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View Structure Prediction Details

Protein: aap-1
Organism: Caenorhabditis elegans
Length: 522 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for aap-1.

Description E-value Query
Range
Subject
Range
gi|50761547 - gi|50761547|ref|XP_424759.1| PREDICTED: similar to Phosphatidylinositol 3-kinase regulatory subunit ...
240.0 [0..10] [446..323]

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Predicted Domain #1
Region A:
Residues: [1-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTTPGTPHG VTHSLMEQGW YWADADRSAV SKALSDQPDG SFIVRNASTP GDYTLSVKFA  60
   61 AQVKLLRIVV KDGKCGFNTD SLTHDSVVRL IEFHRNISLN IFNDALDVRL LYPVSVRRNS 120
  121 QNGKPFFKKG QLQQRMILSA KNDHDWRERL EMENLRAVHL AFERGAKLYD SAHQEMERAE 180
  181 SLYHALNQSV RDNEIKLGKL NNLLEAETDV VTQIQGSQTT SEMLKGAFAN NKTFVEESIR 240
  241 RINTELTSSK DKKKTLSGIL DEIAMKRSNS KTRLCKLMEL RSAVYDKMEP ALCSRMAAML 300
  301 DAGAEMINSE PTKVTQLLVD MELKWTPAQY LMCGTSKENA ANALIHARYR IAQLDKAVGL 360
  361 KREPQDGIFL IRGSSSHGDK LVLSVLHGER VSHCLIEQNE EGWGFEHSNV YLTTISDFVR 420
  421 YYSHFSLETH ADAIKTPLRT PA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 2shpA
Description: Tyrosine phosphatase; Tyrosine phoshatase shp-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.78762232945822 bayes_pls_golite062009
protein tyrosine phosphatase activity 1.56682857973533 bayes_pls_golite062009
protein binding 1.4273874265634 bayes_pls_golite062009
signal transducer activity 1.37370552536239 bayes_pls_golite062009
molecular transducer activity 1.37370552536239 bayes_pls_golite062009
insulin receptor binding 1.03645420161146 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.99961589504873 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.971261991185124 bayes_pls_golite062009
phosphatase activity 0.61426463918033 bayes_pls_golite062009
molecular adaptor activity 0.58947294551094 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.52889761132084 bayes_pls_golite062009
transmembrane receptor activity 0.38804729252204 bayes_pls_golite062009
receptor binding 0.24683439420295 bayes_pls_golite062009
receptor activity 0.22418018792939 bayes_pls_golite062009
protein binding, bridging 0.0904972759345899 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [443-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDAVTSDTSK PLRNGPGQVF TALPISRKYM EKALLTDDPT KPPESPEPRP DSWDSPSPDT  60
   61 PSSSDSRLVH PTTLPKSIPE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.221849
Match: 2ozoA
Description: No description for 2ozoA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle