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View Structure Prediction Details

Protein: mus81-PA
Organism: Drosophila melanogaster
Length: 426 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mus81-PA.

Description E-value Query
Range
Subject
Range
gi|10437000 - gi|10437000|dbj|BAB14953.1| unnamed protein product [Homo sapiens]
328.0 [0..9] [423..72]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METRLEVLLR EPNPLFTRWL ERWLREAERR EQKSQFSLRQ ALESLKSYPL PLASGRDCSI  60
   61 LRGFGGTLCQ LIDEELRHHR GLQLLPQEAV VQERYEQQVQ AVVRKVQEKQ LEHQKRQNKC 120
  121 DRPRKLTKKD LAELAAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1wp9A
Description: Crystal structure of Pyrococcus furiosus Hef helicase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [138-426]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EERERVVRMK PGQFQLLLLV DTQETSGKNK RVLDQTRSYL ESLGARHEVR RLTIGDFLWV  60
   61 AQDQEGNELV LPYIVERKRM DDLASSIRDG RFHEQKHRLQ HCGLQHIIYL VEDYGDNEQL 120
  121 GLPLDSLQQA LTNAKVQTGV RVVRTANHYR SMSYLAGMSR TLGQIFAGKK LHSVDRGAID 180
  181 QSTCLLTHSD LGLLKFRALY EDSAKNAQLT VREVFVQQLL QLHSLSLERA MAIVERYPTP 240
  241 RWLLDAYAEC ADQKQARLLL ASIPCGPLER PLGDKISQCL HEFYSTHFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 2bgwA
Description: XPF from Aeropyrum pernix, complex with DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
four-way junction helicase activity 2.93834618926168 bayes_pls_golite062009
deoxyribonuclease activity 2.38833494621917 bayes_pls_golite062009
endodeoxyribonuclease activity 2.33372429725567 bayes_pls_golite062009
DNA helicase activity 1.83146987493465 bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity 1.42238952652053 bayes_pls_golite062009
catalytic activity 1.18688703641003 bayes_pls_golite062009
helicase activity 1.14079869095094 bayes_pls_golite062009
nuclease activity 0.90252859343276 bayes_pls_golite062009
endonuclease activity 0.87027578644028 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.70849567386272 bayes_pls_golite062009
hydrolase activity 0.7029472543514 bayes_pls_golite062009
structure-specific DNA binding 0.67049159133539 bayes_pls_golite062009
single-stranded DNA binding 0.66774107373566 bayes_pls_golite062009
excinuclease ABC activity 0.66562067290586 bayes_pls_golite062009
protein binding 0.330444531124157 bayes_pls_golite062009
binding 0.240779272133325 bayes_pls_golite062009
DNA binding 0.0778795682272901 bayes_pls_golite062009
pyrophosphatase activity 0.0669727336969201 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.05756449780621 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0572628370858399 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0554315973046002 bayes_pls_golite062009
nucleic acid binding 0.051221107975965 bayes_pls_golite062009

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