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View Structure Prediction Details

Protein: PEX12
Organism: Homo sapiens
Length: 359 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX12.

Description E-value Query
Range
Subject
Range
gi|114668062, gi... - gi|114668064|ref|XP_523610.2| PREDICTED: peroxisomal biogenesis factor 12 isoform 2 [Pan troglodytes...
2.0E-89 [1..359] [1..359]
PEX12_MOUSE - Peroxisome assembly protein 12 OS=Mus musculus GN=Pex12 PE=1 SV=1
4.0E-87 [1..359] [1..359]
gi|57091801 - gi|57091801|ref|XP_548259.1| PREDICTED: similar to Peroxisome assembly protein 12 (Peroxin-12) (Pero...
9.0E-87 [1..359] [1..359]
PEX12_BOVIN - Peroxisome assembly protein 12 OS=Bos taurus GN=PEX12 PE=2 SV=1
3.0E-86 [1..359] [1..359]
PEX12_CRILO - Peroxisome assembly protein 12 OS=Cricetulus longicaudatus GN=PEX12 PE=2 SV=1
tr|G3I8C0|G3I8C0... - Peroxisome assembly protein 12 OS=Cricetulus griseus GN=I79_019783 PE=3 SV=1
2.0E-85 [1..359] [1..359]
PEX12_RAT - Peroxisome assembly protein 12 OS=Rattus norvegicus GN=Pex12 PE=2 SV=1
2.0E-84 [1..359] [1..359]
gi|37362262 - gi|37362262|gb|AAQ91259.1| peroxisomal biogenesis factor 12 [Danio rerio]
7.0E-79 [1..358] [1..349]
prx-12 - Zinc finger, C3HC4 type (RING finger) status:Partially_confirmed UniProt:Q19189 protein_id:CAA92113....
1.0E-67 [2..355] [7..358]
gi|187025834, gi... - gi|39594778|emb|CAE70646.1| Hypothetical protein CBG17349 [Caenorhabditis briggsae], gi|187025834|em...
gi|157768368 - gi|157768368|ref|XP_001676005.1| Hypothetical protein CBG17349 [Caenorhabditis briggsae AF16]
9.0E-66 [4..355] [6..341]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEHGAHFTA ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPT HYGFLWRWFD  60
   61 EIFTLLDLLL QQHYLSRTSA SFSENFYGLK RIVMGDTHKS QRLASAGLPK QQLWKSIMFL 120
  121 VLLPYLKVKL EKLVSSLR

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 18.481486
Match: PF04757.5
Description: No description for PF04757.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.928 0.008 peroxisomal membrane a.72.1 Functional domain of the splicing factor Prp18

Predicted Domain #2
Region A:
Residues: [139-359]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEDEYSIHPP SSRWKRFYRA FLAAYPFVNM AWEGWFLVQQ LRYILGKAQH HSPLLRLAGV  60
   61 QLGRLTVQDI QALEHKPAKA SMMQQPARSV SEKINSALKK AVGGVALSLS TGLSVGVFFL 120
  121 QFLDWWYSSE NQETIKSLTA LPTPPPPVHL DYNSDSPLLP KMKTVCPLCR KTRVNDTVLA 180
  181 TSGYVFCYRC VFHYVRSHQA CPITGYPTEV QHLIKLYSPE N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.154902
Match: 1fbvA
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
signal transducer activity 2.59589726924784 bayes_pls_golite062009
molecular transducer activity 2.59589726924784 bayes_pls_golite062009
binding 2.49943137715788 bayes_pls_golite062009
protein binding 2.04603930248857 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
calcium ion binding 1.03474411638676 bayes_pls_golite062009
molecular adaptor activity 1.01125482062944 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.80276046490236 bayes_pls_golite062009
receptor binding 0.79540672491346 bayes_pls_golite062009
cytoskeletal protein binding 0.75057755360417 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.45412801027969 bayes_pls_golite062009
protein binding, bridging 0.28270375006511 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
ion transmembrane transporter activity 0.193201281459889 bayes_pls_golite062009
cation transmembrane transporter activity 0.0305250212662123 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle