YRC Public Data Repository - Protein Structure Prediction

Protein:	sec63
Organism:	Schizosaccharomyces pombe
Length:	611 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sec63.

Description	E-value	Query Range	Subject Range
gi\|39939840, gi\|... - gi\|39939840\|ref\|XP_359457.1\| hypothetical protein MGG_05320 [Magnaporthe grisea 70-15], gb\|EAA52628....	443.0	[0..1]	[602..1]
gi\|67517109, gi\|... - gi\|67517109\|ref\|XP_658438.1\| hypothetical protein AN0834.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	440.0	[0..1]	[611..1]
gi\|46124533, gi\|... - gi\|46124533\|ref\|XP_386820.1\| hypothetical protein FG06644.1 [Gibberella zeae PH-1], gi\|42554737\|gb\|E...	437.0	[0..1]	[609..1]
gi\|70996216, gi\|... - gi\|70996216\|ref\|XP_752863.1\| protein translocation complex componenet (Npl1) [Aspergillus fumigatus ... gi\|159131616 - gi\|159131616\|gb\|EDP56729.1\| protein translocation complex componenet (Npl1), putative [Aspergillus f...	415.0	[0..1]	[611..1]
gi\|85081216 - gi\|85081216\|ref\|XP_956682.1\| hypothetical protein NCU00169 [Neurospora crassa OR74A] gi\|32403284, gi\|... - gi\|32403284\|ref\|XP_322255.1\| hypothetical protein [Neurospora crassa], gi\|28917755\|gb\|EAA27446.1\| hy...	414.0	[0..1]	[596..1]
gi\|169767430 - gi\|169767430\|ref\|XP_001818186.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|238484297, gi... - gi\|238484297\|ref\|XP_002373387.1\| protein translocation complex component (Npl1), putative [Aspergill... gi\|83766041 - gi\|83766041\|dbj\|BAE56184.1\| unnamed protein product [Aspergillus oryzae]	407.0	[0..1]	[611..1]
gi\|115492629, gi... - gi\|115492629\|ref\|XP_001210942.1\| conserved hypothetical protein [Aspergillus terreus NIH2624], gi\|11...	405.0	[0..1]	[611..1]
gi\|119186481, gi... - gi\|90302633\|gb\|EAS32264.1\| hypothetical protein CIMG_03288 [Coccidioides immitis RS], gi\|119186481\|r...	397.0	[0..1]	[611..1]
gi\|4045 - gi\|4045\|emb\|CAA34424.1\| unnamed protein product [Saccharomyces cerevisiae]	380.0	[0..1]	[608..1]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEYKYDEQ GIFFPVFLLV GTSCCVLPLT YSTILGPSAS KEKKNVRDPF QKYRPKDLKV  60
   61 QRKSIFRLRY IFLILGWLAI GFLSYKIANS RLKL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [95-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIWDPYEILG IAKGTSVDDV RRHYKRLSIK FHPDKVRNMV NTTREEVEKH YIEITNAYRA  60
   61 LTDDKTRENY ALYGTPDVPQ HISVGIALPK WISESENSIY ILGFYGLVFG IVLPYAVGKW 120
  121 WYG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.09691
Match:	1xblA
Description:	NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
signal recognition particle binding	3.28103883404258	bayes_pls_golite062009
ribonucleoprotein binding	2.20695097776982	bayes_pls_golite062009
protein binding	2.0077819170005	bayes_pls_golite062009
binding	1.75184008862922	bayes_pls_golite062009
transporter activity	1.29863098651348	bayes_pls_golite062009
Hsp70 protein binding	1.13087926351787	bayes_pls_golite062009
protein transporter activity	0.939490372372376	bayes_pls_golite062009
unfolded protein binding	0.91241047562027	bayes_pls_golite062009
substrate-specific transporter activity	0.812144232432417	bayes_pls_golite062009
heat shock protein binding	0.796066295738949	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [218-611]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRTYTRDHVH VDTVDEWFPK METSLTLDEL LSLFASSKEL TSLVPNEKNP KEYILKLLFD  60
   61 HLNRKKTNNF NTHQILSQSD VVLNALLSVA TAFGFANPVD NVLKLWQHIV QAIPLDAPFP 120
  121 LLQLPHLLME DVKNLSIRNI SSIPQFLSLS EEQTKDYLPN YSKNQLKEMR EIANGIPRIS 180
  181 VVAAKVLVDD DEYITVGAIA NLILDLKCSY GTEVVPEVST DGTETATKKD EEDAEKYHQS 240
  241 KDVVLGDVET LPYAWAPYFT QHHKTAWWIY VVDPRQNRVI VPPFSITDIP KTLRTFRIPF 300
  301 QVPPVAGTFS FQLHIMSNSY VGEDVISNLT MIVKDTSVLQ EQLQEEAVSD LEDNSDIDES 360
  361 ANAGKDFSDD ENIGSDEEDE SEYDPMDTDT SDGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.221849
Match:	2q0zX
Description:	No description for 2q0zX was found.

Predicted functions:

Term	Confidence	Notes
transporter activity	2.46466249895824	bayes_pls_golite062009
voltage-gated cation channel activity	2.40264381204753	bayes_pls_golite062009
substrate-specific transporter activity	2.37642404692102	bayes_pls_golite062009
transmembrane transporter activity	2.37262306131842	bayes_pls_golite062009
potassium channel activity	2.35561670403632	bayes_pls_golite062009
voltage-gated potassium channel activity	2.33426249687556	bayes_pls_golite062009
voltage-gated ion channel activity	2.33102664959792	bayes_pls_golite062009
substrate-specific channel activity	2.32502571419352	bayes_pls_golite062009
voltage-gated channel activity	2.32465304131102	bayes_pls_golite062009
passive transmembrane transporter activity	2.3181005726144	bayes_pls_golite062009
channel activity	2.3181005726144	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.31677709260544	bayes_pls_golite062009
cation channel activity	2.30081429233977	bayes_pls_golite062009
ion transmembrane transporter activity	2.28077016868353	bayes_pls_golite062009
ion channel activity	2.2553711462771	bayes_pls_golite062009
cation transmembrane transporter activity	2.23522391314947	bayes_pls_golite062009
ATPase activity, coupled	2.2162185402774	bayes_pls_golite062009
gated channel activity	2.16810998541959	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.15379228421204	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.00003070639929	bayes_pls_golite062009
ATPase activity	1.94063929259701	bayes_pls_golite062009
pyrophosphatase activity	1.93031967085303	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.91231918357992	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.90999409453671	bayes_pls_golite062009
protein binding	1.90127097529706	bayes_pls_golite062009
inward rectifier potassium channel activity	1.86598930407084	bayes_pls_golite062009
ligand-gated channel activity	1.81486809950722	bayes_pls_golite062009
ligand-gated ion channel activity	1.81486809950722	bayes_pls_golite062009
binding	1.77589663168522	bayes_pls_golite062009
cytoskeletal protein binding	0.56566273004515	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.223800319644873	bayes_pls_golite062009
ATP-dependent helicase activity	0.223800319644873	bayes_pls_golite062009
helicase activity	0.166899434976303	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.0561411188724552	bayes_pls_golite062009
RNA-dependent ATPase activity	0.0447036496272264	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: