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View Structure Prediction Details

Protein: alp13
Organism: Schizosaccharomyces pombe
Length: 337 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for alp13.

Description E-value Query
Range
Subject
Range
gi|94406757 - gi|94406757|ref|XP_981969.1| PREDICTED: similar to mortality factor 4 like 1 isoform b [Mus musculus...
341.0 [0..2] [333..8]
MO4L1_RAT - Mortality factor 4-like protein 1 OS=Rattus norvegicus GN=Morf4l1 PE=2 SV=1
338.0 [0..2] [333..8]
MG15_MOUSE - (P60762) Transcription factor-like protein MRG15 (MORF-related gene 15 protein) (Mortality factor 4-...
gi|114658397 - gi|114658397|ref|XP_001152351.1| PREDICTED: MORF-related gene 15 isoform 6 [Pan troglodytes]
gi|123984365, gi... - gi|168279109|dbj|BAG11434.1| mortality factor 4-like protein 1 [synthetic construct], gi|123998323|g...
gi|4454704, gi|1... - gi|8895208|gb|AAF80854.1|AF167173_1 MSL3-1 protein [Homo sapiens], gi|6841360|gb|AAF29033.1|AF161546...
gi|54035370 - gb|AAH84008.1| Unknown (protein for MGC:98166) [Xenopus laevis]
gi|109082086 - gi|109082086|ref|XP_001108662.1| PREDICTED: similar to mortality factor 4 like 1 isoform b isoform 3...
337.0 [0..2] [333..8]
gi|67968852 - gi|67968852|dbj|BAE00783.1| unnamed protein product [Macaca fascicularis]
337.0 [0..2] [333..8]
MO4L1_PONAB - Mortality factor 4-like protein 1 OS=Pongo abelii GN=MORF4L1 PE=2 SV=1
MO4L1_PONPY - Mortality factor 4-like protein 1 - Pongo pygmaeus (Orangutan)
334.0 [0..2] [333..8]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSYKVNER VLCFHGPLLY EAKIVDTEMK GDVTTYLIHY KGWKNSWDEW VEQDRILQWT  60
   61 EENLKTQKEL KNAAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 2efiA
Description: No description for 2efiA was found.

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
chromatin binding 3.84065302930105 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
satellite DNA binding 1.4681464542396 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [76-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STRQKPTSKK SASSTSKHDS TGVKTSGKRS RESSTVTVDG DSHELPSRIK TQKSESPIPQ  60
   61 QVKRDGTTDA KNEETTKPEN NEKDDFEEEP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [166-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLPKHKISVP DVLKLWLVDD WENITKNQQL IAIPRNPTVR AAIAAFRESK ISHLNNEIDV  60
   61 DVFEQAMAGL VIYFNKCLGN MLLYRFERQQ YLEIRQQYPD TEMCDLYGVE HLIRLFVSLP 120
  121 ELIDRTNMDS QSIECLLNYI EEFLKYLVLH KDEYFIKEYQ NAPPNYRSLV GV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.69897
Match: 2aqlA
Description: Crystal Structure of the MRG15 MRG domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle