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View Structure Prediction Details

Protein: FBpp0305122, FBp...
Organism: Drosophila melanogaster
Length: 742 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0305122, FBp....

Description E-value Query
Range
Subject
Range
CG42666-PF, CG42... - This gene is referred to in FlyBase by the symbol Dmel\CG42666 (CG42666, FBgn0261548).The gene has a...
475.0 [0..1] [742..20]

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Predicted Domain #1
Region A:
Residues: [1-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSCNKNSSS RITTTNNNVT TTSNISGNSS NKRCPQKYTG NTLAVNSNML AYQQQATAGG  60
   61 KNSTRKSRHN NNKQNHQQQQ QQQQQQFDHI HKRNGTAGGT GSECSPAAPT SNWLQRGYGR 120
  121 QFVHSSCIED KLLGHHNPG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [140-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRNSTSSDAT SEDIDSSSEL PNKSKGNSCA GSIHASGGSK SRSKRHQKQS GQQTRNPDHN  60
   61 GQRTGAATPC TGQKAKQGNA KWRQQQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [226-356]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPSSNNQQQ QMQQQMQQQK RGRNKKPGKW SNNIIDNPNS NHGGSSQQKT CDSSSSSALS  60
   61 SPTSSATTSA TSSPTNSPTS YPRANGNRKR IEAALEWRRE QELGRQNANF LVPPLRQYEQ 120
  121 LEFDDKTVVQ Q

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [357-485]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRRHIIDNHL LRVYGFPVDS VVHEGAIEIF KCMPHMSFAA ALAETAQAVT VINYHDGLTN  60
   61 RAEEEVANST DSGNSSPQSL DSESGGEWSG SECESSNSSS SSAGEAALGL ELKYCHFVPV 120
  121 ERSLSKPCA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [486-572]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RCKRHFLVDE LTGQYLTHEE CQYHSGKYQR YYDGVSHGRW TCCNEGEESS PGCCLGDRHV  60
   61 WSGSVVGVNG PYYDFVRTEH RGSGEDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [573-742]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAVYALDCEM SYTGRGLDVT KVSLVALNGQ LVYEHFVRPV CDIIDYNTQY SGITETDLCS  60
   61 GAKSLAEVQR DLLQLITADT ILIGHGLEND LRALRLVHNT LIDTSISFPH CNGFPYRRAL 120
  121 RHLTKVHLKR DIQAGDGTTG HSSFEDSRAC MELMLWRVNR ELDPAWSWDD 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.0
Match: 1wljA
Description: human ISG20
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 5.30591758406946 bayes_pls_golite062009
exoribonuclease activity 3.71639182685131 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 3.59362615133405 bayes_pls_golite062009
3'-5'-exoribonuclease activity 3.1992647486402 bayes_pls_golite062009
exonuclease activity 3.13676176369406 bayes_pls_golite062009
nuclease activity 3.11657409772275 bayes_pls_golite062009
ribonuclease H activity 2.91966688044755 bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 2.75003136922541 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.57498413015114 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.04408785855894 bayes_pls_golite062009
3'-5' exonuclease activity 1.44123900197846 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
nucleic acid binding 1.23371034593624 bayes_pls_golite062009
protein binding 1.16870279238939 bayes_pls_golite062009
deoxyribonuclease activity 1.1219517187744 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
DNA binding 0.860359347662869 bayes_pls_golite062009
binding 0.762139256580538 bayes_pls_golite062009
DNA polymerase activity 0.717600245625866 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.568273228950698 bayes_pls_golite062009
0.49473250705373 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009
exodeoxyribonuclease activity 0.278838342302102 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.261428436029202 bayes_pls_golite062009
structure-specific DNA binding 0.0701825322473915 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.00214157813118243 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle