YRC Public Data Repository - Protein Structure Prediction

Protein:	ade2
Organism:	Schizosaccharomyces pombe
Length:	434 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ade2.

Description	E-value	Query Range	Subject Range
gi\|124120889, gi... - gi\|153803578\|ref\|ZP_01958164.1\| adenylosuccinate synthetase [Vibrio cholerae MZO-3], gi\|124120889\|gb... gi\|153214885, gi... - gi\|153214885\|ref\|ZP_01949683.1\| adenylosuccinate synthetase [Vibrio cholerae 1587], gi\|124115044\|gb\|... gi\|229341262, gi... - gi\|229521668\|ref\|ZP_04411086.1\| adenylosuccinate synthetase [Vibrio cholerae TM 11079-80], gi\|229341... PURA_VIBC3 - Adenylosuccinate synthetase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 ... gi\|229513526, gi... - gi\|229513526\|ref\|ZP_04402990.1\| adenylosuccinate synthetase [Vibrio cholerae TMA 21], gi\|229349403\|g... gi\|229335100, gi... - gi\|229527468\|ref\|ZP_04416860.1\| adenylosuccinate synthetase [Vibrio cholerae 12129(1)], gi\|229335100... gi\|229338163, gi... - gi\|229524582\|ref\|ZP_04413987.1\| adenylosuccinate synthetase [Vibrio cholerae bv. albensis VL426], gi... tr\|D7HFN4\|D7HFN4... - Adenylosuccinate synthetase OS=Vibrio cholerae GN=purA PE=3 SV=1, Adenylosuccinate synthetase OS=Vib... gi\|254292171, gi... - gi\|254292171\|ref\|ZP_04962941.1\| adenylosuccinate synthetase [Vibrio cholerae AM-19226], gi\|197750475... gi\|148873500, gi... - gi\|153831022\|ref\|ZP_01983689.1\| adenylosuccinate synthetase [Vibrio cholerae 623-39], gi\|148873500\|g... gi\|153825123, gi... - gi\|153825123\|ref\|ZP_01977790.1\| adenylosuccinate synthetase [Vibrio cholerae MZO-2], gi\|149741269\|gb...	697.0	[0..14]	[433..2]
PURA_VIBCH - Adenylosuccinate synthetase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)... gi\|254846847, gi... - gi\|75828746\|ref\|ZP_00758091.1\| COG0104: Adenylosuccinate synthase [Vibrio cholerae MO10], gi\|2548511... PURA_VIBCM - Adenylosuccinate synthetase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=purA PE=3 SV=1 gi\|121728998, gi... - gi\|75814700\|ref\|ZP_00745258.1\| COG0104: Adenylosuccinate synthase [Vibrio cholerae V52], gi\|12172899... gi\|229507346, gi... - gi\|229507346\|ref\|ZP_04396851.1\| adenylosuccinate synthetase [Vibrio cholerae BX 330286], gi\|22935485... gi\|229509731, gi... - gi\|229509731\|ref\|ZP_04399212.1\| adenylosuccinate synthetase [Vibrio cholerae B33], gi\|229353205\|gb\|E... gi\|229345918, gi... - gi\|229516855\|ref\|ZP_04406301.1\| adenylosuccinate synthetase [Vibrio cholerae RC9], gi\|229345918\|gb\|E... gi\|229606852, gi... - gi\|229606852\|ref\|YP_002877500.1\| adenylosuccinate synthetase [Vibrio cholerae MJ-1236], gi\|229369507... gi\|124118192, gi... - gi\|153223466\|ref\|ZP_01953889.1\| adenylosuccinate synthetase [Vibrio cholerae MAK 757], gi\|124118192\|... gi\|153820226, gi... - gi\|153820226\|ref\|ZP_01972893.1\| adenylosuccinate synthetase [Vibrio cholerae NCTC 8457], gi\|12650922... PURA_VIBCH - Adenylosuccinate synthetase OS=Vibrio cholerae GN=purA PE=3 SV=3	697.0	[0..14]	[433..2]
PURA_STRP3 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) GN... PURA_STRPQ - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M3 (strain SSI-1) GN=purA PE=3 SV=1 PURA_STRP3 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M3 GN=purA PE=3 SV=1	694.0	[0..14]	[434..1]
PURA_STRPM - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M28 GN=purA PE=3 SV=1 PURA_STRPM - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M28 (strain MGAS6180) GN=purA PE=3 SV... PURA_STRPD - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M2 (strain MGAS10270) GN=purA PE=3 SV...	692.0	[0..14]	[434..1]
PURA_STRT1 - Adenylosuccinate synthetase OS=Streptococcus thermophilus (strain CNRZ 1066) GN=purA PE=3 SV=1 PURA_STRT2 - Adenylosuccinate synthetase OS=Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) GN=purA ... gi\|55737896, gi\|... - gb\|AAV63453.1\| adenylosuccinate synthetase [Streptococcus thermophilus CNRZ1066], gb\|AAV61538.1\| ad...	692.0	[0..14]	[434..1]
PURA_STRP1 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M1 GN=purA PE=3 SV=1 gi\|13621455, gi\|... - gi\|15674367\|ref\|NP_268541.1\| adenylosuccinate synthetase [Streptococcus pyogenes M1 GAS], gi\|1362145... PURA_STRPY - (Q9A1P8) Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)	692.0	[0..14]	[434..1]
PURA_STRTD - Adenylosuccinate synthetase OS=Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) GN=purA PE=3...	692.0	[0..14]	[434..1]
gi\|148985359, gi... - gi\|148985359\|ref\|ZP_01818564.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP3-BS71], gi\|... PURA_STRPN - Adenylosuccinate synthetase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=... gi\|149023457, gi... - gi\|149023457\|ref\|ZP_01836046.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP23-BS72], gi... gi\|149010879, gi... - gi\|149010879\|ref\|ZP_01832184.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP19-BS75], gi... PURA_STRP2 - Adenylosuccinate synthetase OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) GN=purA ... gi\|147761735, gi... - gi\|149006820\|ref\|ZP_01830506.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP18-BS74], gi... gi\|149004077, gi... - gi\|149004077\|ref\|ZP_01828882.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP14-BS69], gi... gi\|148998956, gi... - gi\|148998956\|ref\|ZP_01826390.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP11-BS70], gi... gi\|148995216, gi... - gi\|148995216\|ref\|ZP_01824051.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP9-BS68], gi\|... gi\|147926201, gi... - gi\|148987737\|ref\|ZP_01819200.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP6-BS73], gi\|... PURA_STRPJ - Adenylosuccinate synthetase OS=Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) GN=purA P... gi\|168495077, gi... - gi\|183575063\|gb\|EDT95591.1\| adenylosuccinate synthetase [Streptococcus pneumoniae CDC3059-06], gi\|16... PURA_STRR6 - Adenylosuccinate synthetase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=purA PE=3 SV=1 PURA_STRPN - Adenylosuccinate synthetase OS=Streptococcus pneumoniae GN=purA PE=1 SV=1	691.0	[0..14]	[434..1]
PURA_STRP8 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M18 GN=purA PE=3 SV=1 PURA_STRP8 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=purA PE=3 SV... PURA_STRP6 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M6 GN=purA PE=3 SV=1 PURA_STRP6 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) ...	690.0	[0..14]	[434..1]

Back

Predicted Domain #1

Region A:
Residues: [1-434]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVRETGVN VSNDGITVVL GSQWGDEGKG KLVDILCDNV DVCARCQGGN NAGHTIVANG  60
   61 VTYDFHILPS GLVNPKCQNL IGSGVVVYLP AFFSELEKLE QKGLKCRDRI FISDRAHLVF 120
  121 DYHQRADALN EAELGKQSIG TTGKGIGPAY STKATRSGIR VHHLYHWAEF EARYRKNVAD 180
  181 LQKRYGAFEY DVEAELIRYK ELAQRLKPFV IDAVAFMYEA LQSKKRILVE GANALMLDLD 240
  241 FGTYPFVTSS NTTVGGVCTG LGVPPQRIAN SIGVVKAYTT RVGAGPFPTE QLNEIGDHLQ 300
  301 SVGREVGVTT GRKRRCGWLD LVVVKYSTMI NGYTSLNLTK LDILDALDEI KVAVAYIING 360
  361 KRIETFPADL DSLEEAEIVY ETFPGWKVPT TGITHWDQMP ENAKKYIEFI EKFVGVPITF 420
  421 IGVGPGRDEM LVKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1kjxA
Description:	Adenylosuccinate synthetase, PurA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	1.24165037431695	bayes_pls_golite062009
purine ribonucleotide binding	1.1110976601505	bayes_pls_golite062009
ribonucleotide binding	1.11103644113672	bayes_pls_golite062009
purine nucleotide binding	1.1086792521709	bayes_pls_golite062009
nucleotide binding	1.1060655022247	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ATP binding	0.80197288940364	bayes_pls_golite062009
adenyl ribonucleotide binding	0.770085840885632	bayes_pls_golite062009
adenyl nucleotide binding	0.751575230566049	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
kinase activity	0.431162005044036	bayes_pls_golite062009
structural constituent of ribosome	0.396187998943318	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.277694966071518	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.250756824614616	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.126821629333317	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: