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View Structure Prediction Details

Protein: adm-4
Organism: Caenorhabditis elegans
Length: 686 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for adm-4.

Description E-value Query
Range
Subject
Range
gi|14290143 - gi|14290143|gb|AAK59273.1| tumor necrosis factor-alpha converting enzyme [Cricetulus griseus]
320.0 [0..12] [684..32]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIQDRSLLI FLVLGILKSD AFNTRVKRHA PIRFQRSTRQ SVVHFEFLDQ EYVVDLEPNH  60
   61 STFHENFKVF TQDGPQIVPR DEYIGTVREP RAGRAVLTQL EENVYIGSLY FVDDTLHLEP 120
  121 SYPHQLSDDL GPVVGYFESD LDLNLDLSAM PVRNQVSFRR ANPFLKHRRA I

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [172-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AIPSDRRKDV LNVKRNRCTL KLVADYSFYS IFGKNNTGIV TKFLVNMIAR VNEIYTPINW  60
   61 DVGKEDDISG RGRFQNMGFS IKEIKVLDRP NASDSHYNSY SRIWEVERLL REF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 2i47A
Description: No description for 2i47A was found.

Predicted Domain #3
Region A:
Residues: [285-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AFAEGSKDFC LVHLVTARTF REVATLGLAY VSYKKWDETA GGICSKQETF NGRVAYINVL  60
   61 LSTSFANSEQ STYPLITKEI DIVVSHEYGH AWGATHDPTI DSDDPDVEEC SPNDQNGGKY 120
  121 LMSQYAQKGY DANNVLFSPC SRKLIRDVLI G

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.89
Match: 1r54A
Description: Crystal structure of the catalytic domain of human ADAM33
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.96061147455283 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.62698381655675 bayes_pls_golite062009
endopeptidase activity 3.84304541762504 bayes_pls_golite062009
metallopeptidase activity 3.47603569918171 bayes_pls_golite062009
metalloendopeptidase activity 2.59576616298909 bayes_pls_golite062009
hydrolase activity 2.43336263439566 bayes_pls_golite062009
receptor binding 1.66742824145997 bayes_pls_golite062009
exopeptidase activity 1.30802333637213 bayes_pls_golite062009
binding 0.889141120020878 bayes_pls_golite062009
catalytic activity 0.843772148375291 bayes_pls_golite062009
serine hydrolase activity 0.392345252967244 bayes_pls_golite062009
serine-type peptidase activity 0.373706268714699 bayes_pls_golite062009
collagen binding 0.299597363317699 bayes_pls_golite062009
serine-type endopeptidase activity 0.253666487713436 bayes_pls_golite062009
zinc ion binding 0.216547007147893 bayes_pls_golite062009
protein binding 0.170370724431219 bayes_pls_golite062009
aminopeptidase activity 0.113665386883273 bayes_pls_golite062009
transition metal ion binding 0.00744156656311112 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [436-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KWESCFQEEM TSFCGNGIVE DGEECDNGVD TDNEFNCCDK FCRLAVGAKC SPLNHICCTP  60
   61 TCQFHNSTHV CLPGDSLLCK ADAVCNGFSG ECPSAPPVRD GQECLEGGEC LNGVCLPFCE 120
  121 KMSIGKKSCI CEDLELSCRL CCRDYNGTCA PVPGHVYLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.0
Match: 2ao7A
Description: No description for 2ao7A was found.

Predicted Domain #5
Region A:
Residues: [595-686]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGVRCSKGSC RDRKCVNEVV DNVRNYFLIT FQTTGGVLEF IKTHIVVIAI IFFTLIFVGI  60
   61 YKIVKYGENF TEKVTHKTAG GCRSVFVKAD VN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle