YRC Public Data Repository - Protein Structure Prediction

Protein:	ths1
Organism:	Schizosaccharomyces pombe
Length:	703 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ths1.

Description	E-value	Query Range	Subject Range
SYT_METCA - Threonyl-tRNA synthetase OS=Methylococcus capsulatus GN=thrS PE=3 SV=1 SYT_METCA - Threonine--tRNA ligase OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=thrS ...	527.0	[0..48]	[689..1]
SYT_BURS3 - Threonine--tRNA ligase OS=Burkholderia sp. (strain 383) GN=thrS PE=3 SV=1 SYT_BURL3 - Threonine--tRNA ligase OS=Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 3...	526.0	[0..48]	[691..1]
gi\|94310105, gi\|... - gi\|94310105\|ref\|YP_583315.1\| threonyl-tRNA synthetase [Ralstonia metallidurans CH34], gi\|93353957\|gb...	525.0	[0..46]	[690..27]
gi\|254245609, gi... - gi\|254245609\|ref\|ZP_04938930.1\| Threonyl-tRNA synthetase, class IIa [Burkholderia cenocepacia PC184]... gi\|162218055, gi... - gi\|67656296\|ref\|ZP_00453679.1\| Threonyl-tRNA synthetase, class IIa [Burkholderia cenocepacia AU 1054... gi\|162227933, gi... - gi\|67668173\|ref\|ZP_00465361.1\| Threonyl-tRNA synthetase, class IIa [Burkholderia cenocepacia HI2424]...	524.0	[0..48]	[691..1]
SYT_BURVG - Threonine--tRNA ligase OS=Burkholderia vietnamiensis (strain G4 / LMG 22486) GN=thrS PE=3 SV=1	523.0	[0..48]	[691..1]
SYT_METFK - Threonine--tRNA ligase OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=thrS PE...	522.0	[0..48]	[694..1]
SYT_BURCM - Threonine--tRNA ligase OS=Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) GN=thrS PE=3 SV=1	522.0	[0..48]	[691..1]
gi\|197241161, gi... - gi\|197262906\|ref\|ZP_03162980.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serova... SYT_SALTY - Threonine--tRNA ligase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=thrS PE=3 ... SYT_SALHS - Threonine--tRNA ligase OS=Salmonella heidelberg (strain SL476) GN=thrS PE=3 SV=1 SYT_SALTY - Threonyl-tRNA synthetase OS=Salmonella typhimurium GN=thrS PE=3 SV=1 gi\|168244449, gi... - gi\|205336802\|gb\|EDZ23566.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar He... gi\|205329759, gi... - gi\|205329759\|gb\|EDZ16523.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar 4,... lcl\|NC_016856.1_... - [gene=thrS] [protein=threonyl-tRNA synthetase] [protein_id=YP_005237194.1] [location=1422178..142410... SYT_SALTY - Threonine--tRNA ligase OS=Salmonella typhimurium GN=thrS PE=3 SV=1	520.0	[0..48]	[701..1]
SYT_SALTI - Threonyl-tRNA synthetase OS=Salmonella typhi GN=thrS PE=3 SV=1 gi\|199602680, gi... - gi\|200390235\|ref\|ZP_03216846.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serova... SYT_SALA4 - Threonine--tRNA ligase OS=Salmonella agona (strain SL483) GN=thrS PE=3 SV=1 SYT_SALSV - Threonine--tRNA ligase OS=Salmonella schwarzengrund (strain CVM19633) GN=thrS PE=3 SV=1 gi\|205341550, gi... - gi\|205341550\|gb\|EDZ28314.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar We... gi\|213852224 - gi\|213852224\|ref\|ZP_03381756.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serova... gi\|213426331 - gi\|213426331\|ref\|ZP_03359081.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serova... gi\|213423451 - gi\|213423451\|ref\|ZP_03356434.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serova... gi\|204927743, gi... - gi\|204927743\|ref\|ZP_03218944.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serova... gi\|168239001, gi... - gi\|197288252\|gb\|EDY27637.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sc... SYT_SALTI - Threonine--tRNA ligase OS=Salmonella typhi GN=thrS PE=3 SV=1 gi\|167552305, gi... - gi\|205323017\|gb\|EDZ10856.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sa... gi\|29141677, gi\|... - gi\|29141677\|ref\|NP_805019.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar T... gi\|16760562 - gi\|16760562\|ref\|NP_456179.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar T... gi\|238910851 - gi\|238910851\|ref\|ZP_04654688.1\| threonyl-tRNA synthetase [Salmonella enterica subsp. enterica serova...	520.0	[0..48]	[701..1]
SYT_SHIDS - Threonine--tRNA ligase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=thrS PE=3 SV=1	520.0	[0..48]	[699..1]

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Predicted Domain #1

Region A:
Residues: [1-703]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAAVKGVQ ASLDNLSLEI PFIQHRLDLF DKLQKEYKES LATKPREEID ITLPDGKVIK  60
   61 GTSWETTPIS IAASISKGLA DRVTVAIVNG EPWDLTRPLE ASCTLKLCDF NDPEGKRVFW 120
  121 HSSAHILGEA TELSFHCHLC IGPPTDEGFF YEMGIDNGRV ITNDDYSSIE SYAKQAIKQK 180
  181 QPFERLVISK EGLLEMFRYN KYKQYIIQTK IPDGASTTVY RCGPLIDLCT GPHVPHTGRI 240
  241 KSFAVTKNSS SYFLGDAKND SLQRVYGISF PDNKQMQEYK TFLAEAAKRD HRKIGRDQEL 300
  301 FFFNEISPGS CFFLPHGARI YNTLLKYMRY QYSKRGYQEV ITPNMYNVNL WKTSGHWNNY 360
  361 SENMFSFDIE KEKYALKPMN CPGHCVMFKS RDRSYRDLPW RVADFGVLHR NEFSGALSGL 420
  421 TRVRRFQQDD AHIFCTPDQV RSEIEGCFDF LKEVYGTFGF TFHLELSTRP EEKYLGDLAT 480
  481 WDKAEAQLKA ALDASGYKWE LNAGDGAFYG PKIDITVFDA LKRQHQCATI QLDFQLPERF 540
  541 QLEFHAPASA EEAKESGNNN KYTRPVMVHR AILGSLERMI AILTEHYAGK WPFWMSPRQV 600
  601 CIIPVSAAAY NYADKVHNIL SEADIFVDTD KSDNTLPKKI RNAQLAQYNF IFVVGAEEES 660
  661 TNSVNVRNRD DPKKQSKGST VAVEEVVKKL LKLKESKSLI NDL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	148.0
Match:	1qf6A
Description:	Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.89468709683036	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.89468709683036	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.88410036819636	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
threonine-tRNA ligase activity	6.47381405106149	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	3.22631630581238	bayes_pls_golite062009
serine-tRNA ligase activity	2.46505535069103	bayes_pls_golite062009
glycine-tRNA ligase activity	2.29229136935761	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
lysine-tRNA ligase activity	1.72324031407565	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
binding	1.11470390774037	bayes_pls_golite062009
transcription regulator activity	1.0753492604686	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
nucleic acid binding	0.897558352141977	bayes_pls_golite062009
DNA binding	0.854148126675211	bayes_pls_golite062009
RNA binding	0.576453255038334	bayes_pls_golite062009
transcription repressor activity	0.55217603492525	bayes_pls_golite062009
transcription factor activity	0.283508546234551	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.00572514744734753	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: