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View Structure Prediction Details

Protein: Cyp4ad1-PA
Organism: Drosophila melanogaster
Length: 516 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cyp4ad1-PA.

Description E-value Query
Range		 Subject
Range
gi|115496944, gi... - gi|94574282|gb|AAI16042.1| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi|1...
 381.0 [0..25] [499..20]

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Predicted Domain #1
Region A:
Residues: [1-516] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLIAIAIIL ATILVFKGVR IFNYIDHMAG IMEMIPGPTP YPFVGNLFQF GLKPAEYPKK  60
   61 VLQYCRKYDF QGFRSLVFLQ YHMMLSDPAE IQNILSSSSL LYKEHLYSFL RPWLGDGLLT 120
  121 SSGARWLKHQ KLYAPAFERS AIEGYLRVVH RTGGQFVQKL DVLSDTQEVF DAQELVAKCT 180
  181 LDIVCENATG QDSSSLNGET SDLHGAIKDL CDVVQERTFS IVKRFDALFR LTSYYMKQRR 240
  241 ALSLLRSELN RIISQRRHQL AAENTCQQGQ PINKPFLDVL LTAKLDGKVL KEREIIEEVS 300
  301 TFIFTGHDPI AAAISFTLYT LSRHSEIQQK AAEEQRRIFG ENFAGEADLA RLDQMHYLEL 360
  361 IIRETLRLYP SVPLIARTNR NPIDINGTKV AKCTTVIMCL IAMGYNEKYF DDPCTFRPER 420
  421 FENPTGNVGI EAFKSVPFSA GPRRCIAEKF AMYQMKALLS QLLRRFEILP AVDGLPPGIN 480
  481 DHSREDCVPQ SEYDPVLNIR VTLKSENGIQ IRLRKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.30103
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
electron carrier activity 4.64931978461551 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxygen binding 3.7203678182299 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
fluorene oxygenase activity 3.16634614522939 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
thromboxane-A synthase activity 2.45281910634006 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 2.30416050662077 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.21042366294727 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 2.036553099796 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 2.0071742914584 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 2.0071742914584 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity 1.58167166311061 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 1.00908437413492 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.614118857213859 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
iron ion binding 0.529598228513719 bayes_pls_golite062009
cation binding 0.510556740388808 bayes_pls_golite062009
metal ion binding 0.510556740388808 bayes_pls_golite062009
ion binding 0.503326724714616 bayes_pls_golite062009
transition metal ion binding 0.450436868179747 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors 0.377799149936808 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
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