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View Structure Prediction Details

Protein: FOLH1
Organism: Homo sapiens
Length: 750 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOLH1.

Description E-value Query
Range
Subject
Range
gi|76674964 - gi|76674964|ref|XP_582226.2| PREDICTED: similar to folate hydrolase 1 isoform 1 [Bos taurus]
0.0 [1..750] [119..868]
gi|114637611 - gi|114637611|ref|XP_001170546.1| PREDICTED: folate hydrolase 1 isoform 3 [Pan troglodytes]
0.0 [1..750] [1..750]
FOLH1_PIG - Glutamate carboxypeptidase 2 OS=Sus scrofa GN=FOLH1 PE=1 SV=1
0.0 [1..750] [1..751]
FOLH1_RAT - Glutamate carboxypeptidase 2 OS=Rattus norvegicus GN=Folh1 PE=1 SV=1
0.0 [1..749] [1..751]
gi|2897946 - gi|2897946|gb|AAC83972.1| prostate-specific membrane antigen [Homo sapiens]
0.0 [1..750] [1..750]
FOLH1_MOUSE - Glutamate carboxypeptidase 2 OS=Mus musculus GN=Folh1 PE=1 SV=2
0.0 [1..750] [1..752]
gi|109108238 - gi|109108238|ref|XP_001096141.1| PREDICTED: similar to folate hydrolase 1 isoform 1 [Macaca mulatta]
0.0 [2..750] [52..800]

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Predicted Domain #1
Region A:
Residues: [1-750]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKA  60
   61 FLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYP 120
  121 NKTHPNYISI INEDGNEIFN TSLFEPPPPG YENVSDIVPP FSAFSPQGMP EGDLVYVNYA 180
  181 RTEDFFKLER DMKINCSGKI VIARYGKVFR GNKVKNAQLA GAKGVILYSD PADYFAPGVK 240
  241 SYPDGWNLPG GGVQRGNILN LNGAGDPLTP GYPANEYAYR RGIAEAVGLP SIPVHPIGYY 300
  301 DAQKLLEKMG GSAPPDSSWR GSLKVPYNVG PGFTGNFSTQ KVKMHIHSTN EVTRIYNVIG 360
  361 TLRGAVEPDR YVILGGHRDS WVFGGIDPQS GAAVVHEIVR SFGTLKKEGW RPRRTILFAS 420
  421 WDAEEFGLLG STEWAEENSR LLQERGVAYI NADSSIEGNY TLRVDCTPLM YSLVHNLTKE 480
  481 LKSPDEGFEG KSLYESWTKK SPSPEFSGMP RISKLGSGND FEVFFQRLGI ASGRARYTKN 540
  541 WETNKFSGYP LYHSVYETYE LVEKFYDPMF KYHLTVAQVR GGMVFELANS IVLPFDCRDY 600
  601 AVVLRKYADK IYSISMKHPQ EMKTYSVSFD SLFSAVKNFT EIASKFSERL QDFDKSNPIV 660
  661 LRMMNDQLMF LERAFIDPLG LPDRPFYRHV IYAPSSHNKY AGESFPGIYD ALFDIESKVD 720
  721 PSKAWGEVKR QIYVAAFTVQ AAAETLSEVA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 2ootA
Description: No description for 2ootA was found.

Predicted functions:

Term Confidence Notes
peptidase activity 4.786910294594 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40766568731738 bayes_pls_golite062009
transferrin receptor activity 4.23222910697724 bayes_pls_golite062009
metal ion transmembrane transporter activity 3.22550147993876 bayes_pls_golite062009
hydrolase activity 2.98013991489506 bayes_pls_golite062009
ion transmembrane transporter activity 2.89997705780823 bayes_pls_golite062009
cation transmembrane transporter activity 2.88322998065547 bayes_pls_golite062009
exopeptidase activity 2.85109457647548 bayes_pls_golite062009
metallopeptidase activity 2.76103081380105 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.68490358267624 bayes_pls_golite062009
transmembrane receptor activity 2.66431152897721 bayes_pls_golite062009
receptor activity 2.50668975998057 bayes_pls_golite062009
signal transducer activity 2.43554678928141 bayes_pls_golite062009
molecular transducer activity 2.43554678928141 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 2.20995944464635 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.13164513953563 bayes_pls_golite062009
metalloexopeptidase activity 1.76058821499096 bayes_pls_golite062009
transporter activity 1.41427351827978 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
transmembrane transporter activity 1.21006084747883 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 1.20973073749196 bayes_pls_golite062009
iron ion transmembrane transporter activity 1.15627568837889 bayes_pls_golite062009
metallocarboxypeptidase activity 1.15035221474504 bayes_pls_golite062009
binding 1.13031326446259 bayes_pls_golite062009
substrate-specific transporter activity 0.982528171716301 bayes_pls_golite062009
nucleic acid binding 0.928708750561725 bayes_pls_golite062009
endopeptidase activity 0.910234727191613 bayes_pls_golite062009
carboxypeptidase activity 0.891655769761122 bayes_pls_golite062009
transcription regulator activity 0.750920789301107 bayes_pls_golite062009
DNA binding 0.629467984227905 bayes_pls_golite062009
serine hydrolase activity 0.596149133958797 bayes_pls_golite062009
serine-type peptidase activity 0.578572340123331 bayes_pls_golite062009
transition metal ion binding 0.140027513499495 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.103908874877312 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle