YRC Public Data Repository - Protein Structure Prediction

Protein:	EX5C_ECOLI
Organism:	Escherichia coli
Length:	1122 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EX5C_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194426379, gi... - gi\|75212545\|ref\|ZP_00712569.1\| COG1330: Exonuclease V gamma subunit [Escherichia coli B171], gi\|1944...	927.0	[0..1]	[1122..1]
gi\|193065104, gi... - gi\|75256826\|ref\|ZP_00728420.1\| COG1330: Exonuclease V gamma subunit [Escherichia coli E22], gi\|19306...	926.0	[0..1]	[1122..1]
gi\|253974651, gi... - gi\|254162750\|ref\|YP_003045858.1\| exonuclease V (RecBCD complex), gamma chain [Escherichia coli B str... gi\|253978816, gi... - gi\|254289509\|ref\|YP_003055257.1\| exonuclease V (RecBCD complex), gamma chain [Escherichia coli BL21(... gi\|75511962, gi\|... - gi\|75511962\|ref\|ZP_00734565.1\| COG1330: Exonuclease V gamma subunit [Escherichia coli 53638], gi\|188... gi\|194439865, gi... - gi\|83584779\|ref\|ZP_00923441.1\| COG1330: Exonuclease V gamma subunit [Escherichia coli 101-1], gi\|194... gi\|251786097, gi... - gi\|251786097\|ref\|YP_003000401.1\| hypothetical protein B21_02631 [Escherichia coli BL21], gi\|24237837...	926.0	[0..1]	[1122..1]
gi\|194434353, gi... - gi\|83569184\|ref\|ZP_00920642.1\| COG1330: Exonuclease V gamma subunit [Shigella dysenteriae 1012], gi\|...	926.0	[0..1]	[1122..1]
gi\|157067954, gi... - gi\|75196790\|ref\|ZP_00706860.1\| COG1330: Exonuclease V gamma subunit [Escherichia coli HS], gi\|157162...	926.0	[0..1]	[1122..1]
gi\|25289144, gi\|... - pir\|\|A85934 DNA helicase RecC [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pir... gi\|15803341, gi\|... - gi\|15803341\|ref\|NP_289374.1\| exonuclease V subunit gamma [Escherichia coli O157:H7 EDL933], gi\|12517... gi\|13363151, gi\|... - gi\|15832933\|ref\|NP_311706.1\| DNA helicase [Escherichia coli O157:H7], gi\|13363151\|dbj\|BAB37102.1\| DN... gi\|189365393, gi... - gi\|189365393\|gb\|EDU83809.1\| exodeoxyribonuclease V, gamma subunit [Escherichia coli O157:H7 str. EC4... gi\|217319423, gi... - gi\|217327056\|ref\|ZP_03443139.1\| exodeoxyribonuclease V, gamma subunit [Escherichia coli O157:H7 str.... gi\|13363151, gi\|... - gi\|15832933\|ref\|NP_311706.1\| exonuclease V subunit gamma [Escherichia coli O157:H7 str. Sakai], gi\|1...	925.0	[0..1]	[1122..1]
gi\|75215036, gi\|... - gi\|75215036\|ref\|ZP_00713496.1\| COG1330: Exonuclease V gamma subunit [Escherichia coli E110019], gi\|1...	925.0	[0..1]	[1122..1]
gi\|75228188, gi\|... - gi\|75228188\|ref\|ZP_00714850.1\| COG1330: Exonuclease V gamma subunit [Escherichia coli B7A], gi\|19116...	925.0	[0..1]	[1122..1]
gi\|91073791, gi\|... - gi\|91212217\|ref\|YP_542203.1\| exonuclease V subunit gamma [Escherichia coli UTI89], gi\|91073791\|gb\|AB... gi\|218366603, gi... - gi\|218559834\|ref\|YP_002392747.1\| exonuclease V subunit gamma [Escherichia coli S88], gi\|218366603\|em... gi\|226899557, gi... - gi\|237706517\|ref\|ZP_04536998.1\| exonuclease V subunit gamma [Escherichia sp. 3_2_53FAA], gi\|22689955... gi\|117625075, gi... - gi\|117625075\|ref\|YP_854063.1\| exonuclease V subunit gamma [Escherichia coli APEC O1], gi\|115514199\|g...	924.0	[0..1]	[1122..1]
gi\|26249251, gi\|... - gi\|26249251\|ref\|NP_755291.1\| exonuclease V subunit gamma [Escherichia coli CFT073], gi\|26109658\|gb\|A... gi\|227888385, gi... - gi\|227888385\|ref\|ZP_04006190.1\| exodeoxyribonuclease V [Escherichia coli 83972], gi\|227834654\|gb\|EEJ...	924.0	[0..1]	[1122..1]

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Predicted Domain #1

Region A:
Residues: [1-1122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRVYHSNRL DVLEALMEFI VERERLDDPF EPEMILVQST GMAQWLQMTL SQKFGIAANI  60
   61 DFPLPASFIW DMFVRVLPEI PKESAFNKQS MSWKLMTLLP QLLEREDFTL LRHYLTDDSD 120
  121 KRKLFQLSSK AADLFDQYLV YRPDWLAQWE TGHLVEGLGE AQAWQAPLWK ALVEYTHQLG 180
  181 QPRWHRANLY QRFIETLESA TTCPPGLPSR VFICGISALP PVYLQALQAL GKHIEIHLLF 240
  241 TNPCRYYWGD IKDPAYLAKL LTRQRRHSFE DRELPLFRDS ENAGQLFNSD GEQDVGNPLL 300
  301 ASWGKLGRDY IYLLSDLESS QELDAFVDVT PDNLLHNIQS DILELENRAV AGVNIEEFSR 360
  361 SDNKRPLDPL DSSITFHVCH SPQREVEVLH DRLLAMLEED PTLTPRDIIV MVADIDSYSP 420
  421 FIQAVFGSAP ADRYLPYAIS DRRARQSHPV LEAFISLLSL PDSRFVSEDV LALLDVPVLA 480
  481 ARFDITEEGL RYLRQWVNES GIRWGIDDDN VRELELPATG QHTWRFGLTR MLLGYAMESA 540
  541 QGEWQSVLPY DESSGLIAEL VGHLASLLMQ LNIWRRGLAQ ERPLEEWLPV CRDMLNAFFL 600
  601 PDAETEAAMT LIEQQWQAII AEGLGAQYGD AVPLSLLRDE LAQRLDQERI SQRFLAGPVN 660
  661 ICTLMPMRSI PFKVVCLLGM NDGVYPRQLA PLGFDLMSQK PKRGDRSRRD DDRYLFLEAL 720
  721 ISAQQKLYIS YIGRSIQDNS ERFPSVLVQE LIDYIGQSHY LPGDEALNCD ESEARVKAHL 780
  781 TCLHTRMPFD PQNYQPGERQ SYAREWLPAA SQAGKAHSEF VQPLPFTLPE TVPLETLQRF 840
  841 WAHPVRAFFQ MRLQVNFRTE DSEIPDTEPF ILEGLSRYQI NQQLLNALVE QDDAERLFRR 900
  901 FRAAGDLPYG AFGEIFWETQ CQEMQQLADR VIACRQPGQS MEIDLACNGV QITGWLPQVQ 960
  961 PDGLLRWRPS LLSVAQGMQL WLEHLVYCAS GGNGESRLFL RKDGEWRFPP LAAEQALHYL1020
 1021 SQLIEGYREG MSAPLLVLPE SGGAWLKTCY DAQNDAMLDD DSTLQKARTK FLQAYEGNMM1080
 1081 VRGEGDDIWY QRLWRQLTPE TMEAIVEQSQ RFLLPLFRFN QS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1w36C
Description:	RecBCD:DNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
exodeoxyribonuclease V activity	6.45399906372635	bayes_pls_golite062009
deoxyribonuclease activity	4.214585502776	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	4.1611108835958	bayes_pls_golite062009
exodeoxyribonuclease activity	4.15362118941033	bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity	3.87045877570028	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	3.51963098050513	bayes_pls_golite062009
exonuclease activity	3.26822223300964	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.16381244011837	bayes_pls_golite062009
pyrophosphatase activity	2.13284212711072	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.11265775498161	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.11046854230259	bayes_pls_golite062009
hydrolase activity	1.66122526893602	bayes_pls_golite062009
endonuclease activity	1.6546965422816	bayes_pls_golite062009
ATPase activity	1.53315090215319	bayes_pls_golite062009
binding	1.41264401383678	bayes_pls_golite062009
DNA-dependent ATPase activity	1.1653223755451	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
helicase activity	0.895387263223335	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.847189464648844	bayes_pls_golite062009
DNA helicase activity	0.8104901979223	bayes_pls_golite062009
four-way junction helicase activity	0.26252931460003	bayes_pls_golite062009
nucleic acid binding	0.216266069700019	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.156322124775303	bayes_pls_golite062009
ATP-dependent helicase activity	0.156322124775303	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
DNA strand annealing activity	0.103710151681167	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.0398638249772338	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: