YRC Public Data Repository - Protein Structure Prediction

Protein:	cdc7
Organism:	Schizosaccharomyces pombe
Length:	1062 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cdc7.

Description	E-value	Query Range	Subject Range
gi\|39944178, gi\|... - gi\|39944178\|ref\|XP_361626.1\| hypothetical protein MG04100.4 [Magnaporthe grisea 70-15], gb\|EAA50341....	1037.0	[0..6]	[1045..56]
gi\|16944338, gi\|... - gi\|32412696\|ref\|XP_326828.1\| hypothetical protein ( (AL451017) related to septation (sepH) gene [Neu... gi\|85102922 - gi\|85102922\|ref\|XP_961421.1\| hypothetical protein NCU01335 [Neurospora crassa OR74A]	1028.0	[0..6]	[1030..52]
gi\|114192924, gi... - gi\|115398283\|ref\|XP_001214733.1\| hypothetical protein ATEG_05555 [Aspergillus terreus NIH2624], gi\|1...	963.0	[0..10]	[1029..81]
gi\|46137731, gi\|... - gi\|46137731\|ref\|XP_390557.1\| hypothetical protein FG10381.1 [Gibberella zeae PH-1], gi\|42546440\|gb\|E...	945.0	[0..9]	[1029..56]
gi\|49094122, gi\|... - gi\|67528374\|ref\|XP_661989.1\| hypothetical protein AN4385.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	940.0	[0..40]	[1029..61]
gi\|83769269 - gi\|83769269\|dbj\|BAE59406.1\| unnamed protein product [Aspergillus oryzae] gi\|169773879 - gi\|169773879\|ref\|XP_001821408.1\| hypothetical protein [Aspergillus oryzae RIB40]	922.0	[0..6]	[1029..57]
gi\|88183255, gi\|... - gi\|88183255\|gb\|EAQ90723.1\| hypothetical protein CHGG_02658 [Chaetomium globosum CBS 148.51], gi\|1162...	842.0	[0..115]	[989..114]
gi\|6531993 - gi\|6531993\|gb\|AAF15541.1\| septation [Aspergillus nidulans]	819.0	[0..273]	[1029..402]
gi\|159124934 - gi\|159124934\|gb\|EDP50051.1\| serine-threonine kinase SepH [Aspergillus fumigatus A1163] gi\|70994748, gi\|... - gi\|70994748\|ref\|XP_752151.1\| serine-threonine kinase SepH [Aspergillus fumigatus Af293], gi\|66849785...	792.0	[0..259]	[1029..476]
gi\|46095877, gi\|... - gi\|71004404\|ref\|XP_756868.1\| hypothetical protein UM00721.1 [Ustilago maydis 521], ref\|XP_398336.1\| ...	761.0	[0..281]	[1049..674]

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Predicted Domain #1

Region A:
Residues: [1-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNIQASSIT LGDCLGKGAF GAVYRGLNIK NGETVAVKKV KLSKMLKSDL SVIKMEIDLL  60
   61 KNLDHPNIVK YRGSYQTNDS LCIILEYCEN GSLRSICKNF GKIPENLVAL YTFQVLQGLL 120
  121 YLHNQGVIHR DIKGANILTT KDGTIKLADF GVATKINALE DHSVVGSPYW MAPEVIELVG 180
  181 ATTASDIWSV GCTVIELLDG NPPYYDLDPT SALFRMVKDE HPPLPSNISS AAKSFLMQCF 240
  241 QKDPNLRIKT RKLLKHPWVI MNQTSSKFSD AIDEVQKYNE RVKESTLTAI IEPTSNRINP 300
  301 TLHSGRQSSY HMPESPKTPI AESPDHDNWD NEFQGTLKIS DDVLKKSEHF MDFCSNFKGK 360
  361 NNSSSITSSP SKSRHAFNSD QISESN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.522879
Match:	1o6lA
Description:	Pkb kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cyclin-dependent protein kinase activity	4.62392503670521	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
phosphoinositide 3-kinase binding	2.79505438761262	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
cation transmembrane transporter activity	1.93176092222748	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
ion transmembrane transporter activity	1.90354666768303	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.71452519680794	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
gamma-tubulin binding	1.28511591054866	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.28428643482914	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.27184436658773	bayes_pls_golite062009
insulin receptor activity	1.22442673174261	bayes_pls_golite062009
cytoskeletal protein binding	1.22172815474021	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription repressor activity	1.14496167267281	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
transcription activator activity	0.997272622653026	bayes_pls_golite062009
PTB domain binding	0.9900774724568	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.872782211382796	bayes_pls_golite062009
insulin binding	0.614254468447749	bayes_pls_golite062009
transporter activity	0.595111702412257	bayes_pls_golite062009
tubulin binding	0.525721160726465	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
actin binding	0.456340967230669	bayes_pls_golite062009
kinase binding	0.443916188551908	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
transmembrane transporter activity	0.41384976209545	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.401250804041384	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
telethonin binding	0.386946764759301	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
protein kinase binding	0.285611963740145	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
structure-specific DNA binding	0.267404531445803	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
cation channel activity	0.245400615103891	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
microtubule binding	0.191960933574742	bayes_pls_golite062009
protein complex binding	0.132247221889251	bayes_pls_golite062009
substrate-specific transporter activity	0.0922946791401962	bayes_pls_golite062009
MAP kinase activity	0.08504542461349	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0556163711947139	bayes_pls_golite062009
transmembrane receptor activity	0.00652065412910241	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [387-1062]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNASPLSTP LKAQFDPSKP ALNRSIDHQK TPQHKRYLST EFKENIPDGI EKFVETPRDS  60
   61 EFTDIFPTSS IKVQGLRKET GLGTLVLNKC YGSWNNEENE DGEESDIFDS IETNLENLDI 120
  121 ENNIALDKRT HLASLLSSLL GSLRDKNIGS KDTTVSQIAS ILSEDLSLKR EIIQAHGILP 180
  181 LLETLREIKT PDVQLLLLKL INTVAFDDHT TLQKVCFAGG LPLMLSFSNR EHSFEFRYES 240
  241 AIFIQQMYRT SALTLQMFLS SNGLNSLLLF IKEDYGTNRD FVFVGVEGIW KLLRQQDYIP 300
  301 KNDICTMVVN DSLEPLTKAM LKALATDDDS SRMSLTRICE ILLALSQADN YVKESLLCES 360
  361 ALRRILRILL YLPHSDMAIT LQFFKQLSMV PSSLSLLRKV HIIPLLTHIL GDSKIEKGRK 420
  421 EIRSEALAAL FNVCKLDKKS QEEAVISGAI PLLQEVIIKD RLFKEFALPI LLALPQAGPV 480
  481 SRIYLWQNKC LDFFLSLLSD LNWQSAVFDT IASWLQFELR EVQRVLAEKR NVQLVLKVFC 540
  541 ISQSASSNRM LDTLGRVCQI SPRLAASYGQ PIIFQKFKEK LTHKGTKPIV VLNIFQIMKS 600
  601 MCEASSQSVA YIAHCGLPDV VANLNQTSDS VLVKELAKDL LKYLKVPQGP INEHKSPISK 660
  661 PHMPPPRWQP KQPLTQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	5.01
Match:	1wa5B
Description:	Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.96084803796407	bayes_pls_golite062009
nucleic acid binding	2.69616509670156	bayes_pls_golite062009
protein transporter activity	2.6734690782599	bayes_pls_golite062009
protein binding	2.66176697577398	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.31364900991203	bayes_pls_golite062009
transcription regulator activity	2.19067997822967	bayes_pls_golite062009
cation transmembrane transporter activity	2.04102668570108	bayes_pls_golite062009
ion transmembrane transporter activity	2.01138880938179	bayes_pls_golite062009
DNA binding	1.96172460362671	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.89164579147193	bayes_pls_golite062009
transporter activity	1.85346023606579	bayes_pls_golite062009
cytoskeletal protein binding	1.67265990792668	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.63680776259613	bayes_pls_golite062009
kinase activity	1.62528599136223	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.55513633605739	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.52026598954455	bayes_pls_golite062009
substrate-specific transporter activity	1.51565516399356	bayes_pls_golite062009
transcription activator activity	1.47146260606784	bayes_pls_golite062009
protein kinase activity	1.40981221970766	bayes_pls_golite062009
transferase activity	1.27106937966316	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.23631920875036	bayes_pls_golite062009
transcription factor activity	1.21493607378314	bayes_pls_golite062009
actin binding	0.864076688656138	bayes_pls_golite062009
protein transmembrane transporter activity	0.824035252349223	bayes_pls_golite062009
transmembrane transporter activity	0.710528717985301	bayes_pls_golite062009
protein serine/threonine kinase activity	0.647706371567682	bayes_pls_golite062009
enzyme regulator activity	0.632985761187158	bayes_pls_golite062009
protein phosphatase type 2A regulator activity	0.500648596452028	bayes_pls_golite062009
structural molecule activity	0.439909304123455	bayes_pls_golite062009
structure-specific DNA binding	0.333600669648793	bayes_pls_golite062009
RNA binding	0.243875756041061	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.109435859778099	bayes_pls_golite062009
clathrin binding	0.0923079381755934	bayes_pls_golite062009
protein phosphatase binding	0.0831993958662147	bayes_pls_golite062009
pyrophosphatase activity	0.0728493557966827	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0641324729536009	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0615190129942244	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.0342115143082778	bayes_pls_golite062009
GTPase regulator activity	0.0272200107208467	bayes_pls_golite062009
transcription factor binding	8.79739237675814E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: