YRC Public Data Repository - Protein Structure Prediction

Protein:	hsk1
Organism:	Schizosaccharomyces pombe
Length:	507 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hsk1.

Description	E-value	Query Range	Subject Range
HOG1_ASPFU - Mitogen-activated protein kinase hog1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 10... HOG1_ASPFU - Mitogen-activated protein kinase hog1 OS=Aspergillus fumigatus GN=hog1 PE=1 SV=1 gi\|159131418 - gi\|159131418\|gb\|EDP56531.1\| MAP kinase SakA [Aspergillus fumigatus A1163]	221.0	[0..56]	[476..8]
HOG1_DEBHA - Mitogen-activated protein kinase HOG1 - Debaryomyces hansenii (Yeast) (Torulaspora hansenii) gi\|50423265, gi\|... - gi\|50423265\|ref\|XP_460213.1\| DEHA-HOG1 [Debaryomyces hansenii CBS767], gi\|49655881\|emb\|CAG88486.1\| D...	221.0	[0..48]	[502..3]
HOG1_EURHE - Mitogen-activated protein kinase hog1 OS=Eurotium herbariorum GN=hog1 PE=3 SV=1	220.0	[0..57]	[476..9]
HOG1_CANAL - Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP kinase HOG1) - Candida albicans (Yeast)	220.0	[0..46]	[507..1]
HOG1_CANAL - Mitogen-activated protein kinase HOG1 OS=Candida albicans GN=HOG1 PE=1 SV=2 HOG1_CANAL - Mitogen-activated protein kinase HOG1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HOG1 PE... gi\|238882126 - gi\|238882126\|gb\|EEQ45764.1\| mitogen-activated protein kinase HOG1 [Candida albicans WO-1]	220.0	[0..46]	[507..1]
gi\|151941278 - gi\|151941278\|gb\|EDN59656.1\| MAP kinase kinase (MEK) [Saccharomyces cerevisiae YJM789] HOG1_YEAST - Mitogen-activated protein kinase HOG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HO... HOG1 - Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; media... gi\|190406146 - gi\|190406146\|gb\|EDV09413.1\| MAP kinase [Saccharomyces cerevisiae RM11-1a] gi\|207343070 - gi\|207343070\|gb\|EDZ70646.1\| YLR113Wp-like protein [Saccharomyces cerevisiae AWRI1631]	220.0	[0..50]	[477..5]
HOG1_MAGO7 - Mitogen-activated protein kinase HOG1 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 895... HOG1_MAGGR - Mitogen-activated protein kinase HOG1 OS=Magnaporthe grisea GN=HOG1 PE=3 SV=1	219.0	[0..56]	[484..8]
HOG1_BEABA - Mitogen-activated protein kinase HOG1 OS=Beauveria bassiana GN=HOG1 PE=3 SV=1 gi\|45826465\|gb\|A... - mitogen-activated protein kinase [Cordyceps bassiana]	217.0	[0..56]	[479..8]
HOG1_GLOLA - Mitogen-activated protein kinase HOG1 OS=Glomerella lagenarium GN=HOG1 PE=3 SV=1 HOG1_COLOR - Mitogen-activated protein kinase HOG1 OS=Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS ...	217.0	[0..56]	[476..8]
HOG1_YARLI - Mitogen-activated protein kinase HOG1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HOG1 PE=3 ... HOG1_YARLI - Mitogen-activated protein kinase HOG1 OS=Yarrowia lipolytica GN=HOG1 PE=3 SV=1	216.0	[0..56]	[476..8]

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Predicted Domain #1

Region A:
Residues: [1-507]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAHITLSP KVTHEQQTDI DSECEITEVD DENVNENKSQ EMIQDIPARD REEIENITRT  60
   61 FVELQENYRL IEKIGEGTFS SVYKAEDLHY GRYINDWDIQ SEVLKESSFG KEKIPVNEDS 120
  121 RKPKYVAIKK IYATSSPARI YNELEILYLL RGSSVIAPLI TALRNEDQVL VVLPYYEHTD 180
  181 FRQYYSTFSY RDMSIYFRCL FQAMQQTQTL GIIHRDIKPS NFLFDVRTKH GVLVDFGLAE 240
  241 RYDGRQQSHS CRCTNSNAAE LAHDFSIAQE TSLGYIKNDT RPSKRANRAG TRGFRAPEVL 300
  301 FKCSSQSPKV DIWSAGVILL SFLTKRFPMF NSKDDVDALM EIACIFGKSE MRQCAALHGC 360
  361 TFETNVSTLT EKRVNFRKLI LWASCGSASI YKEKLRHKPS QEERLCLDFL EKCLELDCNK 420
  421 RISAEEALDH DFLYLDNLAY EKKDDDTAFD NSFGETSFEK DEDLTAKHLS HILDFKEQEE 480
  481 TDEPTSLSKR KRSIDEILPN DALQDGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.0
Match:	1cm8A
Description:	MAP kinase p38-gamma
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
structural molecule activity	2.32133082120229	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.68012041942855	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.47162554695064	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
MAP kinase kinase activity	1.42275431028856	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	1.4045088027491	bayes_pls_golite062009
transforming growth factor beta receptor activity	1.4045088027491	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
actin binding	1.33479685165255	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.2662335835562	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription repressor activity	1.14496167267281	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
SMAD binding	1.02108562119195	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.99838484913572	bayes_pls_golite062009
transcription activator activity	0.997272622653026	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
transmembrane receptor activity	0.913893847407112	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
receptor activity	0.775180603313375	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.666159109886349	bayes_pls_golite062009
activin binding	0.664317770352101	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
insulin receptor substrate binding	0.57617745233877	bayes_pls_golite062009
activin receptor activity	0.558143200755109	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.401250804041384	bayes_pls_golite062009
structural constituent of muscle	0.399773397398032	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
structure-specific DNA binding	0.318153468064373	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
RNA binding	0.245748631571068	bayes_pls_golite062009
actin filament binding	0.2403700250846	bayes_pls_golite062009
transporter activity	0.187543377461637	bayes_pls_golite062009
growth factor binding	0.153144089598532	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.149958560815481	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.149958560815481	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.14842991990838	bayes_pls_golite062009
protein kinase C activity	0.0795689006739899	bayes_pls_golite062009
transmembrane transporter activity	0.0413380592707298	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: