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View Structure Prediction Details

Protein: CE01907
Organism: Caenorhabditis elegans
Length: 658 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE01907.

Description E-value Query
Range
Subject
Range
gi|67810531 - gi|67810531|gb|AAY81997.1| endothelin-converting enzyme-1a [Mus musculus]
593.0 [0..1] [656..15]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKDQSSMLF FKDPENKNKN HVSHVEIGVP DPIEELQKLQ NRPEPCTVLA VITTLVILVL  60
   61 LIFALGALGL HDISAFKWEP KPQKALR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-658]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMLDLPCQTK ECVKYSAELL ELMDSSVNPC ENFHHHEKPD HRKAVNVVRR MLSKCAMGKT  60
   61 EEIHQVGRLS SIILPGLPFP LLNNSWTKPS DPISTSNSST TYSYPFLTKI LAHIILHNPD 120
  121 DAGFVGIKPS SDSEFSLFVV KPFSPVLTNF KFRNMYDILK RNAPESSTNG MIDLEFDRQR 180
  181 QLNDVIKLQT KLEKIEFKAD PEVVNLTEIQ RQMPIIDWKR LIDSWIPNGY AHLKEKVYGF 240
  241 NTSYYEEINA IISSTPSETI YNFLFLRFSF KFLRTEVASD LEDTCLHQLS TTIPGKIVLY 300
  301 GSEEPEALNL LNGMLHTIKD QLKRSLATLK WMDSRGIEEA QKKFNKTKTV FGFTGEDLID 360
  361 ELVGKITPES NYISTLQNVL LWQTRNMFKS VAENNVTVFL NSEVFYSVEK NEITISRALL 420
  421 HYPFMSANLP NYTNFATIAS KILPQMIHIF DERGRFYDSD GNHRNWWNTE TERYFQIIVQ 480
  481 CFDGMMQNVF GVSVSIGWNA YDSTKEPYAT LPGIQQSSDE ALFFYSMVKT MCTSDPDNVN 540
  541 EALASVPQFN SAFKCNNGTK MNPPTKCKLA S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 142.0
Match: 1dmtA
Description: Neutral endopeptidase (neprilysin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.28121680160474 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.08393764313441 bayes_pls_golite062009
metallopeptidase activity 2.43815730024908 bayes_pls_golite062009
endopeptidase activity 2.31358550762457 bayes_pls_golite062009
metalloendopeptidase activity 1.97707057855866 bayes_pls_golite062009
peptidyl-dipeptidase activity 1.67079277233897 bayes_pls_golite062009
binding 1.35913617532168 bayes_pls_golite062009
hydrolase activity 1.04791095565584 bayes_pls_golite062009
receptor binding 1.03740562606541 bayes_pls_golite062009
bradykinin receptor binding 0.901852083543819 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
exopeptidase activity 0.63315176426931 bayes_pls_golite062009
integrin binding 0.57684135424992 bayes_pls_golite062009
protein binding 0.430901196209551 bayes_pls_golite062009
transition metal ion binding 0.21514043665594 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle