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View Structure Prediction Details

Protein: mus205-PA
Organism: Drosophila melanogaster
Length: 2130 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mus205-PA.

Description E-value Query
Range
Subject
Range
gi|11096177 - gi|11096177|gb|AAG30223.1| DNA polymerase zeta catalytic subunit [Drosophila melanogaster]
1224.0 [0..1] [2130..1]

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Predicted Domain #1
Region A:
Residues: [1-251]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAGEAIDG VYSVRLVIAD FYMEKPQFGM DPCYSELRGK EIKRVPVIRV FGGNSRGQKT  60
   61 CMHVHGVFPY LYIPYDKKDF ESLERGILQM AMHLDKAINI SLGQGSSNAQ HVFKIQLVKG 120
  121 IPFYGYHRVE HQFLKIYMFN PRFVRRAANL LQSGAILSKN FSPHESHVPY ILQFMIDYNL 180
  181 YGMSYVHVPL EVLKFRRNHD DDVIPYANVK QAQLLDITTA KKVACSALEV DVSSNFILNR 240
  241 FQLVAKSKSN H

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.66
Match: 1q8iA
Description: Crystal structure of ESCHERICHIA coli DNA Polymerase II
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [252-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNPGIEAIWN DEKLRRQKLV EKHTDAGDEE KAEAVPVLEL PPTQERHQIE IAESDIFYRT  60
   61 ALESKLMTLE QSTLSEQTLS DQTILPQATM QTTMPGTKAQ KRRFNLQKLL A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [363-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAVYPEECSQ DQQQLLVNAS FIQNHVTCGY SSSVSLSTSK DESDDLDETV VDEELILSLT  60
   61 QPHGAIPHDA TLREEDLELL DALQLLEEQN ESESHVDLDS SLAPLSQHKK FELTPELLDK 120
  121 ETAATAALFD EDVDSDEDAD QETRHDFSTV LDDVDELLLK LTQSQPAESK ELKASSKLPQ 180
  181 IDGADDRLQR TP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [555-997]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKSISSKSKS SPSKTPTTPI GQKSLPKSPR TPKTSAAKKY APLALTIGSS SSKKSNDEFA  60
   61 GRPSNPRLSL QLDQGTGTGT LRPEISLRKK LAMSEMRRKS FEDSFVLLKN DCTPVRSTRR 120
  121 STSNLDKTHI ICSLTPRDRN PGLSDMFETE DGKQLPPKKV VRKTRWSTRN QDIESLPKAG 180
  181 CEIERPHRSE GSALDELKPR RSARHKVNSA NPDECSSEIQ TTGPRVTTTS LDRPQKKARL 240
  241 SQSPKENTKT SMNGTVALEK ATKDSSSNSE SPHQQENSVS EQIEYLESKP KKSDETARSC 300
  301 DEKLQRELIP QEPAGISPGD SANSTEEITF SPCHDEAIES DTESDYIVTK LRKTPNLKRL 360
  361 RWSIRSELLN KQFTPSSGIR PPETETTPQL SPKSNESNTP ELMRSFYEHS LIVNSPSVFS 420
  421 DFLDSPEIHM DSPRSAPPSP DSN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.24
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [998-1159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFVIAPLELP PSYDEVVSGS RKMDIPEYEF QKPYYSNPSD VSKVTEVGFL VLHIPGNKLN  60
   61 DCDPFQSILG NDRGLASWRR RQLIAIGGLA MLQRHRGEQK VREYFSTQQR IAIEPAQLAP 120
  121 TWQEAKIWLK AKELLRQREE PKKSSDDIDS PIKIKRQKIT MM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1160-2019]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQAEEGDGGS GDEDAGEELD CSLSLTPLSQ AKDKCKATPT SSKARETGKS RLKRGTRLSF  60
   61 IGSQDEEPPS SQSSEQSVSS SAAQAELDRS SFLRQLEGSS QDRQHDLSFG LSHATLDNTF 120
  121 GFKVNLENLQ QAKADIDCNH LTIITLEVFV STRGDLQPDP MHDEIRCLFY AIEHSLPDEK 180
  181 LPSKACGYIM VNTVQDLLSE GPFHGIDRDI EVQVVTSEAE AFEALLALCE RWDADIYAGY 240
  241 EIEMSSWGYV IDRAKHLCFN IAPLLSRVPT QKVRDFVDED REQFTDLDVE MKLCGRILLD 300
  301 VWRLMRSEIA LTSYTFENVM YHILHKRCPW HTAKSLTEWF GSPCTRWIVM EYYLERVRGT 360
  361 LTLLDQLDLL GRTSEMAKLI GIQFYEVLSR GSQFRVESMM LRIAKPKNLV PLSPSVQARA 420
  421 HMRAPEYLAL IMEPQSRFYA DPLIVLDFQS LYPSMIIAYN YCFSTCLGRV EHLGGSSPFE 480
  481 FGASQLRVSR QMLQKLLEHD LVTVSPCGVV FVKREVREGI LPRMLTEILD TRQMVKQSMK 540
  541 LHKDSSALQR ILHSRQLGLK LMANVTYGYT AANFSGRMPS VEVGDSVVSK GRETLERAIK 600
  601 LVENNEEWKV RVVYGDTDSM FVLVPGRNRA EAFRIGEEIA KAVTEMNPQP VKLKLEKVYQ 660
  661 PCMLQTKKRY VGYMYETADQ EQPVYEAKGI ETVRRDGCPA VAKMLEKVLR ILFETQDVSK 720
  721 IKAYVCRQFT KLLSGRANLQ DLIFAKEFRG LNGYKPTACV PALELTRKWM QKDPRHVPRR 780
  781 GERVPFIIVN GPPGMQLIRL VRSPHDILAN EGHKINAIYY ITKAIIPPLN RCLLLIGANV 840
  841 HDWFASLPRK LLMTPAVGTA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 173.0
Match: 1tgoA
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed DNA polymerase activity 11.2781960093187 bayes_pls_golite062009
DNA polymerase activity 11.2285838712952 bayes_pls_golite062009
nucleotidyltransferase activity 8.85826259809475 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.79232184185512 bayes_pls_golite062009
transferase activity 4.02382113115178 bayes_pls_golite062009
DNA primase activity 1.77742223999604 bayes_pls_golite062009
exonuclease activity 1.42205333874102 bayes_pls_golite062009
ribonuclease activity 1.41033617404868 bayes_pls_golite062009
RNA polymerase activity 1.16960098510532 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.16960098510532 bayes_pls_golite062009
catalytic activity 1.04899053677564 bayes_pls_golite062009
nucleic acid binding 0.959511000267266 bayes_pls_golite062009
endonuclease activity 0.935348031740788 bayes_pls_golite062009
DNA binding 0.86778938742546 bayes_pls_golite062009
binding 0.808919229163124 bayes_pls_golite062009
endodeoxyribonuclease activity 0.48776342704945 bayes_pls_golite062009
damaged DNA binding 0.39441061793492 bayes_pls_golite062009
exoribonuclease activity 0.14466215642144 bayes_pls_golite062009
transcription regulator activity 0.126013788737514 bayes_pls_golite062009
protein binding 0.101829155879905 bayes_pls_golite062009
3'-5' exonuclease activity 0.0700154911930899 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.0662718964590603 bayes_pls_golite062009
nuclease activity 0.0574785418962505 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [2020-2130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NELAGARGAK STISQYFSTT SCVIDCGRQT KAGICPDCLK NATTCVVVLS DKTARLERGY  60
   61 QLTRQICQAC CGRLGSLQCD SLDCPVLYVL EGKRRELQQI EHWNKLLEHH F

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.0
Match: 2cklB
Description: No description for 2cklB was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle