YRC Public Data Repository - Protein Structure Prediction

Protein:	PIPNB_MOUSE
Organism:	Mus musculus
Length:	271 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PIPNB_MOUSE.

Description	E-value	Query Range	Subject Range
PIPNB_RAT - Phosphatidylinositol transfer protein beta isoform OS=Rattus norvegicus GN=Pitpnb PE=1 SV=2	496.0	[0..1]	[271..1]
HGNC:9002\|MIM:60... - transfer protein, beta ENSMMUT000000203... - null, null CCDS13842.1_1 - null gi\|109451422, gi... - gi\|109452018\|emb\|CAK54871.1\| PITPNB [synthetic construct], gi\|109451422\|emb\|CAK54572.1\| PITPNB [synt... PITPNB - phosphatidylinositol transfer protein, beta gi\|55660937 - gi\|55660937\|ref\|XP_515049.1\| PREDICTED: phosphatidylinositol transfer protein, beta isoform 2 [Pan t...	495.0	[0..1]	[270..1]
gi\|73994863 - gi\|73994863\|ref\|XP_864759.1\| PREDICTED: similar to Phosphatidylinositol transfer protein beta isofor... PIPNB_BOVIN - Phosphatidylinositol transfer protein beta isoform OS=Bos taurus GN=PITPNB PE=1 SV=3 gi\|194043162 - gi\|194043162\|ref\|XP_001927816.1\| PREDICTED: similar to Phosphatidylinositol transfer protein beta is...	494.0	[0..1]	[270..1]
gi\|76673605 - gi\|76673605\|ref\|XP_877440.1\| PREDICTED: similar to Phosphatidylinositol transfer protein beta isofor...	493.0	[0..1]	[270..1]
gi\|21961612 - gi\|21961612\|gb\|AAH34676.1\| Pitpnb protein [Mus musculus]	492.0	[0..1]	[269..1]
gi\|192282136, gi... - gi\|21594294\|gb\|AAH31427.1\| PITPNB protein [Homo sapiens], gi\|192282136\|emb\|CAQ68296.1\| phosphatidyli... gi\|114685620 - gi\|114685620\|ref\|XP_001172543.1\| PREDICTED: phosphatidylinositol transfer protein, beta isoform 1 [P... gi\|109093701 - gi\|109093701\|ref\|XP_001101197.1\| PREDICTED: phosphatidylinositol transfer protein, beta [Macaca mula...	491.0	[0..1]	[269..1]
PIPNB_PONAB - Phosphatidylinositol transfer protein beta isoform OS=Pongo abelii GN=PITPNB PE=2 SV=3 PIPNB_PONPY - Phosphatidylinositol transfer protein beta isoform - Pongo pygmaeus (Orangutan)	488.0	[0..1]	[269..1]

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Predicted Domain #1

Region A:
Residues: [1-271]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEN DGEKGQYTHK  60
   61 IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG 120
  121 TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFHSVKTKR GPLGPNWKKE 180
  181 LANTPDCPRM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNLHRQLFC WIDKWIDLTM 240
  241 EDIRRMEDET QKELETMRKK GSVRGTSAAD A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	140.0
Match:	2a1lA
Description:	Rat PITP-Beta Complexed to Phosphatidylcholine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phospholipid transporter activity	5.13837461289632	bayes_pls_golite062009
lipid transporter activity	4.4358073696145	bayes_pls_golite062009
phosphatidylinositol transporter activity	2.88424241201993	bayes_pls_golite062009
transporter activity	2.27726025087174	bayes_pls_golite062009
substrate-specific transporter activity	2.15798050058248	bayes_pls_golite062009
binding	2.03322388415011	bayes_pls_golite062009
sterol binding	1.50607153716429	bayes_pls_golite062009
cholesterol binding	1.15123926171731	bayes_pls_golite062009
transmembrane transporter activity	1.09413284791115	bayes_pls_golite062009
phosphatidylcholine transmembrane transporter activity	0.917631923888787	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.584604660695011	bayes_pls_golite062009
cholesterol transporter activity	0.478721911308239	bayes_pls_golite062009
protein binding	0.43929659331502	bayes_pls_golite062009
sterol transporter activity	0.35901111584592	bayes_pls_golite062009
ion transmembrane transporter activity	0.295257921753146	bayes_pls_golite062009
active transmembrane transporter activity	0.286459038638072	bayes_pls_golite062009
primary active transmembrane transporter activity	0.265156292873733	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.256503527440737	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.21859262454477	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.215063584310921	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.214776368903272	bayes_pls_golite062009
lipid binding	0.144022082146249	bayes_pls_golite062009
steroid binding	0.136743971526566	bayes_pls_golite062009
cation transmembrane transporter activity	0.0954103313829049	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0415343979510595	bayes_pls_golite062009
catalytic activity	0.0116392906163881	bayes_pls_golite062009
pyrophosphatase activity	0.00274551209125462	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: