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View Structure Prediction Details

Protein: HNR_ECOLI
Organism: Escherichia coli
Length: 337 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNR_ECOLI.

Description E-value Query
Range
Subject
Range
gi|146398219, gi... - gi|88934576|ref|ZP_01140218.1| Helix-turn-helix, Fis-type [Geobacter uraniumreducens Rf4], gi|889187...
294.0 [0..6] [333..1]
gi|221565741, gi... - gi|222056452|ref|YP_002538814.1| two component, sigma54 specific, transcriptional regulator, Fis fam...
290.0 [0..6] [334..1]
gi|158320115, gi... - gi|158320115|ref|YP_001512622.1| two component, sigma54 specific, Fis family transcriptional regulat...
288.0 [0..6] [335..1]
gi|70732213, gi|... - gi|70732213|ref|YP_261969.1| sigma-54 dependent DNA-binding response regulator [Pseudomonas fluoresc...
287.0 [0..6] [336..1]
gi|39996595, gi|... - gi|39996595|ref|NP_952546.1| sigma-54 dependent DNA-binding response regulator [Geobacter sulfurredu...
286.0 [0..6] [333..1]
gi|85774842, gi|... - gi|86158331|ref|YP_465116.1| two component, sigma54 specific, Fis family transcriptional regulator [...
284.0 [0..8] [335..2]
gi|78222609, gi|... - gi|78222609|ref|YP_384356.1| two component, sigma54 specific, Fis family transcriptional regulator [...
284.0 [0..6] [335..1]
gi|45522425, gi|... - gi|91775408|ref|YP_545164.1| two component, sigma54 specific, Fis family transcriptional regulator [...
284.0 [0..3] [336..1]
gi|67980037, gi|... - gi|95930447|ref|ZP_01313183.1| two component, sigma54 specific, transcriptional regulator, Fis famil...
284.0 [0..5] [337..1]
gi|93451451, gi|... - gi|94268821|ref|ZP_01291291.1| Response regulator receiver [delta proteobacterium MLMS-1], gi|934514...
284.0 [0..8] [333..2]

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Predicted Domain #1
Region A:
Residues: [1-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQPLVGKQI LIVEDEQVFR SLLDSWFSSL GATTVLAADG VDALELLGGF TPDLMICDIA  60
   61 MPRMNGLKLL EHIRNRGDQT PVLVISATEN MADIAKALRL GVEDVLLKPV KDLNRLREMV 120
  121 FACLYPSMFN SRVEEEERLF RDWDAMVDNP AAAAKLLQEL QPPVQQVISH CRVNYRQLVA 180
  181 ADKPGLVLDI AALSENDLAF YCLDVTRAGH NGVLAALLLR ALFNGLLQEQ LAHQNQRLPE 240
  241 LGALLKQVNH LLRQANLPGQ FPLLVGYYHR ELKNLILVSA GLNATLNTGE HQVQISNGVP 300
  301 LGTLGNAYLN QLSQRCDAWQ CQIWGTGGRL RLMLSAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.09691
Match: 1ny5A
Description: Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein histidine kinase activity 2.35011582062573 bayes_pls_golite062009
two-component sensor activity 2.32303301074957 bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor 2.28838869071567 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.69240737024755 bayes_pls_golite062009
pyrophosphatase activity 1.65296291878002 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.64318297340116 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.64169398852165 bayes_pls_golite062009
two-component response regulator activity 1.45919623810582 bayes_pls_golite062009
catalytic activity 1.37148167194523 bayes_pls_golite062009
binding 1.30574971150356 bayes_pls_golite062009
ATPase activity 1.20060977637766 bayes_pls_golite062009
transporter activity 1.14815595550467 bayes_pls_golite062009
ATPase activity, coupled 1.08141765801535 bayes_pls_golite062009
transmembrane transporter activity 1.01232806016411 bayes_pls_golite062009
active transmembrane transporter activity 0.92246823619313 bayes_pls_golite062009
nucleic acid binding 0.900561861643259 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.89546790004613 bayes_pls_golite062009
primary active transmembrane transporter activity 0.89065853471483 bayes_pls_golite062009
hydrolase activity 0.875592967682638 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.8668136831732 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.86536264587818 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.86511385357843 bayes_pls_golite062009
transcription regulator activity 0.530058973650498 bayes_pls_golite062009
DNA binding 0.460315660888175 bayes_pls_golite062009
purine ribonucleotide binding 0.3056113353665 bayes_pls_golite062009
ribonucleotide binding 0.30512981340046 bayes_pls_golite062009
purine nucleotide binding 0.30259037403175 bayes_pls_golite062009
nucleotide binding 0.28998663538132 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle