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View Structure Prediction Details

Protein: Sox100B-PA
Organism: Drosophila melanogaster
Length: 529 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sox100B-PA.

Description E-value Query
Range
Subject
Range
gi|32450384, gi|... - gi|32450384|gb|AAH54148.1| Hmgb1-prov protein [Xenopus laevis], gi|148234528|ref|NP_001080836.1| hig...
177.0 [0..9] [145..25]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSSSNCS KDRAKPVETL VLANYALKAE QKKAQGQGGR KEDERITTAV MKVLEGYDWN  60
   61 LVQASAKAPT DRKKEHIKRP M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.221849
Match: 1aabA
Description: NMR STRUCTURE OF RAT HMG1 HMGA FRAGMENT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
nucleic acid binding 4.70730250099648 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
sequence-specific DNA binding 2.96229555092695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.84606709725198 bayes_pls_golite062009
transcription activator activity 1.62744929149746 bayes_pls_golite062009
transcription repressor activity 1.53825678633232 bayes_pls_golite062009
protein binding 1.131658134984 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
chromatin binding 0.830960835937769 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [82-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAFMVWAQAA RRVMSKQYPH LQNSELSKSL GKLWKNLKDS DKKPFMEFAE KLRMTHKQEH  60
   61 PDYKYQPRRK KARVLPSQQS GEGGSPGPEM TLSATMGSSG KPRSSNSNGQ RRAGKGNAAA 120
  121 DLGSCASTIS HANVGSNSSD VFSNEAFMKS LNSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 2gzkA
Description: No description for 2gzkA was found.

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
nucleic acid binding 4.70730250099648 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
sequence-specific DNA binding 2.96229555092695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.84606709725198 bayes_pls_golite062009
transcription activator activity 1.62744929149746 bayes_pls_golite062009
transcription repressor activity 1.53825678633232 bayes_pls_golite062009
protein binding 1.131658134984 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
chromatin binding 0.830960835937769 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [236-349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CAASLMEQSL IETGLDSPCS TASSMSSLTP PATPYNVAPS NAKASAANNP SLLLRQLSEP  60
   61 VANAGDGYGV LLEAGREYVA IGEVNYQGQS AGVQSGAEGG GAGQEMDFLE NING

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [350-529]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGGYTGSRVS YPAYSYPANG GHFATEEQQQ QQALQASEAL NYKPAAADID PKEIDQYFMD  60
   61 QMLPMTQHHH PHHTHPLHHP LHHSPPLNSS ASLSSACSSA SSQQPVAEYY EHLGYSPAAS 120
  121 SASQNPNFGP QQPYANGAAS MTPTLGDPAP QQELQSQQQE QQHQNPSQHH LWGTYTYVNP 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle