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View Structure Prediction Details

Protein: CE13307
Organism: Caenorhabditis elegans
Length: 684 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE13307.

Description E-value Query
Range
Subject
Range
gi|67810531 - gi|67810531|gb|AAY81997.1| endothelin-converting enzyme-1a [Mus musculus]
644.0 [0..20] [683..41]

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Predicted Domain #1
Region A:
Residues: [1-684]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKKNKRKEK EKERKKAEKF SADEKTANIK DRIINCVYPV ILIILFWLLL FIGARQDEKP  60
   61 SLCESPQCIT LAFELSAYQD TSVSKCHNFY KATCGKYKHH QALDKHRDAK KKEVVKRIVR 120
  121 EFLRRNESSI TSKFEPAIRL MFGKCNKFSQ NKTYLDIFKD IEKIGPWPVL KSDWVDVMFN 180
  181 LNDYLLSLVE LGFTDFGLFK LEFRQLAFGQ FPVIAPSEQK QGNQLEKIIL EILEANGVQA 240
  241 DRQKLSKYLR EYSEFKSQLR HMSLEGTSVK YIRYNASTLS VNISALVQKM APMSTSSGLV 300
  301 RRIQSGILIT NSSSFFGKNL DAIIQQTHKR TLANYLIFHF IDAVTFDLTS GAKHSEHTLI 360
  361 DLLPRGSLQV LSQDFVDEED QGVMVEMAKD LKKHVVEMIS EGSSLDKGHL VFEEKERRKL 420
  421 IRKVQDILVV TKYPLEILNQ NFEKLNLTYS DSLHKIIQKL RRFRSEQLIE YLGGDLDPTD 480
  481 KGMWGSAHYE QATNDLIIIA PIIDGPYFDT SYPNYVNIFF MGFIISRELG RSLDSVRIRK 540
  541 DEKGHTENWL KSESLKRFDN NVKCWRKKIT GTRFLNEMLA DHVGHEASFM ALKKWEKEMN 600
  601 GTIVEKIRGY ESMTMEQIFF HLQALYFCRP PGGSTGELTA KDARQHYSTR VNEAFKNMPQ 660
  661 FAKAFGCSSN QNMNSKTKRF EEHG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 163.0
Match: 1dmtA
Description: Neutral endopeptidase (neprilysin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
bradykinin receptor binding 4.68498310889748 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.85190688399485 bayes_pls_golite062009
peptidase activity 3.61797750040144 bayes_pls_golite062009
endopeptidase activity 3.48739595085357 bayes_pls_golite062009
metallopeptidase activity 3.22757426039234 bayes_pls_golite062009
peptidyl-dipeptidase activity 3.15882456934259 bayes_pls_golite062009
hydrolase activity 2.61181165622708 bayes_pls_golite062009
metalloendopeptidase activity 2.54952091441017 bayes_pls_golite062009
angiotensin receptor activity 2.47329778652768 bayes_pls_golite062009
G-protein coupled receptor activity 2.40931483220122 bayes_pls_golite062009
transmembrane receptor activity 1.71636138555452 bayes_pls_golite062009
receptor activity 1.71573921458029 bayes_pls_golite062009
peptide binding 1.58227634414618 bayes_pls_golite062009
protein binding 1.58118182554863 bayes_pls_golite062009
binding 1.55761777216628 bayes_pls_golite062009
signal transducer activity 1.42071856700201 bayes_pls_golite062009
molecular transducer activity 1.42071856700201 bayes_pls_golite062009
viral receptor activity 1.39617252453036 bayes_pls_golite062009
epoxide hydrolase activity 1.37998417474643 bayes_pls_golite062009
ether hydrolase activity 1.18753073809881 bayes_pls_golite062009
protein complex binding 1.16270782056592 bayes_pls_golite062009
receptor binding 1.00224939479086 bayes_pls_golite062009
interleukin-6 receptor binding 0.997590082412571 bayes_pls_golite062009
integrin binding 0.93449223670512 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
peptide receptor activity, G-protein coupled 0.597899738932066 bayes_pls_golite062009
peptide receptor activity 0.574641388356132 bayes_pls_golite062009
hydrolase activity, acting on ether bonds 0.457157426475929 bayes_pls_golite062009
exopeptidase activity 0.364756038518376 bayes_pls_golite062009
aminopeptidase activity 0.21808506596674 bayes_pls_golite062009
chloride ion binding 0.13359795531295 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle