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View Structure Prediction Details

Protein: pug-PB, pug-PD
Organism: Drosophila melanogaster
Length: 968 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pug-PB, pug-PD.

Description E-value Query
Range
Subject
Range
gi|89272471 - gi|89272471|emb|CAJ82471.1| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltet...
1434.0 [0..36] [968..1]

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Predicted Domain #1
Region A:
Residues: [1-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAQYQRFLK VLEKWPAEKS KVGSGEWTAE PAIKMSGAKI ISGTAVAKSI REELRNEVTA  60
   61 MSKQLADFVP GLRIVQVGGR EDSNVYIRMK IKAATEIGID AAHVQLPRSI TEVELLDKIN 120
  121 DLNEDPRVHG IIVQMPLDCD TPIDSHRITD AVSPEKDVDG LHTVNEGRLA IGDLGGFLPC 180
  181 TPWGCLELIR RSGVEIAGAR AVVLGRSKIV GTPAAELLKW ANATVTVCHS KTRNLEEITR 240
  241 SADILVVGIG VAEMVKGSWI KPGAVVIDCG INVKPDASKA SGSKLVGDVD YAEALQVAGH 300
  301 LTPVPGGVGP MTVAMLMKNT VRSAARFLER LAKSQWALQT LP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1diaA
Description: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [343-968]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKPQRPVPSD IVIARAQKPK DIAVLAKEIG LEAREVSLYG NKKAKISLSV LERLKDKEVG  60
   61 HYVVVAGMTP TPLGEGKTTT LMGLVQALGA HKLRNTMAAL RQPSQGPTFG IKGGAAGGGY 120
  121 AQVIPMEEFN LHLTGDIHAV SAANNLLAAQ LDTRIFHENT QKDKALYDRL VPAIKGQRKF 180
  181 SPIQLRRLQK LGITKTDPDT LTADEYGPFA RLDIDPDTIM WERVVDINDR YLRTITVGQS 240
  241 PTEKGISRET RFSISVASEI MAVLALSRSL EDMKQRLADM VVAFDKRGKP VTADDLGVTG 300
  301 ALAVLLKDAL EPNLMQSLEG TPVLVHAGPF ANIAHGCNSI IADEVGLKLV GKNGFVCTEA 360
  361 GFGSDIGMEK FCNIKCRTSG RKPNAMVLVA TVRAIKMHGG GAPVTPGAPL NKQYTEENLE 420
  421 LVQKGLPNLL QHIENGKAFG MPVVVSLNAH SADTPAEHEL VKKAALEAGA FAAVVSTHWA 480
  481 DGGAGAVQLA DAVIKACEQG NQFRLLYDLE LPLVDKMNKI ATTMYGAGKV VLSPAAEEKV 540
  541 KRLTDAGFGN LPICMSKVSG SFTGDAKIKG APKGFTLDVE DVYVSAGAGF VVAMCGEVTK 600
  601 MPGLPTRPAI YDIDLNTETG EIEGLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1fp7A
Description: Formyltetrahydrofolate synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
translation initiation factor activity 2.41232228963167 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.55478124277326 bayes_pls_golite062009
histone acetyltransferase activity 1.55478124277326 bayes_pls_golite062009
hydrolase activity 1.29060292615008 bayes_pls_golite062009
purine ribonucleotide binding 1.1110976601505 bayes_pls_golite062009
ribonucleotide binding 1.11103644113672 bayes_pls_golite062009
purine nucleotide binding 1.1086792521709 bayes_pls_golite062009
nucleotide binding 1.1060655022247 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.854899277460172 bayes_pls_golite062009
RNA helicase activity 0.81256037545135 bayes_pls_golite062009
ATP binding 0.80197288940364 bayes_pls_golite062009
adenyl ribonucleotide binding 0.770085840885632 bayes_pls_golite062009
adenyl nucleotide binding 0.751575230566049 bayes_pls_golite062009
RNA-dependent ATPase activity 0.74918137191219 bayes_pls_golite062009
structural constituent of ribosome 0.738234102557832 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.694120974355463 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.69117331267457 bayes_pls_golite062009
N-acyltransferase activity 0.581315571752634 bayes_pls_golite062009
N-acetyltransferase activity 0.487240078246257 bayes_pls_golite062009
kinase activity 0.431162005044036 bayes_pls_golite062009
ligase activity 0.417681194526243 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.347619818489809 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.250756824614616 bayes_pls_golite062009
acetyltransferase activity 0.190660928077915 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
structural molecule activity 0.0558641287316701 bayes_pls_golite062009
RNA binding 0.0261282189186349 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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