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View Structure Prediction Details

Protein: prp2
Organism: Schizosaccharomyces pombe
Length: 517 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for prp2.

Description E-value Query
Range
Subject
Range
gi|73976783 - gi|73976783|ref|XP_857420.1| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...
221.0 [0..161] [514..56]
gi|76689281 - gi|76689281|ref|XP_881384.1| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...
219.0 [0..161] [514..56]
gi|48734702 - gi|48734702|gb|AAH71591.1| PABPC4 protein [Homo sapiens]
218.0 [0..161] [514..56]
gi|55959639, gi|... - gi|66267552|gb|AAH94755.1| PABPC4 protein [Homo sapiens], gi|55962217|emb|CAI12298.1| poly(A) bindin...
gi|114555673 - gi|114555673|ref|XP_001170937.1| PREDICTED: poly A binding protein, cytoplasmic 4 isoform 1 [Pan tro...
217.0 [0..161] [514..56]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLSSRLSSG SSRIPKRHRD YRDEEPRRER GSGGIGREDP RGHYGSERPR RRRRDESDFR  60
   61 RHRESRERSY REDERPRRER RYDDYEPRSL RYSSVGRSRS PPPSRERSVR S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [112-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEQELEQLRD VTPINQWKRK RSLWDIKPPG YELVTADQAK MSGVFPLPGA PRAAVTDPEK  60
   61 LLEFARSAEG SIIAPPPPLQ P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [193-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GASRQARRLV VTGIPNEFVE DAFVSFIEDL FISTTYHKPE TKHFSSVNVC KEENFAILEV  60
   61 ATPEDATFLW GLQSESYSND VFLKFQRIQN YIVPQITPEV SQKRSDDYAK NDVLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.522879
Match: 1fxlA
Description: Hu antigen D (Hud)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [308-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDKIYISNL PLNLGEDQVV ELLKPFGDLL SFQLIKNIAD GSSKGFCFCE FKNPSDAEVA  60
   61 ISGLDGKDTY GNKLHAQFAC VGLNQAMIDK SNGMAILTEL AKASSQSIPT RVLQLHNLIT 120
  121 GDEIMDVQEY EDIYESVKTQ FSNYGPLIDI KIPRSIGTRN SGLGTGKVFV RYSDIRSAEV 180
  181 AMEEMKGCKF NDRTIVIAFY GEDCYKANAW 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.154902
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.425042944899091 bayes_pls_golite062009
transporter activity 0.417047632648771 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
cytoskeletal protein binding 0.288834004308736 bayes_pls_golite062009
transmembrane transporter activity 0.288804044686487 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00171911393626201 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle