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View Structure Prediction Details

Protein: XRN2
Organism: Homo sapiens
Length: 950 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XRN2.

Description E-value Query
Range
Subject
Range
gi|114681219 - gi|114681219|ref|XP_514546.2| PREDICTED: hypothetical protein isoform 7 [Pan troglodytes]
0.0 [1..950] [1..950]
gi|73991017 - gi|73991017|ref|XP_534324.2| PREDICTED: similar to 5-3 exoribonuclease 2 isoform 2 [Canis familiaris...
0.0 [1..950] [1..950]
XRN2_PONPY - 5'-3' exoribonuclease 2 - Pongo pygmaeus (Orangutan)
XRN2_PONAB - 5'-3' exoribonuclease 2 OS=Pongo abelii GN=XRN2 PE=2 SV=1
0.0 [1..950] [1..950]
gi|109470962, gi... - gi|109470962|ref|XP_001055882.1| PREDICTED: similar to 5-3 exoribonuclease 2 (Protein Dhm1) [Rattus ...
0.0 [1..950] [149..1099]
gi|5881961 - gi|5881961|gb|AAD55138.1|AF064257_1 Dhm1-like protein [Homo sapiens]
0.0 [1..950] [1..950]
XRN2_MOUSE - 5'-3' exoribonuclease 2 OS=Mus musculus GN=Xrn2 PE=1 SV=1
0.0 [1..950] [1..951]
gi|76632526 - gi|76632526|ref|XP_595586.2| PREDICTED: similar to 5-3 exoribonuclease 2 [Bos taurus]
0.0 [1..950] [65..1015]

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Predicted Domain #1
Region A:
Residues: [1-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH  60
   61 PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR 120
  121 ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD 180
  181 RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG 240
  241 LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE 300
  301 FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL PSLEIRENAI 360
  361 DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE DSIFKKRKDD EDSFRRRQKE 420
  421 KRKRMKRDQP AFTPSGILTP HALGSRNSPG SQVASNPRQA AYEMRMQNNS SPSISPNTSF 480
  481 TSDGSPSPLG GIKRKAE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.21
Match: 1ul1X
Description: Crystal structure of the human FEN1-PCNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 3.71199179880106 bayes_pls_golite062009
exonuclease activity 3.46607201774246 bayes_pls_golite062009
flap endonuclease activity 3.35117165021395 bayes_pls_golite062009
endonuclease activity 2.9231881727799 bayes_pls_golite062009
deoxyribonuclease activity 2.73550697470983 bayes_pls_golite062009
endodeoxyribonuclease activity 2.71246687883519 bayes_pls_golite062009
5'-3' exonuclease activity 2.50129811584994 bayes_pls_golite062009
nuclease activity 2.49612885073648 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.3119851698541 bayes_pls_golite062009
hydrolase activity 2.24171130786956 bayes_pls_golite062009
ribonuclease activity 2.17761411301039 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.11221521670814 bayes_pls_golite062009
nucleic acid binding 2.0553491099036 bayes_pls_golite062009
DNA binding 1.98330542087379 bayes_pls_golite062009
binding 1.86375021779651 bayes_pls_golite062009
damaged DNA binding 1.82833131243547 bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity 1.59902329953921 bayes_pls_golite062009
structure-specific DNA binding 1.57088273902548 bayes_pls_golite062009
exodeoxyribonuclease activity 1.51267299365568 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.49423176639724 bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity 1.47811426277519 bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity 1.46817649825808 bayes_pls_golite062009
catalytic activity 1.27951740231695 bayes_pls_golite062009
5'-flap endonuclease activity 1.13738790511505 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 1.06918533266108 bayes_pls_golite062009
ribonuclease H activity 0.943397169110632 bayes_pls_golite062009
double-stranded DNA binding 0.550147498650064 bayes_pls_golite062009
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity 0.496731274592508 bayes_pls_golite062009
protein binding 0.388252010955945 bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.330551387282259 bayes_pls_golite062009
3'-5' exonuclease activity 0.175191448555725 bayes_pls_golite062009
endoribonuclease activity 0.097472492148219 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0756835782024594 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [498-650]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSDSEPEPED NVRLWEAGWK QRYYKNKFDV DAADEKFRRK VVQSYVEGLC WVLRYYYQGC  60
   61 ASWKWYYPFH YAPFASDFEG IADMPSDFEK GTKPFKPLEQ LMGVFPAASG NFLPPSWRKL 120
  121 MSDPDSSIID FYPEDFAIDL NGKKYAWQGV ALL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [651-748]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFVDERRLRA ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY QTGSTEPVEV  60
   61 PPELCHGIQG KFSLDEEAIL PDQIVCSPVP MLRDLTQN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [749-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVVSINFKDP QFAEDYIFKA VMLPGARKPA AVLKPSDWEK SSNGRQWKPQ LGFNRDRRP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.489 a.60.1 SAM/Pointed domain
View Download 0.374 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.442 d.45.1 ClpS-like
View Download 0.368 a.112.1 Description not found.
View Download 0.361 a.112.1 Description not found.

Predicted Domain #5
Region A:
Residues: [808-950]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHLDQAAFRT LGHVMPRGSG TGIYSNAAPP PVTYQGNLYR PLLRGQAQIP KLMSNMRPQD  60
   61 SWRGPPPLFQ QQRFDRGVGA EPLLPWNRML QTQNAAFQPN QYQMLAGPGG YPPRRDDRGG 120
  121 RQGYPREGRK YPLPPPSGRY NWN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle