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View Structure Prediction Details

Protein: alp13
Organism: Schizosaccharomyces pombe
Length: 337 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for alp13.

Description E-value Query
Range
Subject
Range
gi|94406757 - gi|94406757|ref|XP_981969.1| PREDICTED: similar to mortality factor 4 like 1 isoform b [Mus musculus...
341.0 [0..2] [333..8]
MO4L1_RAT - Mortality factor 4-like protein 1 OS=Rattus norvegicus GN=Morf4l1 PE=2 SV=1
338.0 [0..2] [333..8]
MG15_MOUSE - (P60762) Transcription factor-like protein MRG15 (MORF-related gene 15 protein) (Mortality factor 4-...
gi|114658397 - gi|114658397|ref|XP_001152351.1| PREDICTED: MORF-related gene 15 isoform 6 [Pan troglodytes]
gi|123984365, gi... - gi|168279109|dbj|BAG11434.1| mortality factor 4-like protein 1 [synthetic construct], gi|123998323|g...
gi|4454704, gi|1... - gi|8895208|gb|AAF80854.1|AF167173_1 MSL3-1 protein [Homo sapiens], gi|6841360|gb|AAF29033.1|AF161546...
gi|54035370 - gb|AAH84008.1| Unknown (protein for MGC:98166) [Xenopus laevis]
gi|109082086 - gi|109082086|ref|XP_001108662.1| PREDICTED: similar to mortality factor 4 like 1 isoform b isoform 3...
337.0 [0..2] [333..8]
gi|67968852 - gi|67968852|dbj|BAE00783.1| unnamed protein product [Macaca fascicularis]
337.0 [0..2] [333..8]
MO4L1_PONAB - Mortality factor 4-like protein 1 OS=Pongo abelii GN=MORF4L1 PE=2 SV=1
MO4L1_PONPY - Mortality factor 4-like protein 1 - Pongo pygmaeus (Orangutan)
334.0 [0..2] [333..8]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSYKVNER VLCFHGPLLY EAKIVDTEMK GDVTTYLIHY KGWKNSWDEW VEQDRILQWT  60
   61 EENLKTQKEL KNAAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 2efiA
Description: No description for 2efiA was found.

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
chromatin binding 3.84065302930105 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
satellite DNA binding 1.4681464542396 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [76-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STRQKPTSKK SASSTSKHDS TGVKTSGKRS RESSTVTVDG DSHELPSRIK TQKSESPIPQ  60
   61 QVKRDGTTDA KNEETTKPEN NEKDDFEEEP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [166-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLPKHKISVP DVLKLWLVDD WENITKNQQL IAIPRNPTVR AAIAAFRESK ISHLNNEIDV  60
   61 DVFEQAMAGL VIYFNKCLGN MLLYRFERQQ YLEIRQQYPD TEMCDLYGVE HLIRLFVSLP 120
  121 ELIDRTNMDS QSIECLLNYI EEFLKYLVLH KDEYFIKEYQ NAPPNYRSLV GV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.69897
Match: 2aqlA
Description: Crystal Structure of the MRG15 MRG domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle