi\|205328234\|gb\|EDZ14998.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar 4,[5]... HTPX_SALTI - Probable protease htpX OS=Salmonella typhi GN=htpX PE=3 SV=1 gi\|167553469, gi... - gi\|205322082\|gb\|EDZ09921.1\| M48B family peptidase [Salmonella enterica subsp. enterica serovar Saint...	250.0	[0..1]	[293..1]
gi\|194417239, gi... - gi\|83569085\|ref\|ZP_00920546.1\| COG0501: Zn-dependent protease with chaperone function [Shigella dyse...	250.0	[0..1]	[293..1]
gi\|25296090 - gi\|25296090\|pir\|\|G85794 heat shock protein, integral membrane protein [imported] - Escherichia coli ... gi\|15802243, gi\|... - gi\|15802243\|ref\|NP_288266.1\| heat shock protein HtpX [Escherichia coli O157:H7 EDL933], gi\|12515876\|...	249.0	[0..1]	[293..1]
gi\|254288677, gi... - gi\|254288677\|ref\|YP_003054425.1\| heat shock protein HtpX [Escherichia coli BL21(DE3)], gi\|253977984\|... gi\|83584508, gi\|... - gi\|83584508\|ref\|ZP_00923186.1\| COG0501: Zn-dependent protease with chaperone function [Escherichia c... gi\|242377550, gi... - gi\|251785277\|ref\|YP_002999581.1\| hypothetical protein B21_01788 [Escherichia coli BL21], gi\|24237755... gi\|254161889, gi... - gi\|254161889\|ref\|YP_003044997.1\| heat shock protein HtpX [Escherichia coli B str. REL606], gi\|253973...	249.0	[0..1]	[293..1]
HTPX_YERPG - Protease HtpX OS=Yersinia pestis bv. Antiqua (strain Angola) GN=htpX PE=3 SV=1 HTPX_YERP3 - Protease HtpX OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=htpX PE=3 SV=1 HTPX_YERPS - Protease HtpX OS=Yersinia pseudotuberculosis GN=htpX PE=3 SV=1 HTPX_YERPE - Protease HtpX OS=Yersinia pestis GN=htpX PE=3 SV=1 gi\|165992656, gi... - gi\|166008274\|ref\|ZP_02229172.1\| peptidase, M48 family [Yersinia pestis biovar Antiqua str. E1979001]... gi\|165925521, gi... - gi\|165925521\|ref\|ZP_02221353.1\| peptidase, M48 family [Yersinia pestis biovar Orientalis str. F19910... gi\|167048896, gi... - gi\|167401791\|ref\|ZP_02307282.1\| peptidase, M48 family [Yersinia pestis biovar Antiqua str. UG05-0454... gi\|166210679, gi... - gi\|166210679\|ref\|ZP_02236714.1\| peptidase, M48 family [Yersinia pestis biovar Antiqua str. B42003004... gi\|167426790, gi... - gi\|167426790\|ref\|ZP_02318543.1\| peptidase, M48 family [Yersinia pestis biovar Mediaevalis str. K1973... gi\|167422601, gi... - gi\|167422601\|ref\|ZP_02314354.1\| peptidase, M48 family [Yersinia pestis biovar Orientalis str. MG05-1... HTPX_YERPY - Protease HtpX OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=htpX PE=3 SV=1 gi\|167467650 - gi\|167467650\|ref\|ZP_02332354.1\| peptidase, M48 family protein [Yersinia pestis FV-1] HTPX_YERPA - Protease HtpX OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=htpX PE=3 SV=1 HTPX_YERPN - Protease HtpX OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=htpX PE=3 SV=1 gi\|45436404, gi\|... - gi\|45441543\|ref\|NP_993082.1\| heat shock protein HtpX [Yersinia pestis biovar Microtus str. 91001], g... gi\|21958684, gi\|... - gi\|22125761\|ref\|NP_669184.1\| heat shock protein HtpX [Yersinia pestis KIM], gi\|21958684\|gb\|AAM85435.... gi\|16121966, gi\|... - gi\|218928834\|ref\|YP_002346709.1\| heat shock protein HtpX [Yersinia pestis CO92], gi\|16121966\|ref\|NP_... HTPX_YERPS - Protease HtpX OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=htpX PE=3 SV=1 gi\|89103074, gi\|... - gi\|89103074\|ref\|ZP_01175669.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia pest... gi\|149290713, gi... - gi\|149366339\|ref\|ZP_01888373.1\| putative heat shock protein [Yersinia pestis CA88-4125], gi\|14929071... HTPX_YERPB - Protease HtpX OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=htpX PE=3 SV=1 gi\|229843820, gi... - gi\|229843820\|ref\|ZP_04463963.1\| predicted endopeptidase [Yersinia pestis biovar Orientalis str. Indi... HTPX_YERPP - Protease HtpX OS=Yersinia pestis (strain Pestoides F) GN=htpX PE=3 SV=1 gi\|229702425, gi... - gi\|229894670\|ref\|ZP_04509851.1\| predicted endopeptidase [Yersinia pestis Pestoides A], gi\|229702425\|... gi\|229897080, gi... - gi\|229897080\|ref\|ZP_04512236.1\| predicted endopeptidase [Yersinia pestis biovar Orientalis str. PEXU...	248.0	[0..1]	[293..1]
gi\|238724840, gi... - gi\|77975215\|ref\|ZP_00830751.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia fred...	248.0	[0..1]	[293..1]
gi\|56479890, gi\|... - gi\|56479890\|ref\|NP_707290.2\| heat shock protein HtpX [Shigella flexneri 2a str. 301], gi\|56383441\|gb... gi\|30062915, gi\|... - gi\|30062915\|ref\|NP_837086.1\| heat shock protein HtpX [Shigella flexneri 2a str. 2457T], gi\|30041164\|... gi\|195939730 - gi\|195939730\|ref\|ZP_03085112.1\| heat shock protein HtpX [Escherichia coli O157:H7 str. EC4024]	248.0	[0..2]	[293..1]
gi\|238728851, gi... - gi\|77980102\|ref\|ZP_00835517.1\| COG0501: Zn-dependent protease with chaperone function [Yersinia inte...	247.0	[0..1]	[293..1]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRIALFLLT NLAVMVVFGL VLSLTGIQSS SVQGLMIMAL LFGFGGSFVS LLMSKWMALR  60
   61 SVGGEVIEQ

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	19.744727
Match:	PF06509.2
Description:	No description for PF06509.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [70-152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRNERERWLV NTVATQARQA GIAMPQVAIY HAPDINAFAT GARRDASLVA VSTGLLQNMS  60
   61 PDEAEAVIAH EISHIANGDM VTM

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.04
Match:	1c7kA
Description:	Zinc protease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.52170890235712	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.20265930105587	bayes_pls_golite062009
metallopeptidase activity	2.46762211541241	bayes_pls_golite062009
hydrolase activity	2.3590043825345	bayes_pls_golite062009
endopeptidase activity	2.3107572739426	bayes_pls_golite062009
metalloendopeptidase activity	1.69802747425985	bayes_pls_golite062009
catalytic activity	0.843772148375291	bayes_pls_golite062009
binding	0.655247478888488	bayes_pls_golite062009
protein binding	0.273409914175328	bayes_pls_golite062009
exopeptidase activity	0.160545038651425	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [153-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLIQGVVNTF VIFISRILAQ LAAGFMGGNR DEGEESNGNP LIYFAVATVL ELVFGILASI  60
   61 ITMWFSRHRE FHADAGSAKL VGREKMIAAL QRLKTSYEPQ EATSMMALCI NGKSKSLSEL 120
  121 FMTHPPLDKR IEALRTGEYL K

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	3.508638
Match:	PF01435.9
Description:	No description for PF01435.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: