Protein: | XRN2 |
Organism: | Homo sapiens |
Length: | 950 amino acids |
Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XRN2.
Description | E-value | Query Range |
Subject Range |
|
0.0 | [1..950] | [1..950] |
|
0.0 | [1..950] | [1..950] |
|
0.0 | [1..950] | [1..950] |
|
0.0 | [1..950] | [149..1099] |
|
0.0 | [1..950] | [1..950] |
|
0.0 | [1..950] | [1..951] |
|
0.0 | [1..950] | [65..1015] |
Region A: Residues: [1-497] |
1 11 21 31 41 51 | | | | | | 1 MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH 60 61 PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR 120 121 ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD 180 181 RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG 240 241 LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE 300 301 FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL PSLEIRENAI 360 361 DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE DSIFKKRKDD EDSFRRRQKE 420 421 KRKRMKRDQP AFTPSGILTP HALGSRNSPG SQVASNPRQA AYEMRMQNNS SPSISPNTSF 480 481 TSDGSPSPLG GIKRKAE |
Detection Method: | |
Confidence: | 1.21 |
Match: | 1ul1X |
Description: | Crystal structure of the human FEN1-PCNA complex |
Matching Structure (courtesy of the PDB): |
Term | Confidence | Notes |
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity | 3.71199179880106 | bayes_pls_golite062009 |
exonuclease activity | 3.46607201774246 | bayes_pls_golite062009 |
flap endonuclease activity | 3.35117165021395 | bayes_pls_golite062009 |
endonuclease activity | 2.9231881727799 | bayes_pls_golite062009 |
deoxyribonuclease activity | 2.73550697470983 | bayes_pls_golite062009 |
endodeoxyribonuclease activity | 2.71246687883519 | bayes_pls_golite062009 |
5'-3' exonuclease activity | 2.50129811584994 | bayes_pls_golite062009 |
nuclease activity | 2.49612885073648 | bayes_pls_golite062009 |
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 2.3119851698541 | bayes_pls_golite062009 |
hydrolase activity | 2.24171130786956 | bayes_pls_golite062009 |
ribonuclease activity | 2.17761411301039 | bayes_pls_golite062009 |
hydrolase activity, acting on ester bonds | 2.11221521670814 | bayes_pls_golite062009 |
nucleic acid binding | 2.0553491099036 | bayes_pls_golite062009 |
DNA binding | 1.98330542087379 | bayes_pls_golite062009 |
binding | 1.86375021779651 | bayes_pls_golite062009 |
damaged DNA binding | 1.82833131243547 | bayes_pls_golite062009 |
5'-3' exodeoxyribonuclease activity | 1.59902329953921 | bayes_pls_golite062009 |
structure-specific DNA binding | 1.57088273902548 | bayes_pls_golite062009 |
exodeoxyribonuclease activity | 1.51267299365568 | bayes_pls_golite062009 |
exodeoxyribonuclease activity, producing 5'-phosphomonoesters | 1.49423176639724 | bayes_pls_golite062009 |
single-stranded DNA specific endodeoxyribonuclease activity | 1.47811426277519 | bayes_pls_golite062009 |
double-stranded DNA specific exodeoxyribonuclease activity | 1.46817649825808 | bayes_pls_golite062009 |
catalytic activity | 1.27951740231695 | bayes_pls_golite062009 |
5'-flap endonuclease activity | 1.13738790511505 | bayes_pls_golite062009 |
single-stranded DNA specific exodeoxyribonuclease activity | 1.06918533266108 | bayes_pls_golite062009 |
ribonuclease H activity | 0.943397169110632 | bayes_pls_golite062009 |
double-stranded DNA binding | 0.550147498650064 | bayes_pls_golite062009 |
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity | 0.496731274592508 | bayes_pls_golite062009 |
protein binding | 0.388252010955945 | bayes_pls_golite062009 |
endodeoxyribonuclease activity, producing 5'-phosphomonoesters | 0.330551387282259 | bayes_pls_golite062009 |
3'-5' exonuclease activity | 0.175191448555725 | bayes_pls_golite062009 |
endoribonuclease activity | 0.097472492148219 | bayes_pls_golite062009 |
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0756835782024594 | bayes_pls_golite062009 |
Region A: Residues: [498-650] |
1 11 21 31 41 51 | | | | | | 1 DSDSEPEPED NVRLWEAGWK QRYYKNKFDV DAADEKFRRK VVQSYVEGLC WVLRYYYQGC 60 61 ASWKWYYPFH YAPFASDFEG IADMPSDFEK GTKPFKPLEQ LMGVFPAASG NFLPPSWRKL 120 121 MSDPDSSIID FYPEDFAIDL NGKKYAWQGV ALL |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
Region A: Residues: [651-748] |
1 11 21 31 41 51 | | | | | | 1 PFVDERRLRA ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY QTGSTEPVEV 60 61 PPELCHGIQG KFSLDEEAIL PDQIVCSPVP MLRDLTQN |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
Region A: Residues: [749-807] |
1 11 21 31 41 51 | | | | | | 1 TVVSINFKDP QFAEDYIFKA VMLPGARKPA AVLKPSDWEK SSNGRQWKPQ LGFNRDRRP |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
MCM Score |
SCOP Match |
SCOP Description | ||
View | Download | 0.489 | a.60.1 | SAM/Pointed domain |
View | Download | 0.374 | a.12.1 | Kix domain of CBP (creb binding protein) |
View | Download | 0.442 | d.45.1 | ClpS-like |
View | Download | 0.368 | a.112.1 | Description not found. |
View | Download | 0.361 | a.112.1 | Description not found. |
Region A: Residues: [808-950] |
1 11 21 31 41 51 | | | | | | 1 VHLDQAAFRT LGHVMPRGSG TGIYSNAAPP PVTYQGNLYR PLLRGQAQIP KLMSNMRPQD 60 61 SWRGPPPLFQ QQRFDRGVGA EPLLPWNRML QTQNAAFQPN QYQMLAGPGG YPPRRDDRGG 120 121 RQGYPREGRK YPLPPPSGRY NWN |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.