YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC736.03c
Organism:	Schizosaccharomyces pombe
Length:	429 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC736.03c.

Description	E-value	Query Range	Subject Range
gi\|40739447, gi\|... - gi\|67540166\|ref\|XP_663857.1\| hypothetical protein AN6253.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	334.0	[0..22]	[429..6]
gi\|83769611 - gi\|83769611\|dbj\|BAE59746.1\| unnamed protein product [Aspergillus oryzae] gi\|169774561 - gi\|169774561\|ref\|XP_001821748.1\| hypothetical protein [Aspergillus oryzae RIB40]	331.0	[0..29]	[429..82]
gi\|66853273, gi\|... - gi\|71001908\|ref\|XP_755635.1\| phenylalanyl-tRNA synthetase alpha subunit (PodG) [Aspergillus fumigatu...	329.0	[0..24]	[429..81]
SYFM_MOUSE - Phenylalanine--tRNA ligase, mitochondrial OS=Mus musculus GN=Fars2 PE=1 SV=1	324.0	[0..17]	[429..51]
gi\|116003835, gi... - gi\|116003835\|ref\|NP_001070273.1\| phenylalanyl-tRNA synthetase 2, mitochondrial [Bos taurus], gi\|1153...	323.0	[0..16]	[429..45]
gi\|238881898 - gi\|238881898\|gb\|EEQ45536.1\| phenylalanyl-tRNA synthetase, mitochondrial precursor [Candida albicans ... gi\|68472589, gi\|... - gi\|68472846\|ref\|XP_719488.1\| hypothetical protein CaO19.2039 [Candida albicans SC5314], gi\|68472589\|... orf19.2039, orf1... - orf19.2039 CGDID:CAL0004392 Assembly 19, Contig19-10139 (91856, 90516) CDS, reverse complemented, tr...	321.0	[0..24]	[429..34]
gi\|49457552, gi\|... - gi\|49457552\|emb\|CAG47075.1\| FARS1 [Homo sapiens], gi\|189065522\|dbj\|BAG35361.1\| unnamed protein produ...	319.0	[0..17]	[429..51]

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Predicted Domain #1

Region A:
Residues: [1-328]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPHRVSHLS KLFSRRFPNW KRKVQTDSWS NVPEHIHSKI GRNLFQKEGH PICSLRQLLE  60
   61 QQFQKFEMNN VQKESPIVSV ETNFDSLGFP KTHVSRSKSD TYYMNNKTCL RTHTSAHQPE 120
  121 EFSRLAKEGF KKNGFLITAD VYRRDEVDSS HYPIFHQMEG ALVWNRNDTA KMKNDLKKVA 180
  181 LSPSLKSMVD DETTALETHN DMQDIYSLEE TKFVSQHLKD TLTTVIHDLV SLAPSISSGA 240
  241 EQVRYRWTYD SFPFTKPSFQ LEIDWKGKWL EILGCGVVQD RLLKGAGLNN YIGWAFGIGL 300
  301 ERLAMILYGI PDIRLFWSLD ERFSKQFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.522879
Match:	1b70A
Description:	Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phenylalanine-tRNA ligase activity	13.8919118344182	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	12.5698315343202	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	12.5698315343202	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	12.5592545638101	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
glycine-tRNA ligase activity	2.61548498770105	bayes_pls_golite062009
serine-tRNA ligase activity	2.46505535069103	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
lysine-tRNA ligase activity	1.72324031407565	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
binding	0.966824335333342	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
RNA binding	0.524959231698733	bayes_pls_golite062009
transcription regulator activity	0.375542987753806	bayes_pls_golite062009
nucleic acid binding	0.281662799812287	bayes_pls_golite062009
protein binding	0.0804954454681041	bayes_pls_golite062009
DNA binding	0.0309732052586011	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.00572514744734753	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [329-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNKISTFKPF SKYPACFKDI AFWINNDFNP NDFYEIIRDV CQDMVESVNL IDQYTAKSGK  60
   61 TSLCYRVNYR SMERSLRNEE IDKLQEKLRN RVANSLRVEL R

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.89
Match:	1b70B
Description:	Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: