YRC Public Data Repository - Protein Structure Prediction

Protein:	GUDP_ECOLI
Organism:	Escherichia coli
Length:	450 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUDP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|67668083, gi\|... - gi\|67668083\|ref\|ZP_00465278.1\| General substrate transporter:Major facilitator superfamily [Burkhold...	249.0	[0..4]	[449..1028]
gi\|78495751, gi\|... - gi\|78495751\|ref\|ZP_00847969.1\| Major facilitator superfamily MFS_1 [Rhodopseudomonas palustris BisB1...	216.0	[0..2]	[439..433]
gi\|169764102 - gi\|169764102\|ref\|XP_001727951.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83770979 - gi\|83770979\|dbj\|BAE61112.1\| unnamed protein product [Aspergillus oryzae]	214.0	[0..1]	[448..192]
gi\|60470323, gi\|... - gi\|66816473\|ref\|XP_642246.1\| sugar transporter family protein [Dictyostelium discoideum AX4], gi\|604... gi\|60470323 - gi\|60470323\|gb\|EAL68303.1\| hypothetical protein DDB0205325 [Dictyostelium discoideum]	212.0	[0..12]	[450..173]
SNF3 - Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmemb... SNF3_YEAST - High-affinity glucose transporter SNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=S...	211.0	[0..7]	[449..86]
gi\|28871682, gi\|... - gi\|28871682\|ref\|NP_794301.1\| major facilitator superfamily transporter phthalate permease [Pseudomon... tr\|Q87WJ8\|Q87WJ8... - MFS transporter, phthalate permease family OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=PSP... gi\|213966707, gi... - gi\|213966707\|ref\|ZP_03394858.1\| MFS transporter, phthalate permease family [Pseudomonas syringae pv....	209.0	[0..11]	[449..3]
gi\|115265519 - gi\|115265519\|dbj\|BAF32781.1\| MFS transporter of phthalate permease family [Pseudomonas syringae pv. ...	209.0	[0..11]	[449..3]
gi\|71555792, gi\|... - gi\|71735239\|ref\|YP_276369.1\| major facilitator superfamily transporter phthalate permease [Pseudomon...	209.0	[0..11]	[449..3]
gi\|68389434 - gi\|68389434\|ref\|XP_691920.1\| PREDICTED: similar to solute carrier family 17 (sodium-dependent inorga...	208.0	[0..16]	[441..141]

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Predicted Domain #1

Region A:
Residues: [1-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLSQAASS VEKRTNARYW IVVMLFIVTS FNYGDRATLS IAGSEMAKDI GLDPVGMGYV  60
   61 FSAFSWAYVI GQIPGGWLLD RFGSKRVYFW SIFIWSMFTL LQGFVDIFSG FGIIVALFTL 120
  121 RFLVGLAEAP SFPGNSRIVA AWFPAQERGT AVSIFNSAQY FATVIFAPIM GWLTHEVGWS 180
  181 HVFFFMGGLG IVISFIWLKV IHEPNQHPGV NKKELEYIAA GGALINMDQQ NTKVKVPFSV 240
  241 KWGQIKQLLG SRMMIGVYIG QYCINALTYF FITWFPVYLV QARGMSILKA GFVASVPAVC 300
  301 GFIGGVLGGI ISDWLMRRTG SLNIARKTPI VMGMLLSMVM VFCNYVNVEW MIIGFMALAF 360
  361 FGKGIGALGW AVMADTAPKE ISGLSGGLFN MFGNISGIVT PIAIGYIVGT TGSFNGALIY 420
  421 VGVHALIAVL SYLVLVGDIK RIELKPVAGQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.0
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glucose-6-phosphate transmembrane transporter activity	8.42101508058771	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	8.42101508058771	bayes_pls_golite062009
glycerol transmembrane transporter activity	7.11654923455995	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	6.56587510931539	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
anion transmembrane transporter activity	3.94605227012838	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	3.5078894802599	bayes_pls_golite062009
organic anion transmembrane transporter activity	3.3413526350788	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	2.33121027955345	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
phosphate transmembrane transporter activity	1.78662033436109	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.26757615356623	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: