YRC Public Data Repository - Protein Structure Prediction

Protein:	GARP_ECOLI
Organism:	Escherichia coli
Length:	444 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GARP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|67668083, gi\|... - gi\|67668083\|ref\|ZP_00465278.1\| General substrate transporter:Major facilitator superfamily [Burkhold...	249.0	[0..3]	[443..1029]
SNF3 - Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmemb... SNF3_YEAST - High-affinity glucose transporter SNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=S...	221.0	[0..5]	[444..86]
gi\|169764102 - gi\|169764102\|ref\|XP_001727951.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83770979 - gi\|83770979\|dbj\|BAE61112.1\| unnamed protein product [Aspergillus oryzae]	218.0	[0..13]	[443..208]
gi\|78495751, gi\|... - gi\|78495751\|ref\|ZP_00847969.1\| Major facilitator superfamily MFS_1 [Rhodopseudomonas palustris BisB1...	217.0	[0..5]	[435..438]
gi\|115402325, gi... - gi\|115402325\|ref\|XP_001217239.1\| hypothetical protein ATEG_08653 [Aspergillus terreus NIH2624], gi\|1...	215.0	[0..3]	[444..38]
gi\|60470323, gi\|... - gi\|66816473\|ref\|XP_642246.1\| sugar transporter family protein [Dictyostelium discoideum AX4], gi\|604... gi\|60470323 - gi\|60470323\|gb\|EAL68303.1\| hypothetical protein DDB0205325 [Dictyostelium discoideum]	213.0	[0..10]	[444..173]
gi\|49526727 - gi\|49526727\|emb\|CAG60354.1\| unnamed protein product [Candida glabrata] gi\|50289971, gi\|... - gi\|50289971\|ref\|XP_447417.1\| hypothetical protein CAGL0I03872g [Candida glabrata CBS138], gi\|4952672...	210.0	[0..18]	[444..118]
gi\|46115976, gi\|... - gi\|46115976\|ref\|XP_384006.1\| hypothetical protein FG03830.1 [Gibberella zeae PH-1], gi\|42548689\|gb\|E...	207.0	[0..7]	[444..575]
gi\|16080636, gi\|... - gi\|2636109\|emb\|CAB15600.1\| ywtG [Bacillus subtilis subsp. subtilis str. 168], gi\|16080636\|ref\|NP_391... gi\|7446721, gi\|1... - pir\|\|E70070 metabolite transport protein homolog ywtG - Bacillus subtilis, gi\|1894771\|emb\|CAB07473.1...	207.0	[0..17]	[444..7]
gi\|52005333, gi\|... - gi\|52787512\|ref\|YP_093341.1\| YwtG [Bacillus licheniformis ATCC 14580], gi\|52350014\|gb\|AAU42648.1\| Yw...	207.0	[0..11]	[440..2]

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Predicted Domain #1

Region A:
Residues: [1-444]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILDTVDEKK KGVHTRYLIL LIIFIVTAVN YADRATLSIA GTEVAKELQL SAVSMGYIFS  60
   61 AFGWAYLLMQ IPGGWLLDKF GSKKVYTYSL FFWSLFTFLQ GFVDMFPLAW AGISMFFMRF 120
  121 MLGFSEAPSF PANARIVAAW FPTKERGTAS AIFNSAQYFS LALFSPLLGW LTFAWGWEHV 180
  181 FTVMGVIGFV LTALWIKLIH NPTDHPRMSA EELKFISENG AVVDMDHKKP GSAAASGPKL 240
  241 HYIKQLLSNR MMLGVFFGQY FINTITWFFL TWFPIYLVQE KGMSILKVGL VASIPALCGF 300
  301 AGGVLGGVFS DYLIKRGLSL TLARKLPIVL GMLLASTIIL CNYTNNTTLV VMLMALAFFG 360
  361 KGFGALGWPV ISDTAPKEIV GLCGGVFNVF GNVASIVTPL VIGYLVSELH SFNAALVFVG 420
  421 CSALMAMVCY LFVVGDIKRM ELQK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.69897
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glycerol transmembrane transporter activity	7.11654923455995	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	6.56587510931539	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
anion transmembrane transporter activity	3.94605227012838	bayes_pls_golite062009
cation transmembrane transporter activity	3.88180006470231	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	2.6188895673796	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	2.6188895673796	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	2.52916479889426	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	1.6904339767429	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.02928844080554	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
phosphate transmembrane transporter activity	0.312628600969375	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: