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View Structure Prediction Details

Protein: Sox100B-PA
Organism: Drosophila melanogaster
Length: 529 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sox100B-PA.

Description E-value Query
Range
Subject
Range
gi|32450384, gi|... - gi|32450384|gb|AAH54148.1| Hmgb1-prov protein [Xenopus laevis], gi|148234528|ref|NP_001080836.1| hig...
177.0 [0..9] [145..25]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSSSNCS KDRAKPVETL VLANYALKAE QKKAQGQGGR KEDERITTAV MKVLEGYDWN  60
   61 LVQASAKAPT DRKKEHIKRP M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.221849
Match: 1aabA
Description: NMR STRUCTURE OF RAT HMG1 HMGA FRAGMENT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
nucleic acid binding 4.70730250099648 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
sequence-specific DNA binding 2.96229555092695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.84606709725198 bayes_pls_golite062009
transcription activator activity 1.62744929149746 bayes_pls_golite062009
transcription repressor activity 1.53825678633232 bayes_pls_golite062009
protein binding 1.131658134984 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
chromatin binding 0.830960835937769 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [82-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAFMVWAQAA RRVMSKQYPH LQNSELSKSL GKLWKNLKDS DKKPFMEFAE KLRMTHKQEH  60
   61 PDYKYQPRRK KARVLPSQQS GEGGSPGPEM TLSATMGSSG KPRSSNSNGQ RRAGKGNAAA 120
  121 DLGSCASTIS HANVGSNSSD VFSNEAFMKS LNSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 2gzkA
Description: No description for 2gzkA was found.

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
nucleic acid binding 4.70730250099648 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
sequence-specific DNA binding 2.96229555092695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.84606709725198 bayes_pls_golite062009
transcription activator activity 1.62744929149746 bayes_pls_golite062009
transcription repressor activity 1.53825678633232 bayes_pls_golite062009
protein binding 1.131658134984 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
chromatin binding 0.830960835937769 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [236-349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CAASLMEQSL IETGLDSPCS TASSMSSLTP PATPYNVAPS NAKASAANNP SLLLRQLSEP  60
   61 VANAGDGYGV LLEAGREYVA IGEVNYQGQS AGVQSGAEGG GAGQEMDFLE NING

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [350-529]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGGYTGSRVS YPAYSYPANG GHFATEEQQQ QQALQASEAL NYKPAAADID PKEIDQYFMD  60
   61 QMLPMTQHHH PHHTHPLHHP LHHSPPLNSS ASLSSACSSA SSQQPVAEYY EHLGYSPAAS 120
  121 SASQNPNFGP QQPYANGAAS MTPTLGDPAP QQELQSQQQE QQHQNPSQHH LWGTYTYVNP 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle