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Protein Overview: XRN2

General Information:
Name(s) found: XRN2 [HGNC (HUGO)]
Description(s) found:
Found 29 descriptions.
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  • 5'-3' exoribonuclease 2 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 950 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH  60
   61 PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR 120
  121 ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD 180
  181 RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG 240
  241 LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE 300
  301 FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL PSLEIRENAI 360
  361 DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE DSIFKKRKDD EDSFRRRQKE 420
  421 KRKRMKRDQP AFTPSGILTP HALGSRNSPG SQVASNPRQA AYEMRMQNNS SPSISPNTSF 480
  481 TSDGSPSPLG GIKRKAEDSD SEPEPEDNVR LWEAGWKQRY YKNKFDVDAA DEKFRRKVVQ 540
  541 SYVEGLCWVL RYYYQGCASW KWYYPFHYAP FASDFEGIAD MPSDFEKGTK PFKPLEQLMG 600
  601 VFPAASGNFL PPSWRKLMSD PDSSIIDFYP EDFAIDLNGK KYAWQGVALL PFVDERRLRA 660
  661 ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY QTGSTEPVEV PPELCHGIQG 720
  721 KFSLDEEAIL PDQIVCSPVP MLRDLTQNTV VSINFKDPQF AEDYIFKAVM LPGARKPAAV 780
  781 LKPSDWEKSS NGRQWKPQLG FNRDRRPVHL DQAAFRTLGH VMPRGSGTGI YSNAAPPPVT 840
  841 YQGNLYRPLL RGQAQIPKLM SNMRPQDSWR GPPPLFQQQR FDRGVGAEPL LPWNRMLQTQ 900
  901 NAAFQPNQYQ MLAGPGGYPP RRDDRGGRQG YPREGRKYPL PPPSGRYNWN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..497] FFAS03 1.21 Crystal structure of the human FEN1-PCNA complex
    2 View Details [498..650] MSA 2.086954 View MSA. No confident structure predictions are available.
    3 View Details [651..748] MSA 2.080985 View MSA. No confident structure predictions are available.
    4 View Details [749..807] deduced N/A No confident structure predictions are available.
    5 View Details [808..950] MSA 3.032997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  3.71199179880106 bayes_pls_golite062009
  • exonuclease activity
    		•  3.46607201774246 bayes_pls_golite062009
  • flap endonuclease activity
    		•  3.35117165021395 bayes_pls_golite062009
  • endonuclease activity
    		•  2.9231881727799 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.73550697470983 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  2.71246687883519 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  2.50129811584994 bayes_pls_golite062009
  • nuclease activity
    		•  2.49612885073648 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.3119851698541 bayes_pls_golite062009
  • hydrolase activity
    		•  2.24171130786956 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.17761411301039 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.11221521670814 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.0553491099036 bayes_pls_golite062009
  • DNA binding
    		•  1.98330542087379 bayes_pls_golite062009
  • binding
    		•  1.86375021779651 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.82833131243547 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  1.59902329953921 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.57088273902548 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  1.51267299365568 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.49423176639724 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  1.47811426277519 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  1.46817649825808 bayes_pls_golite062009
  • catalytic activity
    		•  1.27951740231695 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.13738790511505 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  1.06918533266108 bayes_pls_golite062009
  • ribonuclease H activity
    		•  0.943397169110632 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.550147498650064 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  0.496731274592508 bayes_pls_golite062009
  • protein binding
    		•  0.388252010955945 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.330551387282259 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.175191448555725 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.097472492148219 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.0756835782024594 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle