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View Structure Prediction Details

Protein: trs-1
Organism: Caenorhabditis elegans
Length: 725 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trs-1.

Description E-value Query
Range
Subject
Range
SYTC_BOVIN - Threonine--tRNA ligase, cytoplasmic OS=Bos taurus GN=TARS PE=2 SV=1
567.0 [0..15] [722..13]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLNCFRIFV HIQKPTQIFK PFYRSLSSEA SDKYHFVNGH KMSKAPTDMA PWPAFIEERI  60
   61 KLWDKLKAEY DAEIAAKESE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1vj7A
Description: Crystal structure of the bifunctional catalytic fragment of RelSeq, the RelA/SpoT homolog from Streptococcus equisimilis.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transferase activity, transferring phosphorus-containing groups 1.87905122835689 bayes_pls_golite062009
nucleic acid binding 1.54766964052089 bayes_pls_golite062009
nucleotidyltransferase activity 1.28424599869932 bayes_pls_golite062009
transferase activity 1.1355378442847 bayes_pls_golite062009
binding 1.05159429628737 bayes_pls_golite062009
DNA binding 1.00266449873436 bayes_pls_golite062009
catalytic activity 0.75232920999699 bayes_pls_golite062009
protein binding 0.117945573723438 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [81-725]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIQITLPDGK IHEGKTWRTT PFEIAERISK GLAEAAVIAK VNGAVWDLDR PFEGNAKLEL  60
   61 LKFDDDEAKQ VFWHSSAHVL GEAMERYCGG HLCYGPPIQE GFYYDMWHEN RTICPDDFPK 120
  121 IDQIVKAAVK DKQKFERLEM TKEDLLEMFK YNEFKVRIIT EKIHTPKTTV YRCGPLIDLC 180
  181 RGPHVRHTGK VKAMAITKNS SSYWEGKADA ESLQRLYGIS FPDSKQLKEW QKLQEEAAKR 240
  241 DHRKLGKEHD LFFFHQLSPG SAFWYPKGAH IYNKLVDFIR KQYRRRGFTE VITPNMYNKK 300
  301 LWETSGHWQH YSEDMFKIEV EKEEFGLKPM NCPGHCLMFG HMPHTYNELP FRFADFGVLH 360
  361 RNEMSGALTG LTRVRRFQQD DAHIFCRQDQ ISEEIKQCLD FLEYAYEKVF GFTFKLNLST 420
  421 RPEGFLGNIE TWDKAEADLT NALNASGRKW VLNPGDGAFY GPKIDITIQD ALKRNFQCAT 480
  481 IQLDFQLPNQ FDLSYFDEKG EKQRPVMIHR AVLGSVERMT AILTESYGGK WPFWLSPRQC 540
  541 KIITVHESVR DYANDVKKQI FEAGFEIEYE ENCGDTMNKQ VRKAQLAQFN FILVIGAKEK 600
  601 ENGTVNVRTR DNAVRGEVAL DKLISKFRRF ADEYVADTEK SEEWA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 151.0
Match: 1qf6A
Description: Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 7.89468709683036 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 7.89468709683036 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.88410036819636 bayes_pls_golite062009
ligase activity 6.92073480193262 bayes_pls_golite062009
threonine-tRNA ligase activity 6.47381405106149 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 2.99105702052936 bayes_pls_golite062009
serine-tRNA ligase activity 2.46505535069103 bayes_pls_golite062009
glycine-tRNA ligase activity 2.29229136935761 bayes_pls_golite062009
catalytic activity 1.99372273395202 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
histidine-tRNA ligase activity 1.72215103383322 bayes_pls_golite062009
binding 1.11470390774037 bayes_pls_golite062009
transcription regulator activity 1.0753492604686 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
nucleic acid binding 0.897558352141977 bayes_pls_golite062009
DNA binding 0.854148126675211 bayes_pls_golite062009
transcription repressor activity 0.55217603492525 bayes_pls_golite062009
transcription factor activity 0.283508546234551 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle