YRC Public Data Repository - Protein Structure Prediction

Protein:	FADB_ECOLI
Organism:	Escherichia coli
Length:	729 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FADB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|83647442, gi\|... - gi\|83647442\|ref\|YP_435877.1\| multifunctional fatty acid oxidation complex subunit alpha [Hahella che...	678.0	[0..1]	[714..1]
gi\|208739696, gi... - gi\|208819573\|ref\|ZP_03259893.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H... FADB_ECO5E - Fatty acid oxidation complex subunit alpha OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=fad... gi\|217321899, gi... - gi\|217325678\|ref\|ZP_03441762.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H... gi\|189376668, gi... - gi\|189376668\|gb\|EDU95084.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H7 st... gi\|195938136 - gi\|195938136\|ref\|ZP_03083518.1\| multifunctional fatty acid oxidation complex subunit alpha [Escheric... gi\|13364250, gi\|... - gi\|15834028\|ref\|NP_312801.1\| multifunctional fatty acid oxidation complex subunit alpha [Escherichia... gi\|208725428, gi... - gi\|208805627\|ref\|ZP_03247964.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H... gi\|208813116, gi... - gi\|208813116\|ref\|ZP_03254445.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H... gi\|254595242, gi... - gi\|254795842\|ref\|YP_003080679.1\| fused 3-hydroxybutyryl-CoA epimerase and delta(3)-cis-delta(2)-tran... gi\|168763975, gi... - gi\|189365972\|gb\|EDU84388.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H7 st... gi\|168768131, gi... - gi\|189362619\|gb\|EDU81038.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H7 st... gi\|168775599, gi... - gi\|187768874\|gb\|EDU32718.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H7 st... gi\|168780749, gi... - gi\|189001484\|gb\|EDU70470.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H7 st... FADB_ECO57 - Fatty acid oxidation complex subunit alpha OS=Escherichia coli O157:H7 GN=fadB PE=3 SV=1 gi\|25291848, gi\|... - pir\|\|F91225 hypothetical protein ECs4774 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|188015432, gi... - gi\|188015432\|gb\|EDU53554.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H7 st... gi\|189359058, gi... - gi\|189359058\|gb\|EDU77477.1\| fatty oxidation complex, alpha subunit FadB [Escherichia coli O157:H7 st...	672.0	[0..1]	[729..1]
gi\|89092152, gi\|... - gi\|89092152\|ref\|ZP_01165107.1\| fatty-acid oxidation complex alpha-subunit [Oceanospirillum sp. MED92...	672.0	[0..1]	[715..1]
gi\|15804436, gi\|... - gi\|15804436\|ref\|NP_290476.1\| multifunctional fatty acid oxidation complex subunit alpha [Escherichia... gi\|25291853 - gi\|25291853\|pir\|\|D86072 hypothetical protein fadB [imported] - Escherichia coli (strain O157:H7, su...	672.0	[0..1]	[729..1]
gi\|30043119, gi\|... - gi\|30064859\|ref\|NP_839030.1\| multifunctional fatty acid oxidation complex subunit alpha [Shigella fl... gi\|56480454, gi\|... - gi\|56480454\|ref\|NP_709650.2\| multifunctional fatty acid oxidation complex subunit alpha [Shigella fl... FADB_SHIFL - Fatty acid oxidation complex subunit alpha OS=Shigella flexneri GN=fadB PE=3 SV=4 FADB_SHIF8 - Fatty acid oxidation complex subunit alpha OS=Shigella flexneri serotype 5b (strain 8401) GN=fadB PE...	671.0	[0..1]	[729..1]
gi\|145900 - gi\|145900\|gb\|AAA23750.1\| fatty acid oxidizing complex [Escherichia coli]	670.0	[0..1]	[729..1]
gi\|90437630, gi\|... - gi\|90581109\|ref\|ZP_01236908.1\| Putative fatty oxidation complex, alpha subunit [Vibrio angustum S14]...	668.0	[0..1]	[717..1]
FADB_PHOLL - Fatty acid oxidation complex subunit alpha OS=Photorhabdus luminescens subsp. laumondii (strain DSM ... FADB_PHOLL - Fatty acid oxidation complex subunit alpha OS=Photorhabdus luminescens subsp. laumondii GN=fadB PE=3...	668.0	[0..1]	[715..1]
gi\|83569320, gi\|... - gi\|83569320\|ref\|ZP_00920775.1\| COG1250: 3-hydroxyacyl-CoA dehydrogenase [Shigella dysenteriae 1012],...	666.0	[0..1]	[729..1]

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Predicted Domain #1

Region A:
Residues: [1-729]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYKGDTLYL DWLEDGIAEL VFDAPGSVNK LDTATVASLG EAIGVLEQQS DLKGLLLRSN  60
   61 KAAFIVGADI TEFLSLFLVP EEQLSQWLHF ANSVFNRLED LPVPTIAAVN GYALGGGCEC 120
  121 VLATDYRLAT PDLRIGLPET KLGIMPGFGG SVRMPRMLGA DSALEIIAAG KDVGADQALK 180
  181 IGLVDGVVKA EKLVEGAKAV LRQAINGDLD WKAKRQPKLE PLKLSKIEAT MSFTIAKGMV 240
  241 AQTAGKHYPA PITAVKTIEA AARFGREEAL NLENKSFVPL AHTNEARALV GIFLNDQYVK 300
  301 GKAKKLTKDV ETPKQAAVLG AGIMGGGIAY QSAWKGVPVV MKDINDKSLT LGMTEAAKLL 360
  361 NKQLERGKID GLKLAGVIST IHPTLDYAGF DRVDIVVEAV VENPKVKKAV LAETEQKVRQ 420
  421 DTVLASNTST IPISELANAL ERPENFCGMH FFNPVHRMPL VEIIRGEKSS DETIAKVVAW 480
  481 ASKMGKTPIV VNDCPGFFVN RVLFPYFAGF SQLLRDGADF RKIDKVMEKQ FGWPMGPAYL 540
  541 LDVVGIDTAH HAQAVMAAGF PQRMQKDYRD AIDALFDANR FGQKNGLGFW RYKEDSKGKP 600
  601 KKEEDAAVED LLAEVSQPKR DFSEEEIIAR MMIPMVNEVV RCLEEGIIAT PAEADMALVY 660
  661 GLGFPPFHGG AFRWLDTLGS AKYLDMAQQY QHLGPLYEVP EGLRNKARHN EPYYPPVEPA 720
  721 RPVGDLKTA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1wdkA
Description:	fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form I (native2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
long-chain-3-hydroxyacyl-CoA dehydrogenase activity	4.80462645980977	bayes_pls_golite062009
3-hydroxybutyryl-CoA epimerase activity	4.30714786835318	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydratase activity	4.29069790566708	bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity	4.09442487131529	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	4.03462681763369	bayes_pls_golite062009
CoA carboxylase activity	3.89913842968597	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.85567083340773	bayes_pls_golite062009
acetyl-CoA C-acyltransferase activity	3.6090947563188	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	3.4980371783229	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	3.06391460989761	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.02758902218302	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
propionyl-CoA carboxylase activity	1.20853698666984	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	1.10855899772836	bayes_pls_golite062009
transporter activity	0.793769336118517	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.788034697021177	bayes_pls_golite062009
transmembrane transporter activity	0.635891484075352	bayes_pls_golite062009
binding	0.553666136934364	bayes_pls_golite062009
retinol dehydrogenase activity	0.530688665000667	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.439912268968251	bayes_pls_golite062009
substrate-specific transporter activity	0.300373102236296	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009
signal transducer activity	0.201915860594054	bayes_pls_golite062009
molecular transducer activity	0.201915860594054	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.165260811069909	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009
ion transmembrane transporter activity	0.0257250793986203	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: