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View Structure Prediction Details

Protein: PABPC3
Organism: Homo sapiens
Length: 631 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PABPC3.

Description E-value Query
Range
Subject
Range
gi|109120204 - gi|109120204|ref|XP_001091129.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
0.0 [1..631] [1..637]
gi|73909065 - gi|73909065|gb|AAH45608.1| Poly(A) binding protein, cytoplasmic 3 [Homo sapiens]
0.0 [1..631] [1..631]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
0.0 [1..631] [1..636]
gi|82802761 - gi|82802761|gb|ABB92431.1| PABP3 [Aotus trivirgatus]
0.0 [1..630] [1..629]
gi|26354649 - gi|26354649|dbj|BAC40951.1| unnamed protein product [Mus musculus]
0.0 [1..631] [1..636]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
0.0 [1..631] [1..636]

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Predicted Domain #1
Region A:
Residues: [1-179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG SSNYAYVNFQ  60
   61 HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFVKNLDKSI NNKALYDTVS 120
  121 AFGNILSCNV VCDENGSKGY GFVHFETHEA AERAIKKMNG MLLNGRKVFV GQFKSRKER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
structural molecule activity 2.78501986457503 bayes_pls_golite062009
poly(U) RNA binding 2.49013736906028 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
U2 snRNA binding 1.34078165372485 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 0.597542453741953 bayes_pls_golite062009
hydrolase activity 0.389390547875764 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
single-stranded DNA binding 0.0459458211377304 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [180-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAELGARAKE FPNVYIKNFG EDMDDERLKD LFGKFGPALS VKVMTDESGK SKGFGFVSFE  60
   61 RHEDAQKAVD EMNGKELNGK QIYVGRAQKK VERQTELKRT FEQMKQDRIT RYQVVNLYVK 120
  121 NLDDGIDDER LRKAFSPFGT ITSAKVMMEG GRSKGFGFVC FSSPEEATKA VTEMNGRIVA 180
  181 TKPLYVALAQ RKEERQAYLT NEYM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.0
Match: 1pgzA
Description: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
structural molecule activity 2.78501986457503 bayes_pls_golite062009
poly(U) RNA binding 2.49013736906028 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
U2 snRNA binding 1.34078165372485 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 0.597542453741953 bayes_pls_golite062009
hydrolase activity 0.389390547875764 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
single-stranded DNA binding 0.0459458211377304 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [384-501]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRMASVRAVP NQRAPPSGYF MTAVPQTQNH AAYYPPSQIA RLRPSPRWTA QGARPHPFQN  60
   61 KPSAIRPGAP RVPFSTMRPA SSQVPRVMST QRVANTSTQT VGPRPAAAAA AAATPAVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [502-631]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVPRYKYAAG VRNPQQHRNA QPQVTMQQLA VHVQGQETLT ASRLASAPPQ KQKQMLGERL  60
   61 FPLIQAMHPT LAGKITGMLL EIDNSELLYM LESPESLRSK VDEAVAVLQA HQAKEATQKA 120
  121 VNSATGVPTV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.221849
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.69788763665792 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 5.42285329968544 bayes_pls_golite062009
mRNA binding 5.31297072316889 bayes_pls_golite062009
single-stranded RNA binding 4.51056428709072 bayes_pls_golite062009
nucleic acid binding 3.78909647605682 bayes_pls_golite062009
binding 2.76167454154417 bayes_pls_golite062009
poly(A) RNA binding 2.66269581586161 bayes_pls_golite062009
poly-purine tract binding 2.20136693536924 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.19350242454642 bayes_pls_golite062009
small conjugating protein ligase activity 1.14692713780316 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
ligase activity 0.38737123012383 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009
acid-amino acid ligase activity 0.223805219849164 bayes_pls_golite062009
translation initiation factor binding 0.06484451210501 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle