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Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Catalysis of the hydroxylation of C-25 of any form of vitamin D.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: vitamin D 25-hydroxylase activity
Acc: GO:0070643
Aspect: Molecular Function
Desc: Catalysis of the hydroxylation of C-25 of any form of vitamin D.
Synonyms:
  • calciferol 25-hydroxylase activity
  • vitamin D2 25-hydroxylase activity
  • ergocalciferol 25-hydroxylase activity
  • cholecalciferol 25-hydroxylase activity
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070643 - vitamin D 25-hydroxylase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle