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View Structure Prediction Details

Protein: Dscam-PBC
Organism: Drosophila melanogaster
Length: 2030 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PBC.

Description E-value Query
Range
Subject
Range
Dscam-PAJ - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1548.0 [0..3] [2030..3]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.154902
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [139-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFFESQVYDE YVIKGNAAIF KCQTPSFVAD HIDITDWIDT EGEVFTKNIT DGKYLVLPSG  60
   61 ELHIREVGPE DGYKSYQCRT KHRLTGETRL SATKGRLVIT EPIGSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1f3rB
Description: Immunoglobulin light chain kappa variable domain, VL-kappa; Immunoglobulin heavy chain variable domain, VH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
olfactory receptor activity 4.21057154107121 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
peptide antigen binding 2.94721224577771 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.83860944503193 bayes_pls_golite062009
growth factor binding 2.28613301180608 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
extracellular matrix structural constituent 1.97667893885412 bayes_pls_golite062009
IgG binding 1.92633562075074 bayes_pls_golite062009
receptor binding 1.70260377709721 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.52958974617075 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.30657787244536 bayes_pls_golite062009
fibroblast growth factor binding 1.27793818082552 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.24730237107473 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
collagen binding 0.635057461053063 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
myosin heavy chain binding 0.49788128784685 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [245-908]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPKITSLHDK FQVLQVKLAE DFSMQCPGQA YPVPIVRWYK FIEGTTRKQA VVLNDRVKQV  60
   61 SGTLIIKDAV VEDSGKYLCV VNNSVGGESV ETVLTVTAPL SAKIDPPTQT VDFGRPAVFT 120
  121 CQYTGNPIKT VSWMKDGKAI GHSEPVLRIE SVKKEDKGMY QCFVRNDQES AEASAELKLG 180
  181 GRFDPPVIRQ AFQEETMEPG PSVFLKCVAG GNPTPEISWE LDGKKIANND RYQVGQYVTV 240
  241 NGDVVSYLNI TSVHANDGGL YKCIAKSKVG VAEHSAKLNV YGLPYIRQME KKAIVAGETL 300
  301 IVTCPVAGYP IDSIVWERDN RALPINRKQK VFPNGTLIIE NVERNSDQAT YTCVAKNQEG 360
  361 YSARGSLEVQ VMVPPKLAPL PVNSPLYVGD YYQLTCAVVH GDAPFNITWY YNNEPAGDLA 420
  421 GVTILMHGRR SSSLNIESVG GDHAGNYTCK GANRAGETTA ETHLSVKVPP RWILEPTDKA 480
  481 FAQGSDAKVE CKADGFPKPQ VTWKKAVGDT PGEYKDLKKS DNIRVEEGTL HVDNIQKTNE 540
  541 GYYLCEAING IGSGLSAVIM ISVQAPPEFT EKLRNQTARR GEPAVLQCEA KGEKPIGILW 600
  601 NMNNMRLDPK NDNRYTIREE ILSTGVMSSL SIKRTERSDS ALFTCVATNA FGSDDASINM 660
  661 IVQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.30103
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [909-1003]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEMPYALKV LDKSGRSVQL SWAQPYDGNS PLDRYIIEFK RSRASWSEID RVIVPGHTTE  60
   61 AQVQKLSPAT TYNIRIVAEN AIGTSQSSEA VTIIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #5
Region A:
Residues: [1004-1101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEEAPSGKPQ NIKVEPVNQT TMRVTWKPPP RTEWNGEILG YYVGYKLSNT NSSYVFETIN  60
   61 FITEEGKEHN LELQNLRVYT QYSVVIQAFN KIGAGPLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1va9A
Description: Solution structure of the second FNIII domain of DSCAML1 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
transmembrane receptor activity 4.81256300373074 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
receptor activity 4.66147271961356 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
molecular transducer activity 3.69234048247377 bayes_pls_golite062009
signal transducer activity 3.69234048247377 bayes_pls_golite062009
extracellular matrix structural constituent 3.5949595622742 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
growth hormone receptor activity 1.94500909454564 bayes_pls_golite062009
mercury ion binding 1.85843060232985 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
cytokine activity 1.09433218752101 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
peptide binding 0.92031154055894 bayes_pls_golite062009
interleukin-6 receptor activity 0.888638861691021 bayes_pls_golite062009
interleukin-6 binding 0.888638861691021 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
pattern binding 0.44460010885883 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
cell surface binding 0.366415248711076 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protease binding 0.12595904253108 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1102-1212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEKQFTAEG TPSQPPSDTA CTTLTSQTIR VGWVSPPLES ANGVIKTYKV VYAPSDEWYD  60
   61 ETKRHYKKTA SSDTVLHGLK KYTNYTMQVL ATTAGGDGVR SVPIHCQTEP D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 1qg3A
Description: Integin beta-4 subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1213-1309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEAPTDVKA LVMGNAAILV SWRPPAQPNG IITQYTVYSK AEGAETETKT QKVPHYQMSF  60
   61 EATELEKNKP YEFWVTASTT IGEGQQSKSI VAMPSDQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1wfnA
Description: The fourth FN3 domain of human sidekick-2
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1310-1386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPAKIASFDD TFTATFKEDA KMPCLAVGAP QPEITWKIKG VEFSANDRMR VLPDGSLLIK  60
   61 SVNRQDAGDY SCHAENS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.13
Match: 2yr3A
Description: No description for 2yr3A was found.

Predicted Domain #9
Region A:
Residues: [1387-1493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAKDSITHKL IVLAPPQSPH VTLSATTTDA LTVKLKPHEG DTAPLHGYTL HYKPEFGEWE  60
   61 TSEVSVDSQK HNIEGLLCGS RYQVYATGFN NIGAGEASDI LNTRTKG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 1x5iA
Description: The solution structure of the fourth fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
transmembrane receptor activity 4.81256300373074 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
receptor activity 4.66147271961356 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
molecular transducer activity 3.69234048247377 bayes_pls_golite062009
signal transducer activity 3.69234048247377 bayes_pls_golite062009
extracellular matrix structural constituent 3.5949595622742 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
growth hormone receptor activity 1.94500909454564 bayes_pls_golite062009
mercury ion binding 1.85843060232985 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
cytokine activity 1.09433218752101 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
peptide binding 0.92031154055894 bayes_pls_golite062009
interleukin-6 receptor activity 0.888638861691021 bayes_pls_golite062009
interleukin-6 binding 0.888638861691021 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
pattern binding 0.44460010885883 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
cell surface binding 0.366415248711076 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protease binding 0.12595904253108 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1494-1663]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKPKLPEKPR FIEVSSNSVS LHFKAWKDGG CPMSHFVVES KKRDQIEWNQ ISNNVKPDNN  60
   61 YVVLDLEPAT WYNLRITAHN SAGFTVAEYD FATLTVTGGT IAPLDDGSGH GNVHTRIRLP 120
  121 AWMPEWLDLN FMVPLIATVV VVAVGICVVC VALSRRRADD MRGGQKDVYY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.154902
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #11
Region A:
Residues: [1664-1841]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVVYNQTMGP GATLDKRRPD LRDELGYIAP PNRKLPPVPG SNYNTCDRIK RGRGGLRSNH  60
   61 STWDPRRNPN LYEELKAPPV PMHGNHYGHA HGNAECHYRH PGMEDEICPY ATFHLLGFRE 120
  121 EMDPTKAMNF QTFPHQNGHA GPVPGHAGTM LPPGHPGHVH SRSGSQSMPR ANRYQRKN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1842-2030]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQGGQSSIYT PAPEYDDPAN CAEEDQYRRY TRVNSQGGSL YSGPGPEYDD PANCAPEEDQ  60
   61 YGSQYGGPYG QPYDHYGSRG SMGRRSIGSA RNPGNGSPEP PPPPPRNHDM SNSSFNDSKE 120
  121 SNEISEAECD RDHGPRGNYG AVKRSPQPKD QRTTEEMRKL IERNETGPKQ LQLQQANGAG 180
  181 FTAYDTMAV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle