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View Structure Prediction Details

Protein: nak1
Organism: Schizosaccharomyces pombe
Length: 652 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nak1.

Description E-value Query
Range
Subject
Range
gi|60649736, gi|... - gi|71896311|ref|NP_001025540.1| MAP/microtubule affinity-regulating kinase 2 [Xenopus (Silurana) tro...
376.0 [0..2] [623..56]
gi|27694575 - gi|27694575|gb|AAH43730.1| Mark2-prov protein [Xenopus laevis]
375.0 [0..2] [623..49]
gi|74196782, gi|... - gi|74196782|dbj|BAE43121.1| unnamed protein product [Mus musculus], gi|122937357|ref|NP_001073859.1|...
359.0 [0..2] [627..12]
gi|73983768 - gi|73983768|ref|XP_540890.2| PREDICTED: similar to Serine/threonine-protein kinase MARK2 (MAP/microt...
356.0 [0..2] [627..65]
gi|9845487, gi|1... - ref|NP_059672.1| MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens], gi|1749794|...
355.0 [0..2] [627..12]

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Predicted Domain #1
Region A:
Residues: [1-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENNTASSPY TKLELVGRGS YGAVYRGICN LTKETVAIKI LNLDTDEDEV SDIQKEVAVL  60
   61 SELKQSDVEN IIKYHGSYLV GTNLWIIMDY CHGGSVRTLM EAGPISEPCI SLILRETLQA 120
  121 LKFIHHAGII HRDIKAANIL VSMSGNVKLC DFGVAAELNI NRRKRITFIG TPYWMAPEVI 180
  181 RDGQEYNVMA DIWSLGITAY EIATGSPPHA KEDPFRAVYL IAHTAPPRLN GNFSALLKEF 240
  241 IASCLQDVPQ RRLDSSELLK SKFIKQYSRM SISELTNVVK RYDTWQAAGG IPQTLLLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 2j51A
Description: No description for 2j51A was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
actin binding 2.91722352767433 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
actin filament binding 1.75933904320288 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
tubulin binding 1.13686658158825 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 0.926083992524179 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of muscle 0.767275562047313 bayes_pls_golite062009
microtubule binding 0.734274677384472 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
myosin binding 0.259936573810332 bayes_pls_golite062009
transporter activity 0.187543377461637 bayes_pls_golite062009
protein complex binding 0.132247221889251 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane transporter activity 0.0413380592707298 bayes_pls_golite062009
actin-dependent ATPase activity 0.0339299940546054 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 0.01826424351081 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [299-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEADDGSDPD QETSDTAASD DGWEFGTIKQ GQSNVSSITG TSTSTTTAAT SSTTVTGTVI  60
   61 PKSSTVHEPP SSNDSHPLLQ LFKDSKISDD DSPSNAEGAS TEDSKGEVSY SQIELPSLDS 120
  121 SNLSSKKSTI QSKHTKQAED YDLFVGRTRS NSKTSSDQSI KRPLPRVVQR QKTSLGKRGI 180
  181 SMSPMKPGLR MPSSFDLQSR SISMGAFEQL STPLEAPAHK HSAVL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [524-652]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPLEVNRSIS IPPPKSISPS ILHKPSLESA SSTPKISSCS STPKPFNSKL RAHLPPLSIG  60
   61 SPAVQPLAND NYDSLGVRGL NMELFNDYPG NMHNIKSVLS LEIDIVLGEM DACLKSLECN 120
  121 LLNRKAYNE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle