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View Structure Prediction Details

Protein: psm1
Organism: Schizosaccharomyces pombe
Length: 1233 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for psm1.

Description E-value Query
Range
Subject
Range
gi|94369992 - gi|94369992|ref|XP_979429.1| PREDICTED: similar to SMC4 structural maintenance of chromosomes 4-like...
319.0 [0..4] [953..214]
gi|50549059, gi|... - gi|50549059|ref|XP_502000.1| YALI0C19129p [Yarrowia lipolytica], gi|49647867|emb|CAG82320.1| unnamed...
gi|49647867 - gi|49647867|emb|CAG82320.1| YALI0C19129p [Yarrowia lipolytica]
304.0 [0..4] [1209..318]
ENSCJAT00000011708 - null
SMC1A - structural maintenance of chromosomes 1A
gi|168278535 - gi|168278535|dbj|BAG11147.1| structural maintenance of chromosomes protein 1A [synthetic construct]
301.0 [0..1] [1217..1]
gi|149758007 - gi|149758007|ref|XP_001495236.1| PREDICTED: similar to olfactory receptor, family 5, subfamily AT, m...
SMC1A_BOVIN - Structural maintenance of chromosomes protein 1A OS=Bos taurus GN=SMC1A PE=1 SV=1
301.0 [0..1] [1217..1]
gi|74007448 - gi|74007448|ref|XP_538049.2| PREDICTED: similar to Structural maintenance of chromosome 1-like 1 pro...
301.0 [0..1] [1217..63]
gi|88175825, gi|... - gi|88175825|gb|EAQ83293.1| hypothetical protein CHGG_09697 [Chaetomium globosum CBS 148.51], gi|1162...
301.0 [0..4] [1209..233]
SMC1A_RAT - Structural maintenance of chromosomes protein 1A OS=Rattus norvegicus GN=Smc1a PE=1 SV=1
301.0 [0..1] [1217..1]
gi|46110056, gi|... - gi|46110056|ref|XP_382086.1| hypothetical protein FG01910.1 [Gibberella zeae PH-1], gi|42545825|gb|E...
300.0 [0..1] [1223..1]

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Predicted Domain #1
Region A:
Residues: [1-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRLLRLEVE NFKSYRGHQI IGPFEDFTSI IGPNGAGKSN LMDAISFVLG VKSSHLRSTN  60
   61 VKELIYRGKI LQRDNTDFTD SSNPTTAYVK LMYELDNGEQ REYKRAITPS GATEYKIDEE 120
  121 IVTFSEYCGS LQKENILVRA RNFLVFQGDV ETIASQSPLE LSKLVEQISG SLEYKSEYDK 180
  181 SKDEQDKAVN LSAHSFNKKR GINAELRQYQ EQKTEAERYQ SQKEKRDSAQ LVYLLWKLFH 240
  241 LEKSISSNMA EVTRLKADSI QLIERRDENT KEIEKLKEKE GSIRRNLLAF DRKVRKQEKL 300
  301 IASKRPELIS IAEKALESKS NLRKIQRKAA EIEKDYSDQA STLQVLENQL TSLSAAEKEF 360
  361 LKDMQEKEQL KGLRLLPED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.30103
Match: 1w1wA
Description: Sc Smc1hd:Scc1-C complex, ATPgS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
motor activity 2.79327761685782 bayes_pls_golite062009
microtubule motor activity 2.74365461017633 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.16381244011837 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
bubble DNA binding 2.11656807287934 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.11265775498161 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.11046854230259 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
1.75135117904448 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
hydrolase activity 1.66122526893602 bayes_pls_golite062009
ATPase activity 1.53315090215319 bayes_pls_golite062009
RNA helicase activity 1.42791449104435 bayes_pls_golite062009
nucleic acid binding 1.41477043612798 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
RNA-dependent ATPase activity 1.39335733374328 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.36724390116598 bayes_pls_golite062009
protein-DNA loading ATPase activity 1.29640539057136 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
purine ribonucleotide binding 1.21658213854831 bayes_pls_golite062009
ribonucleotide binding 1.21652144153182 bayes_pls_golite062009
purine nucleotide binding 1.21571071905795 bayes_pls_golite062009
nucleotide binding 1.20347573865566 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
DNA clamp loader activity 1.12431517057397 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
DNA binding 1.11699929651302 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.989226939888218 bayes_pls_golite062009
tubulin binding 0.979946830272106 bayes_pls_golite062009
microtubule binding 0.907162506177187 bayes_pls_golite062009
recombinase activity 0.88721523495679 bayes_pls_golite062009
actin binding 0.883285269827407 bayes_pls_golite062009
RNA binding 0.715902454627085 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
kinetochore binding 0.534490088080411 bayes_pls_golite062009
guanyl nucleotide binding 0.388587892299301 bayes_pls_golite062009
guanyl ribonucleotide binding 0.372638007722845 bayes_pls_golite062009
GTP binding 0.364508542344128 bayes_pls_golite062009
centromeric DNA binding 0.322818640526369 bayes_pls_golite062009
mismatched DNA binding 0.31144582840038 bayes_pls_golite062009
GTPase activity 0.234351968078991 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
dynein binding 0.150959629961177 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
transcription factor activity 0.0434163635422169 bayes_pls_golite062009
microfilament motor activity 0.0313060889304495 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [380-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEEYEGLRSE ADKLNSNLLF KLQTLNRNIK VTSQSKDSLT SIVGDLESKI KSLHESVSSL  60
   61 DT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [442-686]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERADLLAKIN EKIESLELEK HDQQKKRLTY SELFHKTQEL NEELQSCLQK ILEASADRNE  60
   61 SKQDAKKREA LYALKRIYPE VKGRIIDLCT PTQKKYESAI AAALGKNFDA IVVETQAVAK 120
  121 ECIDYIKEQR IGIMTFFPMD TIAASPVNQK FRGTHKGARL AIDVLNFESE YERVMISAVG 180
  181 NTLICDSMTV ARDLSYNKRL NAKTVTLEGT VIHKTGLITG GSSNNRSAKH WDDHDFDLLT 240
  241 QTKDR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.85
Match: 1gxlA
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.91859588671053 bayes_pls_golite062009
structure-specific DNA binding 1.23709457794394 bayes_pls_golite062009
nucleic acid binding 1.16063754070957 bayes_pls_golite062009
DNA binding 1.10832034923143 bayes_pls_golite062009
protein binding 1.02696508439754 bayes_pls_golite062009
DNA secondary structure binding 1.02239440262162 bayes_pls_golite062009
double-stranded DNA binding 0.999818859536395 bayes_pls_golite062009
protein heterodimerization activity 0.558475595998159 bayes_pls_golite062009
catalytic activity 0.265320175609019 bayes_pls_golite062009
protein dimerization activity 0.108132520107784 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [687-996]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMHQIGEIEY QKSSCVITES DTVKLHSLES EISLLKDKYT VVSRSVEDKK KEIGHYESLI  60
   61 KEKQPHLSEL EMELRNFVKS RDELQIQVEK VEEKIFSGFC KRIGISDIHT YDEIHRTFTQ 120
  121 SFTQKQLEFT KQKSLLENRI SFEKQRVSDT RLRLERMHKF IEKDQESIDN YEQNREALES 180
  181 EVATAEAELE LLKEDFASEN SKTEKILLAA SEKKLVGKRL VSELTKLSGN ITLLESEIDR 240
  241 YVSEWHAILR KCKLEDIDVP LREGSLTSIP IDDVSNSGDI TMGEEPSEPV INFEKFGVEV 300
  301 DYDELDEELR 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.05
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [997-1059]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDGSESMASV LQEKLREYSE ELDQMSPNLR AIERLETVET RLAKLDEEFA AARKAAKNAK  60
   61 ERF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1060-1233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAVKQKRLQK FQAAFSHISE QIDPIYKELT KSPAFPLGGT AYLTLDDLDE PYLGGIKFHA  60
   61 MPPMKRFRDM DQLSGGEKTM AALALLFAIH SYQPSPFFVL DEIDAALDQT NVTKIANYIR 120
  121 QHASSGFQFV VISLKNQLFS KSEALVGIYR DQQENSSRTL SINVRDYFFL ILKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1xewY
Description: Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle