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View Structure Prediction Details

Protein: Spt6-PA, FBpp0309041
Organism: Drosophila melanogaster
Length: 1831 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Spt6-PA, FBpp0309041.

Description E-value Query
Range
Subject
Range
gi|6491997 - gi|6491997|gb|AAF14114.1|AF104400_1 SPT6 protein [Drosophila melanogaster]
1245.0 [0..1] [1831..1]

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Predicted Domain #1
Region A:
Residues: [1-359]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEFLDSEAE ESEEEEELDV NERKRLKKLK AAVSDSSEEE EDDEERLREE LKDLIDDNPI  60
   61 EEDDGSGYDS DGVGSGKKRK KHEDDDLDDR LEDDDYDLIE ENLGVKVERR KRFKRLRRIH 120
  121 DNESDGEEQH VDEGLVREQI AEQLFDENDE SIGHRSERSH READDYDDVD TESDADDFIV 180
  181 DDNGRPIAEK KKKRRPIFTD ASLQEGQDIF GVDFDYDDFS KYEEDDYEDD SEGDEYDEDL 240
  241 GVGDDTRVKK KKALKKKVVK KTIFDIYEPS ELKRGHFTDM DNEIRKTDIP ERMQLREVPV 300
  301 TPVPEGSDEL DLEAEWIYKY AFCKHTVSEQ EKPESREKMR KPPTTVNKIK QTLEFIRNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.30103
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [360-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLEVPFIAFY RKEYVKPELN IDDLWKVYYY DGIWCQLNER KRKLKVLFEK MRQFQLDTLC  60
   61 A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [421-1336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTDQPVPDDV RLILDSDFER LADVQSMEEL KDVHMYFLLN YSHELPRMQA EQRRKAIQER  60
   61 REAKARRQAA AAENGDDAAE AIVVPEPEDD DDPELIDYQL KQASNSSPYA VFRKAGICGF 120
  121 AKHFGLTPEQ YAENLRDNYQ RNEITQESIG PTELAKQYLS PRFMTTDEVI HAAKYVVARQ 180
  181 LAQEPLLRKT MREVYFDRAR INIRPTKNGM VLIDENSPVY SMKYVAKKPV SDLFGDQFIK 240
  241 LMMAEEEKLL EITFLEEFEG NACANGTPGD YVEESKALYQ LDQFAKHVQE WNKLRAECVQ 300
  301 LALQKWVIPD LIKELRSTLH EEAQQFVLRS CTGKLYKWLK VAPYKPQLPP DFGYEEWSTL 360
  361 RGIRVLGLAY DPDHSVAAFC AVTTVEGDIS DYLRLPNILK RKNSYNLEEK AQKLADLRKL 420
  421 SDFIKMKKPH IVVIGAESRD AQNIQADIKE ILHELETSEQ FPPIEVEIID NELAKIYANS 480
  481 KKGESDFKEY PPLLKQAASL ARKMQDPLVE YSQLCDADDE ILCLRYHPLQ ERVPREQLLE 540
  541 QLSLQFINRT SEVGLDINLM VQNSRTINLL QYICGLGPRK GQALLKLLKQ SNQRLENRTQ 600
  601 LVTVCHLGPR VFINCSGFIK IDTSSLGDST EAYVEVLDGS RVHPETYEWA RKMAIDAMEY 660
  661 DDEETNPAGA LEEILESPER LKDLDLDAFA VELERQGFGS KSITLYDIRN ELSCLYKDYR 720
  721 TPYTKPSAEE LFDMLTKETP DSFYVGKCVT AMVTGFTYRR PQGDQLDSAN PVRLDSNESW 780
  781 QCPFCHKDDF PELSEVWNHF DANACPGQPS GVRVRLENGL PGFIHIKNLS DRQVRNPEER 840
  841 VRVSQMIHVR IIKIDIDRFS VECSSRTADL KDVNNEWRPR RDNYYDYVTE EQDNRKVSDA 900
  901 KARALKRKIY ARRVIA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 2oceA
Description: No description for 2oceA was found.

Predicted functions:

Term Confidence Notes
ribonuclease activity 4.78408578264511 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 4.47575558124516 bayes_pls_golite062009
exoribonuclease activity 4.45956182921702 bayes_pls_golite062009
3'-5'-exoribonuclease activity 3.99660019081433 bayes_pls_golite062009
nucleic acid binding 3.87899047526266 bayes_pls_golite062009
3'-5' exonuclease activity 3.51306349336452 bayes_pls_golite062009
DNA binding 3.47278447192966 bayes_pls_golite062009
binding 3.35781855253373 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3.07263153665399 bayes_pls_golite062009
exonuclease activity 2.66053639652924 bayes_pls_golite062009
structural constituent of ribosome 2.13063800565247 bayes_pls_golite062009
transcription regulator activity 2.10110937001387 bayes_pls_golite062009
structural molecule activity 1.9177190829469 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.36224060256697 bayes_pls_golite062009
excinuclease ABC activity 1.24466762466323 bayes_pls_golite062009
endonuclease activity 0.991569665925888 bayes_pls_golite062009
damaged DNA binding 0.95191912850966 bayes_pls_golite062009
transcription factor activity 0.937752547283357 bayes_pls_golite062009
sequence-specific DNA binding 0.76825863122436 bayes_pls_golite062009
protein binding 0.767256907671421 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.583085644017496 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
translation regulator activity 0.515576958825022 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.510809870824979 bayes_pls_golite062009
RNA polymerase activity 0.510809870824979 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.468402630523277 bayes_pls_golite062009
telomeric DNA binding 0.361382760487809 bayes_pls_golite062009
deoxyribonuclease activity 0.24906263529692 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.233952169113693 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
RNA binding 0.18502033889261 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.09423425042945 bayes_pls_golite062009
DNA polymerase activity 0.0189279348688405 bayes_pls_golite062009
endoribonuclease activity 0.016619833072142 bayes_pls_golite062009
chromatin binding 0.0075451629397203 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1337-1474]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPSFFNKSYA EVVAMLAEAD QGEVALRPSS KSKDHLTATW KVADDIFQHI DVREEGKEND  60
   61 FSLGRSLWIG TEEFEDLDEI IARHIMPMAL AARELIQYKY YKPNMVTGDE NERDVMEKLL 120
  121 REEKANDPKK IHYFFTAS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.91
Match: 1ka6A
Description: The Xlp protein Sap
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.53841763802611 bayes_pls_golite062009
protein binding 2.59400723645972 bayes_pls_golite062009
transcription regulator activity 2.33050919783116 bayes_pls_golite062009
DNA binding 1.69194220365195 bayes_pls_golite062009
nucleic acid binding 1.68849923149905 bayes_pls_golite062009
transcription factor activity 1.02720628759707 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.364108622844773 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1475-1831]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAMPGKFLLS YLPKTKVRHE YVTVMPEGYR FRGQIFDTVN SLLRWFKEHW LDPTATPASA  60
   61 SASNLTPLHL MRPPPTISSS SQTSLGPQAP YSVTGSVTGG TPRSGISSAV GGGGSSAYSI 120
  121 TQSITGYGTS GSSAPGAGVS SSHYGSSSTP SFGAINTPYT PSGQTPFMTP YTPHASQTPR 180
  181 YGHNVPSPSS QSSSSQRHHY GSSSGTGSTP RYHDMGGGGG GGVGGGGGSN AYSMQPHHQQ 240
  241 RAKENLDWQL ANDAWARRRP QQHQSHQSYH AQQQHHHSQQ QPHMGMSMNM GITMSLGRGT 300
  301 GGGGGGGYGS TPVNDYSTGG GHNRGMSSKA SVRSTPRTNA SPHSMNLGDA TPLYDEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.221849
Match: 1y0fB
Description: No description for 1y0fB was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle