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View Structure Prediction Details

Protein: prs-1
Organism: Caenorhabditis elegans
Length: 581 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for prs-1.

Description E-value Query
Range
Subject
Range
gi|157564, gi|10... - gi|1871360|gb|AAC47469.1| glutamyl-prolyl-tRNA synthetase, gi|157564|gb|AAA28594.1| transfer RNA-Glu...
463.0 [0..2] [581..1117]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTKEEITKE IEEQGAEVRR VKGDKNSTEE AKKEAIDKLL ALKLTYKEVT GQEYAAPNAR  60
   61 QSKPKKEEKP KQQPKQQEKK QDGKKQTLLG V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.154902
Match: 1nyqA
Description: Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with an analogue of threonyl adenylate
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [92-581]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTKKDDNYSE WYSEVITKAE MIEYYDVSGC YVLRPWSFAV WESIQEWFDS GIKKLGVKNC  60
   61 YFPMFVSNAA LEREKTHIAD FAPEVAWVTR AGNSEMAEPI AIRPTSETVM YPSYKKWVQS 120
  121 HRDLPIKLNQ WCNVVRWEFK HPTPFLRTRE FLWQEGHTAF ANPADAEKEV FQILDLYAGV 180
  181 YTDLLAIPVV KGRKSEKEKF AGGDFTTTVE AYVACNGRGI QGATSHHLGQ NFSKMFDISY 240
  241 EDPAKEGERA FAWQNSWGLS TRTIGAMVMI HGDDKGLVLP PRVAAVQVIV VPVGFKTENK 300
  301 QSLFDAVDKV TKDLVADGVK AEHDLRENYN AGWKFNHWEL KGVPIRFEVG PNDLAKNQVT 360
  361 AVIRHNGEKK QLSLEGLSKT VKSLLDEIHT AMYNKVLAQR DSHLKSTTCI EEFKKLLDEK 420
  421 CIILSPFCGR PDCEEEIKKA STREDGEGAQ MGAKTLCIPL DQPKQELPSK CLFPSCTYNA 480
  481 KAFALFGRSY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.0
Match: 1h4qA
Description: Prolyl-tRNA synthetase (ProRS) domain; C-terminal domain of ProRS; Prolyl-tRNA synthetase (ProRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
proline-tRNA ligase activity 7.40793503200657 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 5.35865531372193 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 5.35865531372193 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 5.34613366014959 bayes_pls_golite062009
ligase activity 4.40567333287149 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 1.82630084735103 bayes_pls_golite062009
serine-tRNA ligase activity 1.67995723068335 bayes_pls_golite062009
threonine-tRNA ligase activity 1.61348476813499 bayes_pls_golite062009
histidine-tRNA ligase activity 1.44658852946316 bayes_pls_golite062009
alanine-tRNA ligase activity 1.37855221028045 bayes_pls_golite062009
catalytic activity 1.27293510281823 bayes_pls_golite062009
lysine-tRNA ligase activity 1.2286808923607 bayes_pls_golite062009
glycine-tRNA ligase activity 1.22845858760023 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.50755166961092 bayes_pls_golite062009
binding 0.398946779962706 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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