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View Structure Prediction Details

Protein: rfc1
Organism: Schizosaccharomyces pombe
Length: 934 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rfc1.

Description E-value Query
Range
Subject
Range
gi|109499686, gi... - gi|109500605|ref|XP_001078203.1| PREDICTED: similar to Activator 1 140 kDa subunit (Replication fact...
358.0 [0..1] [908..160]
gi|89348478, gi|... - gi|89362683|ref|ZP_01200487.1| Peptidase M41, FtsH [Xanthobacter autotrophicus Py2], gi|89348478|gb|...
356.0 [0..330] [837..116]
gi|114315948, gi... - gi|114327774|ref|YP_744931.1| cell division protein ftsH [Granulibacter bethesdensis CGDNIH1], gi|11...
355.0 [0..327] [813..114]
gi|77381002, gi|... - gi|77456999|ref|YP_346504.1| membrane protease FtsH catalytic subunit [Pseudomonas fluorescens Pf0-1...
354.0 [0..329] [802..112]
gi|114706805, gi... - gi|114706805|ref|ZP_01439705.1| metalloprotease (cell division protein) FtsH [Fulvimarina pelagi HTC...
353.0 [0..321] [811..108]
gi|170729313, gi... - gi|170729313|ref|YP_001774746.1| cell division protein [Xylella fastidiosa M12], gi|167964106|gb|ACA...
gi|71275933, gi|... - gi|71275933|ref|ZP_00652216.1| Peptidase M41, FtsH [Xylella fastidiosa Dixon], gi|71163310|gb|EAO130...
gi|71730229, gi|... - gi|71900019|ref|ZP_00682164.1| Peptidase M41, FtsH [Xylella fastidiosa Ann-1], gi|71730229|gb|EAO323...
351.0 [0..326] [803..120]
gi|9104871, gi|1... - gi|9104871|gb|AAF82906.1|AE003863_8 cell division protein [Xylella fastidiosa 9a5c], gi|15836698|ref...
gi|11278955 - pir||C82849 cell division protein XF0093 [imported] - Xylella fastidiosa (strain 9a5c)
351.0 [0..326] [803..120]
gi|28198007, gi|... - gi|28198007|ref|NP_778321.1| cell division protein [Xylella fastidiosa Temecula1], gi|28056067|gb|AA...
gi|71899229, gi|... - gi|71899229|ref|ZP_00681391.1| Peptidase M41, FtsH [Xylella fastidiosa Ann-1], gi|71730962|gb|EAO330...
gi|182630743, gi... - gi|182680633|ref|YP_001828793.1| ATP-dependent metalloprotease FtsH [Xylella fastidiosa M23], gi|182...
351.0 [0..326] [802..120]
gi|21107929, gi|... - gi|21242481|ref|NP_642063.1| cell division protein [Xanthomonas axonopodis pv. citri str. 306], gi|2...
351.0 [0..326] [803..120]
gi|58582572, gi|... - gi|58582572|ref|YP_201588.1| cell division protein [Xanthomonas oryzae pv. oryzae KACC10331], gi|584...
350.0 [0..326] [803..120]

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Predicted Domain #1
Region A:
Residues: [1-606]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSDIRSFF GGGNAQKKPK VSPTPTSPKP KRSLKKKRIV LSDDEDGTIE NSKVPASKSK  60
   61 VQKRNESEDI SHSLPSIVHE DDKLVGSDGV STTPDEYFEQ QSTRSRSKPR IISNKETTTS 120
  121 KDVVHPVKTE NFANDLDTTS DSKPVVHQTR ATRKPAQPKA EKSTTSKSKS HTTTATTHTS 180
  181 RSSKSKGLPR FSDEVSQALK NVPLIDVDSM GVMAPGTFYE RAATTQTPGS KPVPEGNSDC 240
  241 LSGISFVITG ILETLTRQEA TDLIKQYGGK VTGAPSVRTD FILLGENAGP RKVETIKQHK 300
  301 IPAINEDGLF YLITHLPASG GTGAAAQAAQ QKKEQEEKKI LETVARMDDS NKKESQPSQI 360
  361 WTSKYAPTSL KDICGNKGVV QKLQKWLQDY HKNRKSNFNK PGPDGLGLYK AVLLSGPPGI 420
  421 GKTTAAHLVA KLEGYDVLEL NASDTRSKRL LDEQLFGVTD SQSLAGYFGT KANPVDMAKS 480
  481 RLVLIMDEID GMSSGDRGGV GQLNMIIKKS MIPIICICND RAHPKLRPLD RTTFDLRFRR 540
  541 PDANSMRSRI MSIAYREGLK LSPQAVDQLV QGTQSDMRQI INLLSTYKLS CSEMTPQNSQ 600
  601 AVIKNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1ksfX
Description: N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 6.51495346697904 bayes_pls_golite062009
protein-DNA loading ATPase activity 6.40748863504898 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
mismatched DNA binding 2.51625633651862 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
binding 2.05253348982328 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
1.85506769032946 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
guanine/thymine mispair binding 1.69026972999845 bayes_pls_golite062009
DNA insertion or deletion binding 1.68890613599528 bayes_pls_golite062009
nucleic acid binding 1.49633029954726 bayes_pls_golite062009
microtubule motor activity 1.30090199952739 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
motor activity 1.03253378953548 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transcription regulator activity 0.748437190903548 bayes_pls_golite062009
single base insertion or deletion binding 0.629563765934841 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
double-strand/single-strand DNA junction binding 0.0136229525922795 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [607-700]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKHIVMKPWD ICSRYLHGGM FHPSSKSTIN DKLELYFNDH EFSYLMVQEN YLNTTPDRIR  60
   61 QEPPKMSHLK HLELISSAAN SFSDSDLVDS MIHG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 1iqpA
Description: Replication factor C
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [701-850]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQQHWSLMPT HALMSCVRPA SFVAGSGSRQ IRFTNWLGNN SKTNKLYRML REIQVHMRLK  60
   61 VSANKLDLRQ HYIPILYESL PVKLSTGHSD VVPEIIELMD EYYLNREDFD SITELVLPAD 120
  121 AGEKLMKTIP TAAKSAFTRK YNSSSHPIAF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.0
Match: 1sxjA
Description: Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [851-934]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGSSDVLPMK GSAQREVPDV EDAIEAEDEM LEEASDSEAA NEEDIDLSKD KFISVPKKPK  60
   61 KRTKAKAEAS SSSSTSRRSR KKTA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle